SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		5 / 12 VAL A  77
LEU A  85
GLY A 181
PRO A 182
MET A 113
 None
 1.43A 1fdsA-1v6zA:
3.7		 1fdsA-1v6zA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		5 / 11 GLY A 181
GLY A 185
LEU A 209
ALA A 211
ALA A 214
 None
 0.59A 1x7pA-1v6zA:
13.6
1x7pB-1v6zA:
13.6		 1x7pA-1v6zA:
26.64
1x7pB-1v6zA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		4 / 5 PRO A 102
VAL A  77
VAL A  88
ILE A 100
 None
 0.93A 1z2bC-1v6zA:
undetectable		 1z2bC-1v6zA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		4 / 5 LEU A 103
PRO A 150
VAL A 149
ILE A 144
 None
 0.86A 2aoiB-1v6zA:
undetectable		 2aoiB-1v6zA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		6 / 12 VAL A 180
GLY A 181
GLY A 185
LEU A 204
LEU A 209
ALA A 214
 None
 0.38A 2egvA-1v6zA:
23.8		 2egvA-1v6zA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		6 / 12 VAL A 180
GLY A 181
GLY A 185
LEU A 204
LEU A 209
ALA A 214
 None
 0.46A 2egvB-1v6zA:
18.7		 2egvB-1v6zA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		3 / 3 LEU A  15
PRO A  16
ARG A   5
 None
 0.66A 2qd4B-1v6zA:
2.7		 2qd4B-1v6zA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		3 / 3 LEU A  15
PRO A  16
ARG A   5
 None
 0.55A 2qd5A-1v6zA:
undetectable		 2qd5A-1v6zA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		5 / 10 VAL A 180
GLY A 181
LEU A 204
LEU A 209
ALA A 214
 None
 0.63A 2v3kA-1v6zA:
7.7		 2v3kA-1v6zA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		7 / 9 ALA A 158
VAL A 160
GLY A 185
LEU A 204
ILE A 208
LEU A 209
ALA A 214
 None
 0.74A 2z0yA-1v6zA:
32.5		 2z0yA-1v6zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		8 / 9 ALA A 158
VAL A 180
GLY A 181
GLY A 185
LEU A 204
ILE A 208
LEU A 209
ALA A 214
 None
 0.59A 2z0yA-1v6zA:
32.5		 2z0yA-1v6zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		9 / 9 ALA A 158
VAL A 160
VAL A 180
GLY A 181
GLY A 185
LEU A 204
ILE A 208
LEU A 209
ALA A 214
 None
 0.63A 2z0yB-1v6zA:
30.8		 2z0yB-1v6zA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		3 / 3 LEU A  15
PRO A  16
ARG A   5
 None
 0.68A 4klrB-1v6zA:
3.0		 4klrB-1v6zA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		4 / 6 ARG A  63
PRO A  65
ARG A   5
THR A  36
 None
 1.04A 5ih0A-1v6zA:
undetectable		 5ih0A-1v6zA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		5 / 11 LEU A  75
PRO A 102
ARG A  90
THR A  93
ALA A  92
 None
 1.03A 5o96A-1v6zA:
21.1
5o96B-1v6zA:
17.8		 5o96A-1v6zA:
34.00
5o96B-1v6zA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		5 / 9 GLY A 181
GLY A 185
LEU A 204
LEU A 209
ALA A 214
 None
 0.40A 5o96A-1v6zA:
21.1
5o96B-1v6zA:
17.8		 5o96A-1v6zA:
34.00
5o96B-1v6zA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		5 / 7 GLY A 181
GLY A 185
SER A 203
LEU A 209
ALA A 214
 None
 0.73A 5o96C-1v6zA:
21.2		 5o96C-1v6zA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		6 / 11 GLY A 181
GLU A 183
GLY A 185
SER A 203
LEU A 204
ALA A 214
 None
 0.84A 5o96G-1v6zA:
21.5		 5o96G-1v6zA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		6 / 11 GLY A 181
GLY A 185
SER A 203
LEU A 204
GLU A 212
ALA A 214
 None
 0.79A 5o96G-1v6zA:
21.5		 5o96G-1v6zA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		5 / 10 GLY A 181
GLY A 185
LEU A 204
LEU A 209
ALA A 214
 None
 0.45A 5o96G-1v6zA:
21.5
5o96H-1v6zA:
21.9		 5o96G-1v6zA:
34.00
5o96H-1v6zA:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		5 / 12 GLY A  96
VAL A 136
LEU A 219
VAL A  73
LEU A 178
 None
 1.16A 5ubbA-1v6zA:
undetectable		 5ubbA-1v6zA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1v6z HYPOTHETICAL PROTEIN
TTHA0657
(Thermus
thermophilus) 		5 / 10 VAL A 180
GLY A 181
GLY A 185
LEU A 209
ALA A 214
 None
 0.50A 5vm8B-1v6zA:
18.5		 5vm8B-1v6zA:
33.85