SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1v77 HYPOTHETICAL PROTEIN
PH1877
(Pyrococcus
horikoshii) 		5 / 8 ASP A 180
ILE A 199
ILE A 182
GLY A 185
ILE A 188
 None
 1.17A 1sh9A-1v77A:
undetectable		 1sh9A-1v77A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1v77 HYPOTHETICAL PROTEIN
PH1877
(Pyrococcus
horikoshii) 		5 / 12 ALA A 126
TYR A 202
GLY A 128
LEU A 127
PHE A 129
 None
 1.30A 1vpoH-1v77A:
undetectable
1vpoL-1v77A:
undetectable		 1vpoH-1v77A:
21.58
1vpoL-1v77A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1v77 HYPOTHETICAL PROTEIN
PH1877
(Pyrococcus
horikoshii) 		4 / 8 LEU A 145
ILE A 188
GLY A 128
ILE A 101
 None
 0.71A 2o4nB-1v77A:
undetectable		 2o4nB-1v77A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1v77 HYPOTHETICAL PROTEIN
PH1877
(Pyrococcus
horikoshii) 		4 / 4 LEU A 134
LEU A 181
MET A 149
MET A 190
 None
 1.30A 2oaxB-1v77A:
0.0		 2oaxB-1v77A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 1v77 HYPOTHETICAL PROTEIN
PH1877
(Pyrococcus
horikoshii) 		3 / 3 PRO A 103
PHE A 129
ALA A 152
 None
 0.54A 3itaD-1v77A:
0.0		 3itaD-1v77A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 1v77 HYPOTHETICAL PROTEIN
PH1877
(Pyrococcus
horikoshii) 		3 / 3 PRO A 203
ILE A  34
SER A 198
 None
 0.64A 5fsaA-1v77A:
undetectable		 5fsaA-1v77A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 1v77 HYPOTHETICAL PROTEIN
PH1877
(Pyrococcus
horikoshii) 		4 / 8 ILE A 101
MET A 190
LEU A 181
ILE A 199
 None
 0.94A 5ieoA-1v77A:
0.0		 5ieoA-1v77A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 1v77 HYPOTHETICAL PROTEIN
PH1877
(Pyrococcus
horikoshii) 		4 / 5 LEU A  78
VAL A  31
GLU A  29
LEU A 207
 None
 1.06A 5xooB-1v77A:
undetectable		 5xooB-1v77A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 1v77 HYPOTHETICAL PROTEIN
PH1877
(Pyrococcus
horikoshii) 		3 / 3 ARG A 107
PHE A 148
GLY A 111
 None
 0.80A 6fgdA-1v77A:
undetectable		 6fgdA-1v77A:
21.48