SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 1v7l 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 6 ALA A  71
LEU A  74
ILE A  19
SER A  69
 None
 1.05A 1sbrA-1v7lA:
undetectable
1sbrB-1v7lA:
undetectable		 1sbrA-1v7lA:
20.64
1sbrB-1v7lA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 1v7l 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		4 / 8 GLY A  58
GLU A  85
ALA A  84
ASN A  60
 None
 0.85A 2dtjA-1v7lA:
undetectable
2dtjB-1v7lA:
undetectable		 2dtjA-1v7lA:
26.04
2dtjB-1v7lA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 1v7l 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 12 GLY A  81
LEU A 103
ILE A  96
VAL A 145
LEU A 142
 None
 1.06A 4fr0A-1v7lA:
undetectable		 4fr0A-1v7lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1v7l 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT
(Pyrococcus
horikoshii) 		5 / 12 ILE A 144
GLU A 147
GLY A 148
ASN A  94
LEU A 151
 None
 1.30A 5fhzD-1v7lA:
undetectable		 5fhzD-1v7lA:
16.34