SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_D_VDYD1001_2 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	1v7n	THROMBOPOIETIN (Homo sapiens)	3 / 3	LEU V 64 VAL V 67 LEU V 71	None	0.49A	1mz9B-1v7nV: undetectable	1mz9B-1v7nV: 13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NV4_B_SAMB202_0 (UPF0066 PROTEIN AF_0241)	1v7n	THROMBOPOIETIN (Homo sapiens)	5 / 12	GLN V 61 ALA V 60 GLY V 102 LEU V 99 LEU V 108	None	1.35A	2nv4B-1v7nV: 0.0	2nv4B-1v7nV: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PD9_A_ADNA501_1 (NUPC FAMILY PROTEIN)	1v7n	THROMBOPOIETIN (Homo sapiens)	5 / 12	GLY V 95 GLN V 96 VAL V 74 LEU V 70 SER V 19	None	1.22A	4pd9A-1v7nV: undetectable	4pd9A-1v7nV: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ND7_B_TA1B601_1 (TUBULIN BETA-2B CHAIN)	1v7n	THROMBOPOIETIN (Homo sapiens)	5 / 12	LEU V 135 LEU V 100 ALA V 103 SER V 106 ARG V 17	None	1.11A	5nd7B-1v7nV: undetectable	5nd7B-1v7nV: 16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_P_CHDP307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1v7n	THROMBOPOIETIN (Homo sapiens)	4 / 5	ARG V 25 LEU V 22 GLN V 132 PHE V 131	None	1.08A	6nmpP-1v7nV: 1.1 6nmpW-1v7nV: undetectable	6nmpP-1v7nV: 20.63 6nmpW-1v7nV: 20.29

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MZ9_D_VDYD1001_2","CARTILAGE OLIGOMERIC MATRIX PROTEIN;CARTILAGE OLIGOMERIC MATRIX PROTEIN","1v7n","THROMBOPOIETIN","Homo sapiens",3,"LEU V  64;VAL V  67;LEU V  71","None","0.49A","1mz9B-1v7nV:undetectable","1mz9B-1v7nV:13.29"],["2NV4_B_SAMB202_0","UPF0066 PROTEIN AF_0241","1v7n","THROMBOPOIETIN","Homo sapiens",5,"GLN V  61;ALA V  60;GLY V 102;LEU V  99;LEU V 108","None","1.35A","2nv4B-1v7nV:0.0","2nv4B-1v7nV:18.68"],["4PD9_A_ADNA501_1","NUPC FAMILY PROTEIN","1v7n","THROMBOPOIETIN","Homo sapiens",5,"GLY V  95;GLN V  96;VAL V  74;LEU V  70;SER V  19","None","1.22A","4pd9A-1v7nV:undetectable","4pd9A-1v7nV:18.16"],["5ND7_B_TA1B601_1","TUBULIN BETA-2B CHAIN","1v7n","THROMBOPOIETIN","Homo sapiens",5,"LEU V 135;LEU V 100;ALA V 103;SER V 106;ARG V  17","None","1.11A","5nd7B-1v7nV:undetectable","5nd7B-1v7nV:16.31"],["6NMP_P_CHDP307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1v7n","THROMBOPOIETIN","Homo sapiens",4,"ARG V  25;LEU V  22;GLN V 132;PHE V 131","None","1.08A","6nmpP-1v7nV:1.1;6nmpW-1v7nV:undetectable","6nmpP-1v7nV:20.63;6nmpW-1v7nV:20.29"]]