SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v84'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 TRP A 217
ALA A 229
VAL A 219
 None
 0.94A 1c4dA-1v84A:
undetectable
1c4dB-1v84A:
undetectable		 1c4dA-1v84A:
12.22
1c4dB-1v84A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ALA A 229
VAL A 219
TRP A 217
 None
 0.95A 1c4dC-1v84A:
undetectable
1c4dD-1v84A:
undetectable		 1c4dC-1v84A:
12.22
1c4dD-1v84A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 ASP A 197
ASN A 198
ASP A 195
TYR A  93
 MN  A 501 ( 2.0A)
MN  A 501 ( 4.6A)
UDP  A 503 (-3.5A)
UDP  A 503 (-3.7A)
 1.39A 1hpkA-1v84A:
undetectable		 1hpkA-1v84A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 HIS A 311
ALA A 256
ALA A 194
THR A  90
 UDP  A 503 (-4.2A)
None
None
None
 0.93A 2xfhA-1v84A:
undetectable		 2xfhA-1v84A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 VAL A 112
THR A 137
THR A  85
ARG A 209
 None
 1.28A 3bjwG-1v84A:
0.0		 3bjwG-1v84A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 VAL A 112
THR A 137
THR A  85
ARG A 209
 None
 1.12A 3bjwD-1v84A:
undetectable		 3bjwD-1v84A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 7 TYR A 272
LEU A 287
ASN A 171
THR A 180
 None
 0.93A 3lm8B-1v84A:
undetectable
3lm8D-1v84A:
2.5		 3lm8B-1v84A:
19.78
3lm8D-1v84A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 7 MET A 255
ARG A 178
VAL A 214
MET A 208
 None
 1.34A 4f4dA-1v84A:
0.0		 4f4dA-1v84A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 11 LYS A  99
LEU A 102
LEU A 133
ARG A 135
LEU A 134
 None
 1.13A 4wg0G-1v84A:
undetectable
4wg0H-1v84A:
undetectable
4wg0I-1v84A:
undetectable		 4wg0G-1v84A:
5.22
4wg0H-1v84A:
5.22
4wg0I-1v84A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 11 LEU A 133
ARG A 135
LEU A 134
LYS A  99
LEU A 102
 None
 1.14A 4wg0J-1v84A:
undetectable
4wg0K-1v84A:
undetectable
4wg0L-1v84A:
undetectable		 4wg0J-1v84A:
5.22
4wg0K-1v84A:
5.22
4wg0L-1v84A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 11 LYS A  99
LEU A 102
LEU A 133
ARG A 135
LEU A 134
 None
 1.19A 4wg0I-1v84A:
undetectable
4wg0J-1v84A:
undetectable
4wg0K-1v84A:
undetectable		 4wg0I-1v84A:
5.22
4wg0J-1v84A:
5.22
4wg0K-1v84A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 7 LEU A 133
ARG A 135
LEU A 134
LYS A  99
LEU A 102
 None
 1.15A 4wg0L-1v84A:
undetectable
4wg0M-1v84A:
undetectable		 4wg0L-1v84A:
5.22
4wg0M-1v84A:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 VAL A 214
LEU A 297
VAL A 216
 None
 0.57A 4wq4A-1v84A:
undetectable		 4wq4A-1v84A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 ARG A 170
ASP A 195
HIS A 311
ARG A 313
 UDP  A 503 (-4.4A)
UDP  A 503 (-3.5A)
UDP  A 503 (-4.2A)
UDP  A 503 (-3.5A)
 1.01A 5a06A-1v84A:
undetectable		 5a06A-1v84A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 ILE A 253
VAL A 238
VAL A 216
TRP A 241
 None
 0.69A 5jwaH-1v84A:
undetectable		 5jwaH-1v84A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1v84 GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ASP A 197
ASN A 198
ASP A 254
 MN  A 501 ( 2.0A)
MN  A 501 ( 4.6A)
GAL  A 505 (-3.7A)
 0.83A 5vopA-1v84A:
undetectable		 5vopA-1v84A:
23.64