SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		3 / 3 ASP A 347
ARG A 388
ILE A  80
 None
 0.79A 1a4gB-1v8bA:
undetectable		 1a4gB-1v8bA:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 HIS A  54
ASP A 134
LYS A 230
ASP A 234
LEU A 392
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
 1.27A 1d4fA-1v8bA:
54.1		 1d4fA-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
GLU A  58
ASP A 134
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.31A 1d4fA-1v8bA:
54.1		 1d4fA-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 HIS A  54
ASP A 134
LYS A 230
ASP A 234
LEU A 392
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
 1.36A 1d4fB-1v8bA:
54.1		 1d4fB-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
GLU A  58
ASP A 134
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.35A 1d4fB-1v8bA:
54.1		 1d4fB-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 THR A  56
GLU A 200
THR A 201
HIS A 398
 ADN  A 502 (-3.0A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
ADN  A 502 ( 3.5A)
 0.60A 1d4fB-1v8bA:
54.1		 1d4fB-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 ASP A 134
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.33A 1d4fC-1v8bA:
54.1		 1d4fC-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
GLU A  58
ASP A 134
LYS A 230
ASP A 234
LEU A 389
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.31A 1d4fC-1v8bA:
54.1		 1d4fC-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 HIS A  54
ASP A 134
LYS A 230
ASP A 234
LEU A 392
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
 1.37A 1d4fD-1v8bA:
54.0		 1d4fD-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
GLU A  58
ASP A 134
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.36A 1d4fD-1v8bA:
54.0		 1d4fD-1v8bA:
52.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 GLY A 271
ALA A 273
SER A 275
GLY A 278
LEU A 279
 None
 1.06A 1fe2A-1v8bA:
0.0		 1fe2A-1v8bA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 4 GLY A 136
LEU A 140
GLY A 204
ARG A 207
 None
 1.31A 1j7kA-1v8bA:
undetectable		 1j7kA-1v8bA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 4 HIS A 398
VAL A 402
THR A  56
LEU A  61
 ADN  A 502 ( 3.5A)
None
ADN  A 502 (-3.0A)
None
 1.35A 1oq5A-1v8bA:
undetectable		 1oq5A-1v8bA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 ALA A 281
LEU A 390
MET A 276
GLY A 278
LEU A 243
 None
 1.18A 1qabF-1v8bA:
undetectable		 1qabF-1v8bA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 THR A 251
ILE A 373
LEU A 355
VAL A 352
LEU A 384
 None
 1.14A 1r30A-1v8bA:
undetectable		 1r30A-1v8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 THR A 251
ILE A 373
LEU A 355
VAL A 352
LEU A 384
 None
 1.14A 1r30B-1v8bA:
undetectable		 1r30B-1v8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 7 PHE A 172
GLU A 115
LEU A 141
THR A 174
LYS A 177
 None
 1.43A 1rmtB-1v8bA:
3.2		 1rmtB-1v8bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 8 PHE A 412
ASN A 409
SER A 404
ALA A 227
 None
 1.16A 1rqpC-1v8bA:
3.5		 1rqpC-1v8bA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 8 PHE A 412
ASN A 409
SER A 404
ALA A 227
 None
 1.18A 1rqpA-1v8bA:
3.4		 1rqpA-1v8bA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 LEU A 415
ILE A 222
LEU A 433
PRO A 434
THR A  65
 None
 1.13A 1rx8A-1v8bA:
undetectable		 1rx8A-1v8bA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 6 LEU A 415
PHE A 412
ALA A 413
LEU A  44
 None
 0.92A 1ukbA-1v8bA:
5.7		 1ukbA-1v8bA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 PHE A 405
ALA A 442
LEU A 446
ARG A  33
PHE A 401
 None
 0.93A 1xdkF-1v8bA:
undetectable		 1xdkF-1v8bA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		8 / 12 LEU A  53
GLU A  58
ASP A 234
LEU A 389
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.99A 1xwfA-1v8bA:
50.0		 1xwfA-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 LEU A  53
HIS A  54
GLU A  58
ASP A 134
ASP A 234
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.95A 1xwfA-1v8bA:
50.0		 1xwfA-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 LEU A  53
HIS A  54
THR A  56
GLU A  58
ASP A 134
ASP A 234
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.80A 1xwfA-1v8bA:
50.0		 1xwfA-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		8 / 12 LEU A  53
THR A  56
GLU A  58
ASP A 234
LEU A 389
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.97A 1xwfA-1v8bA:
50.0		 1xwfA-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		8 / 12 LEU A  53
GLU A  58
ASP A 234
LEU A 389
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 1.03A 1xwfB-1v8bA:
50.1		 1xwfB-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 LEU A  53
HIS A  54
GLU A  58
ASP A 134
ASP A 234
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.99A 1xwfB-1v8bA:
50.1		 1xwfB-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 LEU A  53
HIS A  54
THR A  56
GLU A  58
ASP A 134
ASP A 234
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.81A 1xwfB-1v8bA:
50.1		 1xwfB-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		8 / 12 LEU A  53
THR A  56
GLU A  58
ASP A 234
LEU A 389
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 1.00A 1xwfB-1v8bA:
50.1		 1xwfB-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 GLU A  58
ASP A 234
LEU A 389
LEU A 392
GLY A 397
MET A 403
PHE A 407
 ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.93A 1xwfC-1v8bA:
49.9		 1xwfC-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 LEU A  53
HIS A  54
GLU A  58
ASP A 134
ASP A 234
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.98A 1xwfC-1v8bA:
49.9		 1xwfC-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 LEU A  53
HIS A  54
THR A  56
GLU A  58
ASP A 134
ASP A 234
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.81A 1xwfC-1v8bA:
49.9		 1xwfC-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 THR A  56
GLU A  58
ASP A 234
LEU A 389
GLY A 397
MET A 403
PHE A 407
 ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.95A 1xwfC-1v8bA:
49.9		 1xwfC-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 GLU A  58
ASP A 234
LEU A 389
LEU A 392
GLY A 397
MET A 403
PHE A 407
 ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.95A 1xwfD-1v8bA:
49.9		 1xwfD-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 LEU A  53
HIS A  54
GLU A  58
ASP A 134
ASP A 234
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 1.01A 1xwfD-1v8bA:
49.9		 1xwfD-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 LEU A  53
HIS A  54
THR A  56
GLU A  58
ASP A 134
ASP A 234
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.83A 1xwfD-1v8bA:
49.9		 1xwfD-1v8bA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 THR A  56
GLU A  58
ASP A 234
LEU A 389
GLY A 397
MET A 403
PHE A 407
 ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.96A 1xwfD-1v8bA:
49.9		 1xwfD-1v8bA:
52.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 ILE A 350
LEU A 375
LEU A 332
GLU A 354
LEU A 328
 None
 1.15A 2bxfA-1v8bA:
undetectable		 2bxfA-1v8bA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 8 LEU A 243
GLY A 387
ILE A 350
LEU A 247
 None
 0.72A 2o4nB-1v8bA:
undetectable		 2o4nB-1v8bA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 8 PHE A 412
ASN A 409
SER A 404
ALA A 227
 None
 1.16A 2v7uA-1v8bA:
2.3		 2v7uA-1v8bA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.53A 2zj0A-1v8bA:
57.9		 2zj0A-1v8bA:
54.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.28A 2zj0B-1v8bA:
58.0		 2zj0B-1v8bA:
54.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.66A 2zj0B-1v8bA:
58.0		 2zj0B-1v8bA:
54.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.30A 2zj0C-1v8bA:
58.1		 2zj0C-1v8bA:
54.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.60A 2zj0C-1v8bA:
58.1		 2zj0C-1v8bA:
54.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.55A 2zj0D-1v8bA:
58.0		 2zj0D-1v8bA:
54.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 11 VAL A 383
GLY A 387
THR A 318
ILE A 326
LEU A 331
 None
 1.41A 3bf1A-1v8bA:
undetectable
3bf1B-1v8bA:
2.2		 3bf1A-1v8bA:
19.96
3bf1B-1v8bA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.56A 3ce6A-1v8bA:
59.4		 3ce6A-1v8bA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.30A 3ce6B-1v8bA:
58.1		 3ce6B-1v8bA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.67A 3ce6B-1v8bA:
58.1		 3ce6B-1v8bA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.55A 3ce6C-1v8bA:
58.2		 3ce6C-1v8bA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.58A 3ce6D-1v8bA:
58.1		 3ce6D-1v8bA:
54.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 HIS A  54
THR A  56
ASP A 134
THR A 201
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.34A 3ce6D-1v8bA:
58.1		 3ce6D-1v8bA:
54.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 4 LEU A 218
ASP A 129
VAL A 197
THR A 139
 None
 1.01A 3cyxB-1v8bA:
undetectable		 3cyxB-1v8bA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 PRO A  15
THR A  98
VAL A  99
LYS A   5
 None
 1.17A 3elzA-1v8bA:
undetectable		 3elzA-1v8bA:
14.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 LEU A  53
HIS A  54
ASP A 134
GLU A 200
ASN A 235
LEU A 389
LEU A 392
GLY A 397
HIS A 398
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
NAD  A 501 (-3.4A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
 0.89A 3g1uA-1v8bA:
55.2		 3g1uA-1v8bA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.64A 3g1uA-1v8bA:
55.2		 3g1uA-1v8bA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 LEU A  53
ASP A 134
THR A 201
LEU A 392
HIS A 398
 None
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.33A 3g1uB-1v8bA:
55.2		 3g1uB-1v8bA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
THR A 201
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.48A 3g1uB-1v8bA:
55.2		 3g1uB-1v8bA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
 0.79A 3g1uC-1v8bA:
55.1		 3g1uC-1v8bA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 HIS A  54
ASP A 134
LYS A 230
ASP A 234
LEU A 389
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
 1.41A 3g1uC-1v8bA:
55.1		 3g1uC-1v8bA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 (-3.6A)
None
 0.47A 3g1uC-1v8bA:
55.1		 3g1uC-1v8bA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 LEU A  53
ASP A 134
THR A 201
ASP A 234
LEU A 392
 None
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
 1.17A 3g1uD-1v8bA:
55.7		 3g1uD-1v8bA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
THR A 201
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.43A 3g1uD-1v8bA:
55.7		 3g1uD-1v8bA:
51.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 LEU A  53
ASP A 134
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 None
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.23A 3glqA-1v8bA:
57.4		 3glqA-1v8bA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.42A 3glqA-1v8bA:
57.4		 3glqA-1v8bA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 LEU A  53
ASP A 134
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 None
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.20A 3glqB-1v8bA:
57.5		 3glqB-1v8bA:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.43A 3glqB-1v8bA:
57.5		 3glqB-1v8bA:
51.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 11 GLY A 264
GLY A 266
GLU A 287
ILE A 288
ASP A 289
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.5A)
NAD  A 501 (-2.9A)
NAD  A 501 (-4.1A)
NAD  A 501 (-4.9A)
 0.65A 3grvA-1v8bA:
4.4		 3grvA-1v8bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 GLY A 264
GLY A 266
GLU A 287
ILE A 288
ASP A 289
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.5A)
NAD  A 501 (-2.9A)
NAD  A 501 (-4.1A)
NAD  A 501 (-4.9A)
 0.66A 3gryA-1v8bA:
4.5		 3gryA-1v8bA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		8 / 10 LEU A  53
HIS A  54
THR A  56
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.20A 3h9uA-1v8bA:
55.1		 3h9uA-1v8bA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		8 / 10 HIS A  54
THR A  56
ASN A 391
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.28A 3h9uB-1v8bA:
55.1		 3h9uB-1v8bA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		8 / 10 LEU A  53
HIS A  54
THR A  56
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.21A 3h9uC-1v8bA:
55.2		 3h9uC-1v8bA:
51.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		8 / 10 LEU A  53
HIS A  54
THR A  56
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.21A 3h9uD-1v8bA:
55.3		 3h9uD-1v8bA:
51.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 10 VAL A 132
GLY A  51
TRP A 418
GLN A 419
ILE A  63
 None
 1.11A 3km6A-1v8bA:
undetectable		 3km6A-1v8bA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 11 ILE A 131
THR A 139
ILE A 195
ASN A 428
PRO A 128
 None
 1.21A 3kpcA-1v8bA:
undetectable		 3kpcA-1v8bA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 11 ILE A 262
ILE A 255
SER A 256
ALA A 273
GLY A 280
 None
 0.96A 3kw4A-1v8bA:
0.5		 3kw4A-1v8bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 11 THR A 251
LEU A 384
LEU A 390
GLY A 341
VAL A 260
 None
 1.19A 3lxiB-1v8bA:
undetectable		 3lxiB-1v8bA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 LEU A  53
ASP A 134
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 None
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.20A 3n58A-1v8bA:
57.7		 3n58A-1v8bA:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.40A 3n58A-1v8bA:
57.7		 3n58A-1v8bA:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 ASP A 134
THR A 201
LYS A 230
ASP A 234
LEU A 392
 ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
 1.09A 3n58C-1v8bA:
57.6		 3n58C-1v8bA:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
THR A 201
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.43A 3n58C-1v8bA:
57.6		 3n58C-1v8bA:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
THR A 201
LYS A 230
ASP A 234
LEU A 389
LEU A 392
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.38A 3n58D-1v8bA:
60.7		 3n58D-1v8bA:
54.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.46A 3ondA-1v8bA:
59.0		 3ondA-1v8bA:
57.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
THR A 201
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.31A 3ondA-1v8bA:
59.0		 3ondA-1v8bA:
57.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.36A 3ondB-1v8bA:
57.6		 3ondB-1v8bA:
57.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
THR A 201
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.30A 3ondB-1v8bA:
57.6		 3ondB-1v8bA:
57.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 11 GLY A 269
ASP A 267
GLY A 266
VAL A 236
CYH A 292
 None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.5A)
None
NAD  A 501 (-3.4A)
 1.13A 4c5lA-1v8bA:
4.4		 4c5lA-1v8bA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 9 GLY A 269
ASP A 267
GLY A 266
VAL A 236
CYH A 292
 None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.5A)
None
NAD  A 501 (-3.4A)
 1.14A 4c5lB-1v8bA:
undetectable		 4c5lB-1v8bA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 7 GLY A 269
ASP A 267
GLY A 266
VAL A 236
 None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.5A)
None
 0.78A 4c5nA-1v8bA:
5.1		 4c5nA-1v8bA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 8 GLY A 269
ASP A 267
GLY A 266
VAL A 236
 None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.5A)
None
 0.77A 4c5nC-1v8bA:
5.9		 4c5nC-1v8bA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 9 THR A 251
LEU A 384
LEU A 390
GLY A 341
VAL A 260
 None
 1.17A 4c9pA-1v8bA:
undetectable		 4c9pA-1v8bA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 10 THR A 251
LEU A 384
LEU A 390
GLY A 341
VAL A 260
 None
 1.22A 4c9pB-1v8bA:
undetectable		 4c9pB-1v8bA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 PHE A 405
ALA A 442
LEU A 446
ARG A  33
PHE A 401
 None
 0.85A 4dm8B-1v8bA:
undetectable		 4dm8B-1v8bA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 6 SER A  24
GLY A 238
ASP A 234
GLY A 397
 None
None
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.7A)
 1.03A 4koeA-1v8bA:
0.0
4koeB-1v8bA:
0.0
4koeC-1v8bA:
undetectable		 4koeA-1v8bA:
23.99
4koeB-1v8bA:
23.99
4koeC-1v8bA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.46A 4lvcA-1v8bA:
60.4		 4lvcA-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.27A 4lvcA-1v8bA:
60.4		 4lvcA-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.24A 4lvcB-1v8bA:
58.8		 4lvcB-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.46A 4lvcC-1v8bA:
59.9		 4lvcC-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.26A 4lvcC-1v8bA:
59.9		 4lvcC-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.26A 4pfjA-1v8bA:
56.8		 4pfjA-1v8bA:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 7 GLU A  58
THR A 201
LEU A 389
ASN A 391
SER A 406
 ADN  A 502 (-3.6A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 4.5A)
 0.56A 4pfjA-1v8bA:
56.8		 4pfjA-1v8bA:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.64A 4pfjB-1v8bA:
55.2		 4pfjB-1v8bA:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
ASN A 391
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 3.5A)
 1.44A 4pgfA-1v8bA:
56.7		 4pgfA-1v8bA:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
ASN A 391
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.45A 4pgfA-1v8bA:
56.7		 4pgfA-1v8bA:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 6 THR A  56
GLU A  58
THR A 201
LEU A 392
 ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
NAD  A 501 ( 2.8A)
ADN  A 502 ( 4.9A)
 0.24A 4pgfA-1v8bA:
56.7		 4pgfA-1v8bA:
51.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
GLU A  58
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.66A 4pgfB-1v8bA:
29.8		 4pgfB-1v8bA:
51.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 SER A  82
ASP A 134
GLY A 135
ASP A 137
LEU A 140
 None
ADN  A 502 (-3.1A)
None
None
None
 1.42A 4pghB-1v8bA:
2.1		 4pghB-1v8bA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 SER A 275
SER A 242
ASP A 234
TYR A 265
GLY A 269
 None
NAD  A 501 ( 4.8A)
ADN  A 502 (-2.8A)
None
None
 1.39A 4qb9E-1v8bA:
undetectable		 4qb9E-1v8bA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 8 ILE A  49
LEU A  31
LEU A  61
ILE A  63
 None
 0.93A 4xtaB-1v8bA:
undetectable		 4xtaB-1v8bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 VAL A 304
ASP A 311
ILE A 309
GLY A 313
VAL A 340
 None
 0.95A 4y8wA-1v8bA:
0.1		 4y8wA-1v8bA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 VAL A 304
ASP A 311
ILE A 309
GLY A 313
VAL A 340
 None
 0.96A 4y8wB-1v8bA:
undetectable		 4y8wB-1v8bA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 6 GLY A 238
ASP A 234
GLY A 397
SER A  24
 None
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.7A)
None
 1.04A 4z53A-1v8bA:
undetectable
4z53B-1v8bA:
undetectable		 4z53A-1v8bA:
21.68
4z53B-1v8bA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.38A 5axaA-1v8bA:
55.6		 5axaA-1v8bA:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.25A 5axaA-1v8bA:
55.6		 5axaA-1v8bA:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
THR A 201
HIS A 345
LEU A 389
 ADN  A 502 (-3.6A)
NAD  A 501 ( 2.8A)
NAD  A 501 (-4.8A)
NAD  A 501 ( 3.8A)
 0.31A 5axaA-1v8bA:
55.6		 5axaA-1v8bA:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.49A 5axaC-1v8bA:
55.5		 5axaC-1v8bA:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.26A 5axaC-1v8bA:
55.5		 5axaC-1v8bA:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
THR A 201
HIS A 345
LEU A 389
 ADN  A 502 (-3.6A)
NAD  A 501 ( 2.8A)
NAD  A 501 (-4.8A)
NAD  A 501 ( 3.8A)
 0.23A 5axaC-1v8bA:
55.5		 5axaC-1v8bA:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 ASP A 134
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.45A 5axdA-1v8bA:
55.7		 5axdA-1v8bA:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
GLU A  58
ASP A 134
GLU A 200
THR A 201
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
 0.21A 5axdA-1v8bA:
55.7		 5axdA-1v8bA:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 ASP A 134
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.47A 5axdC-1v8bA:
55.6		 5axdC-1v8bA:
53.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
GLU A  58
ASP A 134
GLU A 200
THR A 201
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
 0.21A 5axdC-1v8bA:
55.6		 5axdC-1v8bA:
53.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 LEU A 433
THR A  65
LEU A  69
ILE A 195
VAL A 441
 None
 1.31A 5dlvB-1v8bA:
undetectable		 5dlvB-1v8bA:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 HIS A  54
ASP A 134
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.50A 5hm8A-1v8bA:
56.0		 5hm8A-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.21A 5hm8A-1v8bA:
56.0		 5hm8A-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
GLU A 200
THR A 201
LEU A 389
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
 0.18A 5hm8A-1v8bA:
56.0		 5hm8A-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.21A 5hm8B-1v8bA:
56.0		 5hm8B-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
GLU A 200
THR A 201
LEU A 389
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
 0.18A 5hm8B-1v8bA:
56.0		 5hm8B-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.21A 5hm8C-1v8bA:
56.5		 5hm8C-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
GLU A 200
THR A 201
LEU A 389
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
 0.18A 5hm8C-1v8bA:
56.5		 5hm8C-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 HIS A  54
ASP A 134
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.50A 5hm8D-1v8bA:
56.1		 5hm8D-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.20A 5hm8D-1v8bA:
56.1		 5hm8D-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
GLU A 200
THR A 201
LEU A 389
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
 0.18A 5hm8D-1v8bA:
56.1		 5hm8D-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.21A 5hm8E-1v8bA:
56.3		 5hm8E-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
GLU A 200
THR A 201
LEU A 389
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
 0.17A 5hm8E-1v8bA:
56.3		 5hm8E-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 HIS A  54
ASP A 134
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.50A 5hm8F-1v8bA:
56.1		 5hm8F-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.21A 5hm8F-1v8bA:
56.1		 5hm8F-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
GLU A 200
THR A 201
LEU A 389
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
 0.17A 5hm8F-1v8bA:
56.1		 5hm8F-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 HIS A  54
ASP A 134
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.50A 5hm8G-1v8bA:
55.9		 5hm8G-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.21A 5hm8G-1v8bA:
55.9		 5hm8G-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
GLU A 200
THR A 201
LEU A 389
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
 0.45A 5hm8G-1v8bA:
55.9		 5hm8G-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.22A 5hm8H-1v8bA:
56.5		 5hm8H-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A  58
GLU A 200
THR A 201
LEU A 389
 ADN  A 502 (-3.6A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 ( 3.8A)
 0.17A 5hm8H-1v8bA:
56.5		 5hm8H-1v8bA:
52.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 9 LEU A 389
ASN A 342
ILE A 262
GLY A 264
ILE A 343
 NAD  A 501 ( 3.8A)
None
None
NAD  A 501 (-3.6A)
NAD  A 501 (-4.4A)
 1.10A 5kqxB-1v8bA:
undetectable		 5kqxB-1v8bA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 PHE A 405
ALA A 442
LEU A 446
ARG A  33
PHE A 401
 None
 0.78A 5m24A-1v8bA:
0.0		 5m24A-1v8bA:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.34A 5m5kA-1v8bA:
60.4		 5m5kA-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.26A 5m5kA-1v8bA:
60.4		 5m5kA-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
THR A 201
LYS A 230
ASP A 234
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.41A 5m5kB-1v8bA:
60.3		 5m5kB-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.47A 5m5kC-1v8bA:
57.0		 5m5kC-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.25A 5m5kC-1v8bA:
57.0		 5m5kC-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
THR A 201
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.27A 5m66A-1v8bA:
59.7		 5m66A-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.45A 5m66B-1v8bA:
59.5		 5m66B-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.27A 5m66B-1v8bA:
59.5		 5m66B-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 HIS A  54
THR A  56
ASP A 134
THR A 201
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.31A 5m66C-1v8bA:
59.7		 5m66C-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.47A 5m66D-1v8bA:
59.4		 5m66D-1v8bA:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M66_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.25A 5m66D-1v8bA:
59.4		 5m66D-1v8bA:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 8 THR A 320
ASP A 234
VAL A 205
GLY A 204
 NAD  A 501 (-3.8A)
ADN  A 502 (-2.8A)
None
None
 0.83A 5nzyA-1v8bA:
2.3		 5nzyA-1v8bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 8 SER A 256
ILE A 255
LEU A 279
MET A 248
 None
 0.83A 5u4sB-1v8bA:
7.9		 5u4sB-1v8bA:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 ASP A 134
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.40A 5utuF-1v8bA:
56.2		 5utuF-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
THR A 201
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.24A 5utuF-1v8bA:
56.2		 5utuF-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 THR A 202
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 NAD  A 501 (-3.2A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.32A 5utuF-1v8bA:
56.2		 5utuF-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		5 / 12 ASP A 134
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.41A 5utuH-1v8bA:
56.7		 5utuH-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
GLU A  58
ASP A 134
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.6A)
ADN  A 502 (-3.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.23A 5utuH-1v8bA:
56.7		 5utuH-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLU A 200
THR A 201
HIS A 345
LEU A 389
 ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
NAD  A 501 (-4.8A)
NAD  A 501 ( 3.8A)
 0.37A 5utuH-1v8bA:
56.7		 5utuH-1v8bA:
52.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.46A 5v96A-1v8bA:
60.9		 5v96A-1v8bA:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.25A 5v96A-1v8bA:
60.9		 5v96A-1v8bA:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.38A 5v96B-1v8bA:
61.0		 5v96B-1v8bA:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.27A 5v96B-1v8bA:
61.0		 5v96B-1v8bA:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.47A 5v96C-1v8bA:
61.1		 5v96C-1v8bA:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.25A 5v96C-1v8bA:
61.1		 5v96C-1v8bA:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.46A 5v96D-1v8bA:
61.0		 5v96D-1v8bA:
55.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.26A 5v96D-1v8bA:
61.0		 5v96D-1v8bA:
55.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 PRO A 471
GLY A 470
ASN A 467
LYS A 468
 None
 1.04A 5x23A-1v8bA:
undetectable		 5x23A-1v8bA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 6 PRO A 471
GLY A 470
ASN A 467
LYS A 468
 None
 0.96A 5x24A-1v8bA:
0.6		 5x24A-1v8bA:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 LEU A  53
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 None
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.18A 6aphA-1v8bA:
54.9		 6aphA-1v8bA:
51.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.46A 6aphA-1v8bA:
54.9		 6aphA-1v8bA:
51.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLN A 410
THR A 411
HIS A 436
LEU A 433
 None
 1.33A 6aphA-1v8bA:
54.9		 6aphA-1v8bA:
51.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 HIS A  54
THR A  56
ASP A 234
ASN A 391
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.33A 6exiA-1v8bA:
59.1		 6exiA-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 10 GLY A 264
GLY A 266
GLU A 287
ASP A 289
CYH A 292
THR A 320
ASN A 322
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.5A)
NAD  A 501 (-2.9A)
NAD  A 501 (-4.9A)
NAD  A 501 (-3.4A)
NAD  A 501 (-3.8A)
NAD  A 501 (-3.8A)
 0.16A 6exiA-1v8bA:
59.1		 6exiA-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		3 / 3 LEU A 456
GLN A 460
LYS A 473
 None
 0.40A 6exiB-1v8bA:
55.2		 6exiB-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 HIS A  54
THR A  56
LYS A 230
ASP A 234
ASN A 391
LEU A 392
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.71A 6exiB-1v8bA:
55.2		 6exiB-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		3 / 3 LEU A 456
GLN A 460
LYS A 473
 None
 0.43A 6exiA-1v8bA:
59.1		 6exiA-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 10 GLY A 264
GLY A 266
GLU A 287
ASP A 289
CYH A 292
THR A 320
ASN A 322
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.5A)
NAD  A 501 (-2.9A)
NAD  A 501 (-4.9A)
NAD  A 501 (-3.4A)
NAD  A 501 (-3.8A)
NAD  A 501 (-3.8A)
 0.19A 6exiB-1v8bA:
55.2		 6exiB-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		8 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 234
ASN A 391
LEU A 392
HIS A 398
MET A 403
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
 0.31A 6exiC-1v8bA:
55.8		 6exiC-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		3 / 3 LEU A 389
GLY A 397
PHE A 407
 NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
None
 0.26A 6exiC-1v8bA:
55.8		 6exiC-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 GLY A 264
GLY A 266
GLU A 287
ASP A 289
CYH A 292
THR A 320
ASN A 322
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.5A)
NAD  A 501 (-2.9A)
NAD  A 501 (-4.9A)
NAD  A 501 (-3.4A)
NAD  A 501 (-3.8A)
NAD  A 501 (-3.8A)
 0.18A 6exiC-1v8bA:
55.8
6exiD-1v8bA:
55.0		 6exiC-1v8bA:
11.36
6exiD-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		9 / 12 HIS A  54
THR A  56
ASP A 234
ASN A 391
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 (-3.0A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.40A 6exiD-1v8bA:
55.0		 6exiD-1v8bA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 GLY A 264
GLY A 266
GLU A 287
ASP A 289
CYH A 292
THR A 320
ASN A 322
 NAD  A 501 (-3.6A)
NAD  A 501 (-3.5A)
NAD  A 501 (-2.9A)
NAD  A 501 (-4.9A)
NAD  A 501 (-3.4A)
NAD  A 501 (-3.8A)
NAD  A 501 (-3.8A)
 0.19A 6exiC-1v8bA:
55.8
6exiD-1v8bA:
55.0		 6exiC-1v8bA:
11.36
6exiD-1v8bA:
11.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.08A 6f3mA-1v8bA:
51.5		 6f3mA-1v8bA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_A_ADNA502_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.43A 6f3mA-1v8bA:
51.5		 6f3mA-1v8bA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.49A 6f3mB-1v8bA:
35.2		 6f3mB-1v8bA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_B_ADNB502_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.33A 6f3mB-1v8bA:
35.2		 6f3mB-1v8bA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		6 / 12 ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.10A 6f3mC-1v8bA:
50.6		 6f3mC-1v8bA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_C_ADNC502_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.43A 6f3mC-1v8bA:
50.6		 6f3mC-1v8bA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.48A 6f3mD-1v8bA:
50.7		 6f3mD-1v8bA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3M_D_ADND502_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		11 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.32A 6f3mD-1v8bA:
50.7		 6f3mD-1v8bA:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.50A 6f3nA-1v8bA:
50.7		 6f3nA-1v8bA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_A_ADNA505_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.46A 6f3nA-1v8bA:
50.7		 6f3nA-1v8bA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.49A 6f3nB-1v8bA:
50.7		 6f3nB-1v8bA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_B_ADNB505_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
THR A 201
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
NAD  A 501 ( 2.8A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.34A 6f3nB-1v8bA:
50.7		 6f3nB-1v8bA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_C_ADNC505_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.38A 6f3nC-1v8bA:
50.7		 6f3nC-1v8bA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.49A 6f3nD-1v8bA:
51.6		 6f3nD-1v8bA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F3N_D_ADND506_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.46A 6f3nD-1v8bA:
51.6		 6f3nD-1v8bA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.49A 6gbnA-1v8bA:
54.6		 6gbnA-1v8bA:
49.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_A_ADNA501_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.24A 6gbnA-1v8bA:
54.6		 6gbnA-1v8bA:
49.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
 1.37A 6gbnB-1v8bA:
57.3		 6gbnB-1v8bA:
49.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.27A 6gbnB-1v8bA:
57.3		 6gbnB-1v8bA:
49.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_B_ADNB501_2
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 GLN A 410
THR A 411
HIS A 436
LEU A 433
 None
 1.30A 6gbnB-1v8bA:
57.3		 6gbnB-1v8bA:
49.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_C_ADNC501_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
LEU A 392
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.27A 6gbnC-1v8bA:
54.8		 6gbnC-1v8bA:
49.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		7 / 12 HIS A  54
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 389
HIS A 398
 ADN  A 502 (-4.1A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
NAD  A 501 ( 3.8A)
ADN  A 502 ( 3.5A)
 1.49A 6gbnD-1v8bA:
54.1		 6gbnD-1v8bA:
49.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GBN_D_ADND501_1
(-)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		12 / 12 LEU A  53
HIS A  54
THR A  56
ASP A 134
GLU A 200
LYS A 230
ASP A 234
LEU A 392
GLY A 397
HIS A 398
MET A 403
PHE A 407
 None
ADN  A 502 (-4.1A)
ADN  A 502 (-3.0A)
ADN  A 502 (-3.1A)
ADN  A 502 (-4.0A)
ADN  A 502 (-3.0A)
ADN  A 502 (-2.8A)
ADN  A 502 ( 4.9A)
ADN  A 502 ( 3.7A)
ADN  A 502 ( 3.5A)
ADN  A 502 (-3.6A)
None
 0.25A 6gbnD-1v8bA:
54.1		 6gbnD-1v8bA:
49.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1v8b ADENOSYLHOMOCYSTEINA
SE
(Plasmodium
falciparum) 		4 / 5 ASN A 342
GLY A 204
HIS A 345
ASP A 348
 None
None
NAD  A 501 (-4.8A)
None
 1.18A 6gh9A-1v8bA:
undetectable		 6gh9A-1v8bA:
12.47