SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1v8y ADP-RIBOSE
PYROPHOSPHATASE
(Thermus
thermophilus) 		4 / 8 GLY A  67
ILE A  19
ALA A  78
GLU A  70
 ZN  A 300 ( 4.5A)
APR  A 619 (-4.5A)
None
ZN  A 301 (-2.3A)
 0.93A 2x0pA-1v8yA:
undetectable		 2x0pA-1v8yA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1v8y ADP-RIBOSE
PYROPHOSPHATASE
(Thermus
thermophilus) 		4 / 7 ILE A  64
PRO A  65
GLY A  88
ALA A  41
 None
 0.88A 4g0uB-1v8yA:
undetectable		 4g0uB-1v8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 1v8y ADP-RIBOSE
PYROPHOSPHATASE
(Thermus
thermophilus) 		5 / 11 LEU A 167
TYR A 162
GLY A 156
ILE A  40
PRO A 138
 None
 1.30A 5hjiA-1v8yA:
undetectable		 5hjiA-1v8yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1v8y ADP-RIBOSE
PYROPHOSPHATASE
(Thermus
thermophilus) 		3 / 3 LEU A  76
ASN A 117
LEU A  83
 None
 0.68A 6exiA-1v8yA:
undetectable		 6exiA-1v8yA:
23.24