SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v93'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A 162
LEU A 163
PHE A 166
LYS A 167
ILE A 204
 FAD  A 300 ( 4.9A)
DIO  A 304 ( 4.5A)
None
DIO  A 304 ( 4.6A)
None
 1.24A 1dreA-1v93A:
undetectable		 1dreA-1v93A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_B_BZMB600_0
(ODORANT-BINDING
PROTEIN)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 ILE A 178
VAL A 100
ASN A 102
GLY A 146
LEU A 106
 FAD  A 300 (-3.7A)
None
None
None
FAD  A 300 (-4.0A)
 1.13A 1dzmB-1v93A:
0.0		 1dzmB-1v93A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A 162
LEU A 163
PHE A 166
LYS A 167
ILE A 204
 FAD  A 300 ( 4.9A)
DIO  A 304 ( 4.5A)
None
DIO  A 304 ( 4.6A)
None
 1.19A 1jolA-1v93A:
undetectable		 1jolA-1v93A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A 162
LEU A 163
PHE A 166
LYS A 167
ILE A 204
 FAD  A 300 ( 4.9A)
DIO  A 304 ( 4.5A)
None
DIO  A 304 ( 4.6A)
None
 1.25A 1rh3A-1v93A:
undetectable		 1rh3A-1v93A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A 162
LEU A 163
PHE A 166
LYS A 167
ILE A 204
 FAD  A 300 ( 4.9A)
DIO  A 304 ( 4.5A)
None
DIO  A 304 ( 4.6A)
None
 1.03A 1tdrA-1v93A:
undetectable		 1tdrA-1v93A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ILE A 204
LEU A 205
ALA A 148
GLY A 146
LEU A  75
 None
 1.22A 2a58A-1v93A:
2.1
2a58B-1v93A:
undetectable		 2a58A-1v93A:
20.96
2a58B-1v93A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ILE A 204
LEU A 205
ALA A 148
GLY A 146
LEU A  75
 None
 1.24A 2a58B-1v93A:
undetectable
2a58C-1v93A:
2.0		 2a58B-1v93A:
20.96
2a58C-1v93A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ILE A 204
LEU A 205
ALA A 148
GLY A 146
LEU A  75
 None
 1.22A 2a58D-1v93A:
undetectable
2a58E-1v93A:
2.1		 2a58D-1v93A:
20.96
2a58E-1v93A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 ALA A 279
THR A 212
PHE A 271
 None
None
DIO  A 301 (-4.9A)
 0.79A 2c6nB-1v93A:
undetectable		 2c6nB-1v93A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 ALA A 172
ILE A 134
ALA A 127
ALA A 105
VAL A 144
 None
None
FAD  A 300 (-3.3A)
None
None
 1.06A 2qhfA-1v93A:
undetectable		 2qhfA-1v93A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		4 / 8 ALA A 259
LEU A 261
ALA A 264
PHE A 189
 None
 0.83A 2vcvF-1v93A:
undetectable		 2vcvF-1v93A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		4 / 6 ASP A 175
VAL A 131
ARG A 135
ILE A 134
 None
 1.12A 2yfbB-1v93A:
undetectable		 2yfbB-1v93A:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		7 / 9 GLU A  18
HIS A  77
LEU A 104
ALA A 147
ILE A 178
HIS A 270
TYR A 272
 FAD  A 300 ( 4.4A)
FAD  A 300 (-4.0A)
None
FAD  A 300 (-3.4A)
FAD  A 300 (-3.7A)
None
None
 0.51A 3aptB-1v93A:
36.8		 3aptB-1v93A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 THR A  49
ASP A 109
GLN A 180
SER A 213
TYR A 272
 FAD  A 300 (-3.8A)
FAD  A 300 (-3.3A)
FAD  A 300 (-4.3A)
None
None
 1.18A 3fsuE-1v93A:
35.2		 3fsuE-1v93A:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 11 THR A  49
ASP A 109
GLN A 180
TYR A 272
LEU A 274
 FAD  A 300 (-3.8A)
FAD  A 300 (-3.3A)
FAD  A 300 (-4.3A)
None
None
 0.75A 3fsuE-1v93A:
35.2		 3fsuE-1v93A:
35.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 LYS A 276
SER A 213
GLN A 216
 None
 1.18A 3si7A-1v93A:
undetectable		 3si7A-1v93A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 ASP A 162
LEU A 163
PHE A 166
 FAD  A 300 ( 4.9A)
DIO  A 304 ( 4.5A)
None
 0.54A 4pthA-1v93A:
undetectable		 4pthA-1v93A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 ASP A 162
LEU A 163
PHE A 166
LYS A 167
ILE A 204
 FAD  A 300 ( 4.9A)
DIO  A 304 ( 4.5A)
None
DIO  A 304 ( 4.6A)
None
 1.15A 4qlgA-1v93A:
undetectable		 4qlgA-1v93A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		4 / 7 ALA A 127
GLY A 173
ALA A 172
GLU A 171
 FAD  A 300 (-3.3A)
None
None
None
 0.87A 4r1zB-1v93A:
undetectable		 4r1zB-1v93A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 PRO A 203
ALA A 177
ILE A 202
THR A  49
GLU A  18
 None
None
None
FAD  A 300 (-3.8A)
FAD  A 300 ( 4.4A)
 1.42A 5ewjC-1v93A:
undetectable
5ewjD-1v93A:
undetectable		 5ewjC-1v93A:
21.70
5ewjD-1v93A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 TYR A 272
TYR A 149
GLN A 180
 None
FAD  A 300 (-4.3A)
FAD  A 300 (-4.3A)
 1.00A 5jsdA-1v93A:
undetectable
5jsdB-1v93A:
undetectable		 5jsdA-1v93A:
17.58
5jsdB-1v93A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		3 / 3 TYR A 272
TYR A 149
GLN A 180
 None
FAD  A 300 (-4.3A)
FAD  A 300 (-4.3A)
 1.00A 5jsdB-1v93A:
undetectable
5jsdC-1v93A:
undetectable		 5jsdB-1v93A:
17.58
5jsdC-1v93A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A  54
GLY A  51
LEU A  78
THR A  56
ALA A  81
 None
 0.93A 5kpcA-1v93A:
undetectable		 5kpcA-1v93A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.41A 5ksgB-1v93A:
0.0		 5ksgB-1v93A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.44A 5ksnA-1v93A:
0.0		 5ksnA-1v93A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.41A 5ksnB-1v93A:
0.0		 5ksnB-1v93A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.41A 5kt8B-1v93A:
0.0		 5kt8B-1v93A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.41A 5sxsB-1v93A:
0.0		 5sxsB-1v93A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 8 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.44A 5sxtA-1v93A:
undetectable		 5sxtA-1v93A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 8 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.43A 5sxtB-1v93A:
undetectable		 5sxtB-1v93A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.42A 5syiB-1v93A:
0.0		 5syiB-1v93A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 8 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.37A 5syjB-1v93A:
undetectable		 5syjB-1v93A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.41A 6cdqA-1v93A:
0.0		 6cdqA-1v93A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.39A 6cdqB-1v93A:
0.0		 6cdqB-1v93A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE
(Thermus
thermophilus) 		5 / 9 GLU A  18
GLY A 207
GLN A 180
LEU A 181
THR A 179
 FAD  A 300 ( 4.4A)
None
FAD  A 300 (-4.3A)
None
None
 1.41A 6cfqB-1v93A:
0.0		 6cfqB-1v93A:
14.24