SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A  17
LEU A  36
GLY A  84
LEU A  82
 None
SAH  A 501 ( 4.9A)
SAH  A 501 (-4.9A)
None
 0.93A 1gtiA-1v9aA:
undetectable		 1gtiA-1v9aA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 PHE A 185
ARG A 164
ILE A 168
SER A 136
GLY A 207
 None
 1.18A 2lbdA-1v9aA:
undetectable		 2lbdA-1v9aA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ARG A  92
GLY A  93
GLU A  95
SER A 115
 None
None
None
SAH  A 501 (-2.6A)
 0.77A 2xctS-1v9aA:
0.3
2xctU-1v9aA:
2.5		 2xctS-1v9aA:
17.32
2xctU-1v9aA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 THR A  18
GLY A  85
GLY A 112
LEU A  16
VAL A  37
 None
SAH  A 501 (-3.5A)
None
None
None
 1.25A 3fzgA-1v9aA:
undetectable		 3fzgA-1v9aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 LEU A 219
GLU A 181
PRO A 182
ARG A 177
 None
 1.21A 3ltwA-1v9aA:
undetectable		 3ltwA-1v9aA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 172
ALA A 199
THR A 183
GLY A 137
 None
 0.69A 3ny4A-1v9aA:
undetectable		 3ny4A-1v9aA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 ALA A  45
VAL A  37
VAL A  41
LEU A  25
 None
 0.83A 3o14A-1v9aA:
undetectable		 3o14A-1v9aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 THR A  18
LEU A  17
LEU A  82
LEU A  25
 None
 0.73A 4z90F-1v9aA:
0.0
4z90G-1v9aA:
0.0
4z90H-1v9aA:
0.0
4z90I-1v9aA:
0.0
4z90J-1v9aA:
0.0		 4z90F-1v9aA:
19.52
4z90G-1v9aA:
19.52
4z90H-1v9aA:
19.52
4z90I-1v9aA:
19.52
4z90J-1v9aA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 SER A 115
ARG A  81
GLY A  93
GLU A  96
 SAH  A 501 (-2.6A)
None
None
None
 1.06A 5btaA-1v9aA:
undetectable
5btaB-1v9aA:
undetectable
5btaC-1v9aA:
undetectable		 5btaA-1v9aA:
20.86
5btaB-1v9aA:
24.73
5btaC-1v9aA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 SER A 115
ARG A  92
GLY A  93
GLU A  95
 SAH  A 501 (-2.6A)
None
None
None
 1.04A 5btaA-1v9aA:
undetectable
5btaB-1v9aA:
undetectable
5btaC-1v9aA:
undetectable		 5btaA-1v9aA:
20.86
5btaB-1v9aA:
24.73
5btaC-1v9aA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 SER A 115
ARG A  81
GLY A  93
GLU A  96
 SAH  A 501 (-2.6A)
None
None
None
 1.09A 5btcA-1v9aA:
0.0
5btcC-1v9aA:
0.0
5btcD-1v9aA:
undetectable		 5btcA-1v9aA:
20.86
5btcC-1v9aA:
20.86
5btcD-1v9aA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 SER A 115
ARG A  92
GLY A  93
GLU A  95
 SAH  A 501 (-2.6A)
None
None
None
 1.03A 5btcA-1v9aA:
0.0
5btcC-1v9aA:
0.0
5btcD-1v9aA:
undetectable		 5btcA-1v9aA:
20.86
5btcC-1v9aA:
20.86
5btcD-1v9aA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 SER A 115
ARG A  81
GLY A  93
GLU A  96
 SAH  A 501 (-2.6A)
None
None
None
 1.04A 5btcA-1v9aA:
0.0
5btcB-1v9aA:
undetectable
5btcC-1v9aA:
0.0		 5btcA-1v9aA:
20.86
5btcB-1v9aA:
24.73
5btcC-1v9aA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 SER A 115
ARG A  92
GLY A  93
GLU A  95
 SAH  A 501 (-2.6A)
None
None
None
 1.02A 5btcA-1v9aA:
0.0
5btcB-1v9aA:
undetectable
5btcC-1v9aA:
0.0		 5btcA-1v9aA:
20.86
5btcB-1v9aA:
24.73
5btcC-1v9aA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 SER A 115
ARG A  92
GLY A  93
GLU A  95
 SAH  A 501 (-2.6A)
None
None
None
 0.99A 5cdqA-1v9aA:
undetectable
5cdqB-1v9aA:
2.8
5cdqC-1v9aA:
undetectable		 5cdqA-1v9aA:
19.11
5cdqB-1v9aA:
22.69
5cdqC-1v9aA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 SER A 115
ARG A  92
GLY A  93
GLU A  95
 SAH  A 501 (-2.6A)
None
None
None
 0.98A 5cdqR-1v9aA:
undetectable
5cdqS-1v9aA:
2.7
5cdqT-1v9aA:
undetectable		 5cdqR-1v9aA:
19.11
5cdqS-1v9aA:
22.69
5cdqT-1v9aA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 VAL A 157
LEU A 123
ALA A 134
LEU A 216
 None
None
None
SAH  A 501 (-4.4A)
 0.64A 5jq7A-1v9aA:
undetectable		 5jq7A-1v9aA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  17
VAL A   7
PRO A  46
LEU A  44
TYR A  22
 None
 1.25A 6eliA-1v9aA:
undetectable		 6eliA-1v9aA:
17.95