SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 12 THR A 189
VAL A 193
GLY A 219
ALA A 298
ILE A 215
 NAD  A 430 (-3.4A)
None
NAD  A 430 (-3.4A)
None
None
 0.92A 1bx4A-1v9lA:
undetectable		 1bx4A-1v9lA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 217
ASP A 241
ILE A 242
ALA A 299
ILE A 300
 NAD  A 430 (-3.5A)
NAD  A 430 (-2.5A)
NAD  A 430 (-4.0A)
NAD  A 430 (-3.3A)
NAD  A 430 (-4.2A)
 0.79A 1cetA-1v9lA:
2.9		 1cetA-1v9lA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 4 VAL A 359
TRP A 364
TRP A 358
 None
 1.38A 1gmkC-1v9lA:
undetectable
1gmkD-1v9lA:
undetectable		 1gmkC-1v9lA:
3.64
1gmkD-1v9lA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 4 ILE A 332
LEU A 333
VAL A 340
ALA A 346
 None
 0.87A 1mz9A-1v9lA:
undetectable		 1mz9A-1v9lA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 5 ILE A 332
LEU A 333
VAL A 340
ALA A 346
 None
 0.95A 1mz9C-1v9lA:
undetectable		 1mz9C-1v9lA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 11 ALA A 314
THR A 325
PRO A 324
ALA A 234
VAL A 236
 None
 1.18A 1rv7A-1v9lA:
undetectable
1rv7B-1v9lA:
undetectable		 1rv7A-1v9lA:
14.73
1rv7B-1v9lA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		6 / 12 LEU A 345
ILE A 404
ALA A 403
VAL A 341
LEU A 204
MET A 200
 None
 1.38A 2g78A-1v9lA:
undetectable		 2g78A-1v9lA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ARG A 185
VAL A  72
THR A 148
 None
 0.76A 2nmzA-1v9lA:
undetectable		 2nmzA-1v9lA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ARG A 185
VAL A  72
THR A 148
 None
 0.80A 2nnkA-1v9lA:
undetectable		 2nnkA-1v9lA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 TRP A 224
VAL A 193
TRP A 228
 None
 1.27A 2xdcC-1v9lA:
undetectable
2xdcD-1v9lA:
undetectable		 2xdcC-1v9lA:
3.64
2xdcD-1v9lA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 TRP A 224
VAL A 193
TRP A 228
 None
 1.30A 2xdcE-1v9lA:
undetectable
2xdcF-1v9lA:
undetectable		 2xdcE-1v9lA:
3.64
2xdcF-1v9lA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 TRP A 224
VAL A 193
TRP A 228
 None
 1.28A 2y5mE-1v9lA:
undetectable
2y5mF-1v9lA:
undetectable		 2y5mE-1v9lA:
3.64
2y5mF-1v9lA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 TRP A 224
VAL A 193
TRP A 228
 None
 1.30A 2y6nC-1v9lA:
undetectable
2y6nD-1v9lA:
undetectable		 2y6nC-1v9lA:
3.64
2y6nD-1v9lA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 TRP A 224
VAL A 193
TRP A 228
 None
 1.30A 2y6nE-1v9lA:
undetectable
2y6nF-1v9lA:
undetectable		 2y6nE-1v9lA:
3.64
2y6nF-1v9lA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 11 CYH A  62
LEU A  31
ILE A  30
VAL A  10
LEU A   7
 None
 1.40A 3a9eB-1v9lA:
undetectable		 3a9eB-1v9lA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ARG A 185
VAL A  72
THR A 148
 None
 0.87A 3k4vA-1v9lA:
undetectable		 3k4vA-1v9lA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ALA A 194
ARG A 198
LYS A 202
 None
 0.62A 3kp3B-1v9lA:
0.0		 3kp3B-1v9lA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ALA A 194
ARG A 198
LYS A 202
 None
 0.78A 3kp5B-1v9lA:
undetectable		 3kp5B-1v9lA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ASN A 253
ASN A 277
GLU A 250
 None
 0.79A 3kpdC-1v9lA:
undetectable		 3kpdC-1v9lA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ASN A 253
ASN A 277
GLU A 250
 None
 0.94A 3kpdB-1v9lA:
undetectable		 3kpdB-1v9lA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ARG A 185
VAL A  72
THR A 148
 None
 0.78A 3pwrA-1v9lA:
undetectable		 3pwrA-1v9lA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 8 ALA A  87
VAL A  84
ASP A  83
LEU A  80
 None
 0.76A 3roxA-1v9lA:
6.4		 3roxA-1v9lA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 9 GLY A 320
ALA A 321
ILE A 300
GLY A 217
ILE A 304
 None
NAD  A 430 (-3.8A)
NAD  A 430 (-4.2A)
NAD  A 430 (-3.5A)
None
 1.01A 3s53A-1v9lA:
undetectable		 3s53A-1v9lA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ARG A 185
VAL A  72
THR A 148
 None
 0.85A 3tl9A-1v9lA:
undetectable		 3tl9A-1v9lA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 5 TYR A 160
VAL A 157
SER A 161
GLY A 170
 None
 1.44A 3v4tA-1v9lA:
0.0
3v4tD-1v9lA:
0.0		 3v4tA-1v9lA:
24.52
3v4tD-1v9lA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 12 GLY A 222
GLY A 219
ILE A 257
VAL A 296
VAL A 193
 None
NAD  A 430 (-3.4A)
None
None
None
 0.94A 4gc9A-1v9lA:
undetectable		 4gc9A-1v9lA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		4 / 8 TYR A  28
HIS A  61
LEU A 408
LEU A  92
 None
 1.04A 4jtrA-1v9lA:
undetectable		 4jtrA-1v9lA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 12 GLY A 192
ALA A 194
THR A 197
ILE A 215
VAL A 318
 None
 0.91A 4nkxB-1v9lA:
undetectable		 4nkxB-1v9lA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 SER A 240
ALA A 214
VAL A 213
 NAD  A 430 ( 4.0A)
None
None
 0.65A 4x20C-1v9lA:
undetectable		 4x20C-1v9lA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 12 GLY A  48
GLN A 117
GLU A 119
LEU A 115
LEU A 120
 None
 1.17A 5nwwA-1v9lA:
undetectable		 5nwwA-1v9lA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ARG A 400
PRO A 324
TYR A 334
 None
 1.09A 5tzoB-1v9lA:
undetectable		 5tzoB-1v9lA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		3 / 3 ILE A 141
ASN A  94
CYH A  62
 None
 0.87A 6bp4A-1v9lA:
undetectable		 6bp4A-1v9lA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		5 / 12 VAL A 303
LEU A 252
VAL A 236
PHE A 272
GLY A 219
 None
None
None
None
NAD  A 430 (-3.4A)
 1.41A 6brdA-1v9lA:
2.7		 6brdA-1v9lA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1v9l GLUTAMATE
DEHYDROGENASE
(Pyrobaculum
islandicum) 		6 / 12 GLY A 320
ALA A 321
VAL A 303
ILE A 300
GLY A 217
ILE A 215
 None
NAD  A 430 (-3.8A)
None
NAD  A 430 (-4.2A)
NAD  A 430 (-3.5A)
None
 1.43A 6dilB-1v9lA:
undetectable		 6dilB-1v9lA:
13.32