SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A  63
SER A 125
TYR A 134
PHE A 282
HIS A 280
 None
 1.35A 1maaC-1v9nA:
undetectable		 1maaC-1v9nA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A  92
ASP A  91
ASN A 126
 None
 0.65A 1vq1A-1v9nA:
undetectable		 1vq1A-1v9nA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A  19
ASP A  48
VAL A  14
ILE A 338
 None
 0.99A 2aoiB-1v9nA:
undetectable		 2aoiB-1v9nA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 250
TYR A 246
GLY A 242
 None
 0.60A 2ocuA-1v9nA:
undetectable		 2ocuA-1v9nA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A  90
PHE A 282
ARG A 103
GLY A 101
 None
 0.82A 2vdbA-1v9nA:
undetectable		 2vdbA-1v9nA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A  84
ILE A  81
VAL A  80
 None
 0.51A 3nv6A-1v9nA:
undetectable		 3nv6A-1v9nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 172
ALA A 135
ILE A 321
GLY A 323
HIS A 322
 None
None
None
NDP  A 401 (-3.2A)
NDP  A 401 (-3.3A)
 1.11A 3q95A-1v9nA:
undetectable		 3q95A-1v9nA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 8 GLY A 145
ALA A 173
GLY A 142
ILE A 287
THR A 176
 None
 1.44A 3so9A-1v9nA:
undetectable		 3so9A-1v9nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 179
PRO A 180
LEU A 182
 None
 0.84A 3tpxE-1v9nA:
undetectable		 3tpxE-1v9nA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A  51
GLY A  56
TYR A  63
LEU A  44
 None
 0.83A 4fgzA-1v9nA:
undetectable		 4fgzA-1v9nA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 101
VAL A  40
GLY A  95
PRO A  33
ILE A  39
 None
 1.00A 4njvC-1v9nA:
undetectable		 4njvC-1v9nA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  96
GLY A  97
GLN A  98
ILE A  90
VAL A 120
 None
 1.35A 4okwA-1v9nA:
undetectable		 4okwA-1v9nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 338
LEU A  44
ALA A  41
LEU A 348
ILE A 340
 None
 0.90A 4pssA-1v9nA:
undetectable		 4pssA-1v9nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 THR A 149
PRO A 169
ASP A 184
 NDP  A 401 ( 4.2A)
NDP  A 401 (-4.3A)
NDP  A 401 (-2.5A)
 0.72A 5l8dB-1v9nA:
undetectable		 5l8dB-1v9nA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		3 / 3 THR A 149
PRO A 169
ASP A 184
 NDP  A 401 ( 4.2A)
NDP  A 401 (-4.3A)
NDP  A 401 (-2.5A)
 0.72A 5mwuB-1v9nA:
undetectable		 5mwuB-1v9nA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 231
GLY A 242
GLY A 245
THR A 158
 GOL  A 403 (-4.3A)
None
None
GOL  A 403 (-3.7A)
 0.77A 5o96C-1v9nA:
undetectable		 5o96C-1v9nA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 1v9n MALATE DEHYDROGENASE
(Pyrococcus
horikoshii) 		5 / 10 PRO A  76
ILE A  90
VAL A  99
LEU A  96
SER A 125
 None
 1.41A 5tixB-1v9nA:
undetectable		 5tixB-1v9nA:
20.34