SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1v9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 11 ALA A  94
LEU A  71
LEU A  73
LEU A 129
ALA A  40
 None
 1.12A 1h9zA-1v9sA:
undetectable		 1h9zA-1v9sA:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 5 MET A 132
ALA A 134
TYR A 192
ILE A 193
ASP A 199
 None
SO4  A 517 (-3.3A)
None
None
SO4  A 514 ( 4.4A)
 0.58A 1upfA-1v9sA:
26.9		 1upfA-1v9sA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 7 MET A 132
ALA A 134
TYR A 192
ILE A 193
ASP A 199
 None
SO4  A 517 (-3.3A)
None
None
SO4  A 514 ( 4.4A)
 0.52A 1upfB-1v9sA:
26.8		 1upfB-1v9sA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 5 MET A 132
ALA A 134
TYR A 192
ILE A 193
ASP A 199
 None
SO4  A 517 (-3.3A)
None
None
SO4  A 514 ( 4.4A)
 0.47A 1upfC-1v9sA:
27.0		 1upfC-1v9sA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 4 MET A 132
ALA A 134
TYR A 192
ILE A 193
 None
SO4  A 517 (-3.3A)
None
None
 0.45A 1upfD-1v9sA:
27.7		 1upfD-1v9sA:
37.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 5 LEU A 117
GLY A  97
HIS A  98
ILE A  99
 None
 0.72A 1xf1A-1v9sA:
2.2		 1xf1A-1v9sA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 6 LEU A 117
GLY A  97
HIS A  98
ILE A  99
 None
 0.71A 1xf1B-1v9sA:
2.7		 1xf1B-1v9sA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 10 ALA A 142
ALA A 139
LEU A 133
LEU A 156
LEU A 146
 None
SO4  A 517 (-4.1A)
None
None
None
 1.22A 2bxeA-1v9sA:
undetectable		 2bxeA-1v9sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 11 MET A 132
VAL A  35
ALA A  32
LEU A  31
LEU A  15
 None
 1.09A 2c12F-1v9sA:
undetectable		 2c12F-1v9sA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 11 LEU A 101
LEU A 141
ILE A  99
LEU A 128
ASP A 130
 None
None
None
None
SO4  A 517 ( 4.1A)
 1.21A 2q6hA-1v9sA:
undetectable		 2q6hA-1v9sA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 11 LEU A 101
LEU A 141
ILE A  99
LEU A 128
ASP A 130
 None
None
None
None
SO4  A 517 ( 4.1A)
 1.22A 2qeiA-1v9sA:
undetectable		 2qeiA-1v9sA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 8 HIS A 173
LEU A 156
GLY A 136
ALA A 139
 SO4  A 518 (-3.9A)
None
SO4  A 517 (-3.3A)
SO4  A 517 (-4.1A)
 0.92A 2xfsA-1v9sA:
undetectable		 2xfsA-1v9sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 8 HIS A 173
LEU A 156
GLY A 136
ALA A 139
 SO4  A 518 (-3.9A)
None
SO4  A 517 (-3.3A)
SO4  A 517 (-4.1A)
 0.91A 2xh9A-1v9sA:
undetectable		 2xh9A-1v9sA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		6 / 12 GLY A  80
ILE A  99
ALA A  36
VAL A  74
LEU A  73
LEU A  88
 None
 1.40A 2yqzA-1v9sA:
2.0		 2yqzA-1v9sA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		6 / 12 GLY A  80
ALA A  36
VAL A  74
LEU A  73
LEU A  88
VAL A  91
 None
 1.31A 2yqzB-1v9sA:
3.4		 2yqzB-1v9sA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		6 / 12 GLY A  80
ILE A  99
ALA A  36
VAL A  74
LEU A  73
LEU A  88
 None
 1.38A 2yqzB-1v9sA:
3.4		 2yqzB-1v9sA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 12 GLY A  86
LEU A  88
LEU A  81
GLU A  34
ALA A  36
 None
 1.14A 3kkzA-1v9sA:
3.3		 3kkzA-1v9sA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 7 GLU A  42
HIS A   8
VAL A  11
ALA A  40
 None
 0.89A 3kp6B-1v9sA:
0.0		 3kp6B-1v9sA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 5 ILE A 121
ILE A  99
HIS A  98
VAL A  74
 None
 0.97A 5jmnA-1v9sA:
undetectable		 5jmnA-1v9sA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 6 PHE A  28
PRO A  25
GLY A  24
THR A  23
 None
 0.92A 5x24A-1v9sA:
undetectable		 5x24A-1v9sA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 6 PHE A  28
LEU A  15
LEU A  18
ARG A  19
 None
 0.95A 6e43A-1v9sA:
undetectable		 6e43A-1v9sA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 6 PHE A  28
LEU A  15
LEU A  18
ARG A  19
 None
 0.94A 6e43B-1v9sA:
undetectable		 6e43B-1v9sA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 6 PHE A  28
LEU A  15
LEU A  18
ARG A  19
 None
 0.97A 6e43C-1v9sA:
undetectable		 6e43C-1v9sA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 6 PHE A  28
LEU A  15
LEU A  18
ARG A  19
 None
 0.86A 6e43D-1v9sA:
undetectable		 6e43D-1v9sA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		3 / 3 VAL A  82
GLU A  85
ILE A 204
 None
 0.64A 6f7lB-1v9sA:
undetectable		 6f7lB-1v9sA:
18.85