SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 8 GLY A  93
LEU A 137
VAL A  44
PHE A  77
 None
 1.02A 1gsfC-1vaxA:
undetectable		 1gsfC-1vaxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 8 PHE A  82
ALA A  78
ARG A  79
LEU A  27
 None
 0.92A 2bxmA-1vaxA:
undetectable		 2bxmA-1vaxA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 7 PHE A 113
ARG A 127
GLN A 111
GLU A  24
 None
 0.99A 2c8aA-1vaxA:
undetectable		 2c8aA-1vaxA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		5 / 8 ARG A 107
GLY A 149
THR A 134
ALA A 135
ALA A 148
 None
 1.48A 2ej3C-1vaxA:
undetectable		 2ej3C-1vaxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 5 ARG A 285
ARG A 231
GLY A 230
GLU A 228
 None
 1.18A 3k9fA-1vaxA:
undetectable
3k9fB-1vaxA:
undetectable
3k9fC-1vaxA:
undetectable		 3k9fA-1vaxA:
20.36
3k9fB-1vaxA:
20.36
3k9fC-1vaxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 6 ARG A 285
ARG A 231
GLY A 230
GLU A 228
 None
 1.18A 3k9fA-1vaxA:
undetectable
3k9fB-1vaxA:
undetectable
3k9fD-1vaxA:
undetectable		 3k9fA-1vaxA:
20.36
3k9fB-1vaxA:
20.36
3k9fD-1vaxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 6 GLN A  47
PHE A  96
LEU A  92
PHE A  88
 None
 1.16A 5b1bC-1vaxA:
undetectable
5b1bJ-1vaxA:
undetectable		 5b1bC-1vaxA:
20.98
5b1bJ-1vaxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 7 ARG A 285
ARG A 231
GLY A 230
GLU A 228
 None
 0.95A 5btaA-1vaxA:
0.9
5btaC-1vaxA:
1.0
5btaD-1vaxA:
undetectable		 5btaA-1vaxA:
21.63
5btaC-1vaxA:
21.63
5btaD-1vaxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 6 ARG A 231
GLY A 230
GLU A 228
ARG A 285
 None
 0.93A 5btaA-1vaxA:
undetectable
5btaB-1vaxA:
undetectable
5btaC-1vaxA:
undetectable		 5btaA-1vaxA:
21.63
5btaB-1vaxA:
23.40
5btaC-1vaxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 6 ARG A 285
ARG A 231
GLY A 230
GLU A 228
 None
 0.99A 5btcA-1vaxA:
0.0
5btcC-1vaxA:
0.2
5btcD-1vaxA:
undetectable		 5btcA-1vaxA:
21.63
5btcC-1vaxA:
21.63
5btcD-1vaxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 6 ARG A 231
GLY A 230
GLU A 228
ARG A 285
 None
 1.02A 5btcA-1vaxA:
undetectable
5btcB-1vaxA:
undetectable
5btcC-1vaxA:
undetectable		 5btcA-1vaxA:
21.63
5btcB-1vaxA:
23.40
5btcC-1vaxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 7 ARG A 231
GLY A 230
GLU A 228
ARG A 285
 None
 0.91A 5btfA-1vaxA:
undetectable
5btfB-1vaxA:
undetectable
5btfC-1vaxA:
undetectable		 5btfA-1vaxA:
21.63
5btfB-1vaxA:
23.40
5btfC-1vaxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 7 ARG A 285
ARG A 231
GLY A 230
GLU A 228
 None
 0.92A 5btfA-1vaxA:
undetectable
5btfC-1vaxA:
undetectable
5btfD-1vaxA:
undetectable		 5btfA-1vaxA:
21.63
5btfC-1vaxA:
21.63
5btfD-1vaxA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 5 ARG A 231
GLY A 230
GLU A 228
ARG A 285
 None
 0.80A 5cdqA-1vaxA:
undetectable
5cdqB-1vaxA:
undetectable
5cdqC-1vaxA:
undetectable		 5cdqA-1vaxA:
21.07
5cdqB-1vaxA:
21.50
5cdqC-1vaxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 5 ARG A 231
GLY A 230
GLU A 228
ARG A 285
 None
 0.89A 5cdqR-1vaxA:
undetectable
5cdqS-1vaxA:
undetectable
5cdqT-1vaxA:
undetectable		 5cdqR-1vaxA:
21.07
5cdqS-1vaxA:
21.50
5cdqT-1vaxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		5 / 9 LEU A  89
ILE A 146
ARG A 189
GLU A  24
VAL A  25
 None
 1.27A 5igzA-1vaxA:
0.2		 5igzA-1vaxA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 6 ARG A 133
VAL A 206
TRP A 190
GLU A 239
 None
 1.29A 5unvA-1vaxA:
0.0
5unvB-1vaxA:
0.0		 5unvA-1vaxA:
22.12
5unvB-1vaxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 6 GLN A  47
PHE A  96
LEU A  92
PHE A  88
 None
 1.12A 5zcoP-1vaxA:
0.0
5zcoW-1vaxA:
0.2		 5zcoP-1vaxA:
20.98
5zcoW-1vaxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		4 / 6 GLN A  47
PHE A  96
LEU A  92
PHE A  88
 None
 1.11A 5zcpC-1vaxA:
0.2
5zcpJ-1vaxA:
undetectable		 5zcpC-1vaxA:
20.98
5zcpJ-1vaxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1vax URIC ACID OXIDASE
(Arthrobacter
globiformis) 		5 / 12 GLN A  40
VAL A  25
ALA A 135
ALA A 148
VAL A 147
 None
 1.05A 6c2mC-1vaxA:
undetectable		 6c2mC-1vaxA:
16.49