SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		3 / 3 ILE A  48
LEU A  51
VAL A  55
 None
 0.39A 1mz9B-1vb5A:
undetectable		 1mz9B-1vb5A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		6 / 11 GLY A 184
ALA A 217
ILE A 268
GLY A 261
PRO A 213
ILE A 182
 None
 1.48A 1n49C-1vb5A:
undetectable		 1n49C-1vb5A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		5 / 12 LEU A  33
ALA A  85
LEU A  89
MET A  92
ALA A  25
 None
 1.08A 1sa1A-1vb5A:
undetectable
1sa1B-1vb5A:
undetectable		 1sa1A-1vb5A:
19.60
1sa1B-1vb5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		5 / 12 LEU A  33
ALA A  85
LEU A  89
MET A  92
ALA A  25
 None
 1.09A 1sa1C-1vb5A:
3.5
1sa1D-1vb5A:
3.8		 1sa1C-1vb5A:
19.60
1sa1D-1vb5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		4 / 8 LEU A  51
ALA A  69
ILE A  72
GLY A  28
 None
 0.83A 1sv9A-1vb5A:
undetectable		 1sv9A-1vb5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		4 / 8 GLY A 184
ALA A 185
ASP A 186
PRO A 271
 None
 0.85A 4eyrB-1vb5A:
undetectable		 4eyrB-1vb5A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		4 / 8 ASP A 146
ASP A 186
GLU A 148
ASP A 252
 None
 1.11A 4gkhC-1vb5A:
undetectable
4gkhK-1vb5A:
2.2		 4gkhC-1vb5A:
22.19
4gkhK-1vb5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		5 / 7 LEU A 203
ILE A 263
GLY A 103
LEU A 106
ILE A 212
 None
 1.39A 5vkqA-1vb5A:
3.3
5vkqB-1vb5A:
3.3		 5vkqA-1vb5A:
10.47
5vkqB-1vb5A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		5 / 10 HIS A 208
ALA A 178
THR A 141
ILE A 139
ALA A 181
 None
 1.19A 5vyhA-1vb5A:
undetectable		 5vyhA-1vb5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B
(Pyrococcus
horikoshii) 		5 / 9 ILE A 126
ILE A 182
GLU A 157
VAL A 138
ILE A 113
 None
 1.30A 6hloA-1vb5A:
5.7		 6hloA-1vb5A:
19.73