SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vbj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		3 / 3 ASP A 119
TYR A  85
GLU A 125
 None
 0.77A 1vm1A-1vbjA:
undetectable		 1vm1A-1vbjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		3 / 3 LYS A  24
GLY A 266
PRO A 267
 None
 0.94A 2hreB-1vbjA:
undetectable		 2hreB-1vbjA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2INE_A_PACA317_0
(ALDOSE REDUCTASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 5 TRP A  23
TYR A  52
HIS A 110
TRP A 111
 CIT  A4001 ( 3.8A)
CIT  A4001 ( 4.2A)
CIT  A4001 ( 3.7A)
CIT  A4001 (-4.4A)
 0.20A 2ineA-1vbjA:
39.0		 2ineA-1vbjA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ISF_A_PACA317_0
(ALDOSE REDUCTASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 5 TRP A  23
TYR A  52
HIS A 110
TRP A 111
 CIT  A4001 ( 3.8A)
CIT  A4001 ( 4.2A)
CIT  A4001 ( 3.7A)
CIT  A4001 (-4.4A)
 0.18A 2isfA-1vbjA:
38.8		 2isfA-1vbjA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 7 TRP A  23
TYR A  52
HIS A 110
PHE A 272
 CIT  A4001 ( 3.8A)
CIT  A4001 ( 4.2A)
CIT  A4001 ( 3.7A)
CIT  A4001 ( 4.9A)
 1.46A 3s3gA-1vbjA:
39.0		 3s3gA-1vbjA:
38.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 7 TRP A  23
TYR A  52
HIS A 110
TRP A 111
 CIT  A4001 ( 3.8A)
CIT  A4001 ( 4.2A)
CIT  A4001 ( 3.7A)
CIT  A4001 (-4.4A)
 0.27A 3s3gA-1vbjA:
39.0		 3s3gA-1vbjA:
38.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		3 / 3 HIS A 263
SER A 188
GLU A 163
 None
NAP  A3001 (-3.0A)
None
 0.80A 3s8pA-1vbjA:
undetectable		 3s8pA-1vbjA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 TYR A  52
TRP A  79
HIS A 110
ASN A 140
SER A 188
 CIT  A4001 ( 4.2A)
None
CIT  A4001 ( 3.7A)
NAP  A3001 (-3.2A)
NAP  A3001 (-3.0A)
 0.33A 3ug8A-1vbjA:
39.0		 3ug8A-1vbjA:
38.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 7 TYR A  52
ASN A 140
GLU A 163
TYR A 265
 CIT  A4001 ( 4.2A)
NAP  A3001 (-3.2A)
None
None
 0.25A 3ugrA-1vbjA:
38.7		 3ugrA-1vbjA:
38.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 5 LEU A   7
MET A 158
PHE A  73
ASN A  11
 None
 1.46A 3uq6A-1vbjA:
3.2		 3uq6A-1vbjA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 8 TRP A  23
TRP A  79
HIS A 110
TRP A 111
 CIT  A4001 ( 3.8A)
None
CIT  A4001 ( 3.7A)
CIT  A4001 (-4.4A)
 0.27A 3v35A-1vbjA:
39.4		 3v35A-1vbjA:
38.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 8 THR A  48
LEU A 101
LEU A  99
GLY A  59
 None
 0.72A 4c9nA-1vbjA:
undetectable		 4c9nA-1vbjA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 8 ILE A 226
LEU A   7
ILE A 182
GLY A  12
 None
 0.84A 4hb8A-1vbjA:
undetectable		 4hb8A-1vbjA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 7 GLU A  32
THR A  35
THR A  76
LEU A 101
 None
 1.13A 4pfjA-1vbjA:
undetectable		 4pfjA-1vbjA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		5 / 11 HIS A  45
THR A  48
THR A  76
THR A  75
GLY A  59
 None
 1.25A 4qvlV-1vbjA:
undetectable
4qvlb-1vbjA:
undetectable		 4qvlV-1vbjA:
22.80
4qvlb-1vbjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		5 / 11 HIS A  45
THR A  48
THR A  76
THR A  75
GLY A  59
 None
 1.25A 4qvlH-1vbjA:
undetectable
4qvlN-1vbjA:
undetectable		 4qvlH-1vbjA:
22.80
4qvlN-1vbjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		5 / 11 HIS A  45
THR A  48
THR A  76
THR A  75
GLY A  59
 None
 1.24A 4qw1V-1vbjA:
undetectable
4qw1b-1vbjA:
undetectable		 4qw1V-1vbjA:
22.80
4qw1b-1vbjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		5 / 11 HIS A  45
THR A  48
THR A  76
THR A  75
GLY A  59
 None
 1.25A 4qw1H-1vbjA:
undetectable
4qw1N-1vbjA:
undetectable		 4qw1H-1vbjA:
22.80
4qw1N-1vbjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 PHE A  73
THR A 185
LEU A 108
LEU A   7
LEU A   9
 None
 1.39A 4qynB-1vbjA:
undetectable		 4qynB-1vbjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 7 GLY A  59
ALA A  58
GLU A  32
THR A  35
 None
 0.75A 4r1zB-1vbjA:
undetectable		 4r1zB-1vbjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 8 ALA A  31
ALA A  58
ALA A  38
ALA A  34
 None
 0.70A 4twdF-1vbjA:
undetectable
4twdG-1vbjA:
undetectable
4twdH-1vbjA:
undetectable
4twdI-1vbjA:
undetectable
4twdJ-1vbjA:
undetectable		 4twdF-1vbjA:
20.12
4twdG-1vbjA:
20.12
4twdH-1vbjA:
20.12
4twdI-1vbjA:
20.12
4twdJ-1vbjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 8 ALA A  38
ALA A  34
ALA A  31
ALA A  58
 None
 0.80A 4twdF-1vbjA:
undetectable
4twdG-1vbjA:
undetectable
4twdH-1vbjA:
undetectable
4twdI-1vbjA:
undetectable
4twdJ-1vbjA:
undetectable		 4twdF-1vbjA:
20.12
4twdG-1vbjA:
20.12
4twdH-1vbjA:
20.12
4twdI-1vbjA:
20.12
4twdJ-1vbjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 8 ALA A  38
ALA A  34
ALA A  31
ALA A  58
 None
 0.80A 4twdF-1vbjA:
undetectable
4twdG-1vbjA:
undetectable
4twdH-1vbjA:
undetectable
4twdI-1vbjA:
undetectable
4twdJ-1vbjA:
undetectable		 4twdF-1vbjA:
20.12
4twdG-1vbjA:
20.12
4twdH-1vbjA:
20.12
4twdI-1vbjA:
20.12
4twdJ-1vbjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 LEU A   3
THR A  35
ILE A  39
ILE A  46
THR A 227
 None
 1.02A 4x5jA-1vbjA:
undetectable		 4x5jA-1vbjA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		3 / 3 MET A  15
ASP A  47
PHE A  20
 None
NAP  A3001 (-3.6A)
None
 1.05A 4xeyB-1vbjA:
undetectable		 4xeyB-1vbjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 5 THR A  48
ALA A  49
THR A  76
TYR A 107
 None
 1.08A 5ecmA-1vbjA:
undetectable		 5ecmA-1vbjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 6 THR A  48
ALA A  49
THR A  76
TYR A 107
 None
 0.97A 5ecoA-1vbjA:
undetectable		 5ecoA-1vbjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 THR A  48
ALA A  49
ILE A 228
GLY A  21
LEU A 108
 None
None
NAP  A3001 (-4.4A)
NAP  A3001 (-3.1A)
None
 0.83A 5nfjA-1vbjA:
undetectable		 5nfjA-1vbjA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 GLU A  32
THR A  35
THR A  76
LEU A 101
 None
 1.33A 5v96A-1vbjA:
undetectable		 5v96A-1vbjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 GLU A  32
THR A  35
THR A  76
LEU A 101
 None
 1.33A 5v96B-1vbjA:
undetectable		 5v96B-1vbjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 4 GLU A  32
THR A  35
THR A  76
LEU A 101
 None
 1.34A 5v96D-1vbjA:
1.6		 5v96D-1vbjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		4 / 7 GLN A  83
GLY A 113
GLN A 170
TRP A 111
 None
None
None
CIT  A4001 (-4.4A)
 1.07A 5vlmC-1vbjA:
undetectable		 5vlmC-1vbjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1vbj PROSTAGLANDIN F
SYNTHASE
(Trypanosoma
brucei) 		5 / 12 THR A  75
VAL A 104
VAL A 133
PHE A 124
VAL A 138
 None
 1.36A 6iblA-1vbjA:
undetectable		 6iblA-1vbjA:
21.52