SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vbl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 9 PHE A 330
ILE A 341
ASP A 335
LEU A 361
PHE A 332
 None
 1.22A 1i00A-1vblA:
undetectable		 1i00A-1vblA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 11 LEU A 286
TYR A 301
ALA A 410
GLY A 411
PHE A 303
 None
 1.43A 1l5rA-1vblA:
undetectable		 1l5rA-1vblA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 TYR A  83
GLY A 149
GLY A 148
GLY A 147
PHE A 150
 None
 1.01A 1qzzA-1vblA:
undetectable		 1qzzA-1vblA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 10 LEU A 274
ASN A 277
LEU A   8
THR A 255
PHE A 248
 None
 1.18A 1zucA-1vblA:
undetectable		 1zucA-1vblA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 LEU A 274
ASN A 277
LEU A   8
THR A 255
PHE A 248
 None
 1.19A 1zucB-1vblA:
undetectable		 1zucB-1vblA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 8 LEU A  41
ILE A 145
ILE A 136
ILE A 163
 None
 0.84A 2bu8A-1vblA:
undetectable		 2bu8A-1vblA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 6 PRO A 224
HIS A 228
ASP A 190
ASP A 229
 None
None
CA  A 417 (-2.4A)
CA  A 417 (-3.5A)
 1.32A 2lh8A-1vblA:
0.0		 2lh8A-1vblA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 LEU A 274
ASN A 277
LEU A   8
THR A 255
PHE A 248
 None
 1.21A 2oaxB-1vblA:
undetectable		 2oaxB-1vblA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 LEU A 274
ASN A 277
LEU A   8
THR A 255
PHE A 248
 None
 1.22A 2oaxC-1vblA:
undetectable		 2oaxC-1vblA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 ILE A 152
ILE A  61
THR A 134
LEU A  45
PHE A 150
 None
 1.09A 2qo5A-1vblA:
undetectable		 2qo5A-1vblA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 7 VAL A  78
TYR A  83
ILE A 126
ASP A  68
 None
 1.22A 3bu1A-1vblA:
undetectable		 3bu1A-1vblA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		3 / 3 ASN A 250
HIS A 251
VAL A 254
 None
 0.83A 3elzB-1vblA:
undetectable		 3elzB-1vblA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 9 GLY A 148
GLN A 122
ASP A  68
ILE A  67
VAL A 128
 None
 1.02A 3fi0A-1vblA:
undetectable		 3fi0A-1vblA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 9 GLY A 148
GLN A 122
ASP A  68
ILE A  67
VAL A 128
 None
 0.98A 3fi0C-1vblA:
undetectable		 3fi0C-1vblA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 9 GLY A 148
GLN A 122
ASP A  68
ILE A  67
VAL A 128
 None
 1.03A 3fi0H-1vblA:
undetectable		 3fi0H-1vblA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 9 GLY A 148
GLN A 122
ASP A  68
ILE A  67
VAL A 128
 None
 0.99A 3fi0K-1vblA:
undetectable		 3fi0K-1vblA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 9 GLY A 148
GLN A 122
ASP A  68
ILE A  67
VAL A 128
 None
 1.03A 3fi0N-1vblA:
undetectable		 3fi0N-1vblA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 9 GLY A 148
GLN A 122
ASP A  68
ILE A  67
VAL A 128
 None
 1.08A 3fi0O-1vblA:
undetectable		 3fi0O-1vblA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 9 VAL A 272
ALA A  15
ILE A 159
PHE A 150
ILE A 243
 None
 1.26A 3hbbB-1vblA:
undetectable		 3hbbB-1vblA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 6 PRO A 177
GLY A 183
ASN A 186
GLU A 174
 None
 1.02A 3zqtA-1vblA:
undetectable		 3zqtA-1vblA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 6 ASP A 360
THR A 357
ILE A 368
PHE A 332
 None
 1.06A 4acbC-1vblA:
undetectable		 4acbC-1vblA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 5 GLY A 147
GLY A 148
MET A 127
GLU A 166
 None
 0.79A 4fglC-1vblA:
undetectable		 4fglC-1vblA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 6 GLY A 147
GLY A 148
MET A 127
GLU A 166
 None
 0.81A 4fglD-1vblA:
undetectable		 4fglD-1vblA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		3 / 3 LYS A 409
LEU A 405
ALA A 408
 None
 0.60A 4ikiA-1vblA:
undetectable		 4ikiA-1vblA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		3 / 3 ASP A 211
LEU A 169
VAL A  71
 None
 0.71A 4jecB-1vblA:
undetectable		 4jecB-1vblA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 10 ILE A 342
ALA A 372
ASP A 369
LEU A 361
ILE A 341
 None
 1.28A 4km0A-1vblA:
undetectable		 4km0A-1vblA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		3 / 3 ASP A 333
VAL A 359
ASN A 281
 None
 0.68A 4lmnA-1vblA:
undetectable		 4lmnA-1vblA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 LEU A  69
LEU A  41
ILE A 163
ALA A 143
ILE A 136
 None
 0.97A 4o2bD-1vblA:
undetectable		 4o2bD-1vblA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 11 GLY A 147
GLY A 148
MET A 127
ILE A 145
GLY A 210
 None
 1.16A 4qoiA-1vblA:
undetectable
4qoiB-1vblA:
undetectable		 4qoiA-1vblA:
21.39
4qoiB-1vblA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 4 GLY A  65
VAL A 139
PHE A  33
ILE A  61
 None
 1.12A 4xv2B-1vblA:
undetectable		 4xv2B-1vblA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 THR A  66
ALA A 410
SER A 191
ILE A 192
PHE A 150
 None
 1.33A 5iwuA-1vblA:
undetectable		 5iwuA-1vblA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 8 VAL A 128
ILE A  67
LEU A  69
ILE A 145
ILE A 163
 None
 0.96A 5numA-1vblA:
undetectable		 5numA-1vblA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 4 ARG A 161
ILE A 137
TYR A  62
ILE A  60
 None
 1.30A 5odhG-1vblA:
0.0		 5odhG-1vblA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 ALA A 167
PRO A 168
GLY A 147
ASP A 209
ASP A 308
 None
 1.13A 5wwsA-1vblA:
undetectable		 5wwsA-1vblA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 ALA A 167
PRO A 168
GLY A 147
ASP A 209
ASP A 308
 None
 1.13A 5wwsB-1vblA:
undetectable		 5wwsB-1vblA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		5 / 12 LEU A  69
LEU A  41
ILE A 163
ALA A 143
ILE A 136
 None
 1.01A 5xiwB-1vblA:
undetectable		 5xiwB-1vblA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 6 ASN A 299
TYR A 297
VAL A 294
THR A 273
 None
 1.39A 6f32B-1vblA:
undetectable		 6f32B-1vblA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 7 LEU A 256
ASP A 233
ASP A 190
ARG A 285
 None
CA  A 417 (-3.6A)
CA  A 417 (-2.4A)
None
 1.29A 6g31D-1vblA:
undetectable		 6g31D-1vblA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1vbl PECTATE LYASE 47
(Bacillus
sp.
TS-47) 		4 / 4 LEU A 256
ASP A 233
ASP A 190
ARG A 285
 None
CA  A 417 (-3.6A)
CA  A 417 (-2.4A)
None
 1.35A 6g31E-1vblA:
undetectable		 6g31E-1vblA:
12.03