SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		4 / 8 SER A 658
VAL A 659
LEU A 620
TYR A 668
 None
 0.93A 1fduB-1vbrA:
2.1		 1fduB-1vbrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		4 / 8 PHE A 796
LEU A 541
ALA A 551
PHE A 587
 None
 0.79A 2vcvF-1vbrA:
undetectable		 2vcvF-1vbrA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		4 / 8 PHE A 796
LEU A 541
ALA A 551
PHE A 587
 None
 0.77A 2vcvP-1vbrA:
undetectable		 2vcvP-1vbrA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		4 / 6 LEU A 833
PHE A 816
ASP A 798
LYS A 830
 None
 1.30A 2vn1B-1vbrA:
undetectable		 2vn1B-1vbrA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		4 / 6 ARG A 573
ILE A 610
TRP A 609
HIS A 627
 None
 1.26A 3deuA-1vbrA:
undetectable		 3deuA-1vbrA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		4 / 8 VAL A 639
VAL A 631
ILE A 686
GLY A 597
 None
 0.92A 3hjoA-1vbrA:
undetectable		 3hjoA-1vbrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		3 / 3 ASP A 689
ASN A 646
SER A 691
 None
XYP  A   2 (-3.4A)
None
 0.97A 3lslA-1vbrA:
undetectable
3lslD-1vbrA:
undetectable		 3lslA-1vbrA:
20.57
3lslD-1vbrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		3 / 3 SER A 691
ASP A 689
ASN A 646
 None
None
XYP  A   2 (-3.4A)
 1.00A 3lslA-1vbrA:
undetectable
3lslD-1vbrA:
undetectable		 3lslA-1vbrA:
20.57
3lslD-1vbrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		5 / 12 SER A 650
VAL A 649
ILE A 692
ASN A 696
HIS A 724
 None
 1.44A 4c49B-1vbrA:
undetectable		 4c49B-1vbrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		3 / 3 HIS A 596
GLY A 720
ILE A 686
 None
 0.54A 4k50A-1vbrA:
0.0		 4k50A-1vbrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		3 / 3 HIS A 596
GLY A 720
ILE A 686
 None
 0.52A 4k50I-1vbrA:
undetectable		 4k50I-1vbrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		3 / 3 ASP A 651
TRP A 802
SER A 691
 None
XYS  A   1 ( 4.0A)
None
 1.04A 4lrhB-1vbrA:
undetectable		 4lrhB-1vbrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		3 / 3 SER A 801
ASP A 798
GLN A 771
 None
 0.75A 4oltA-1vbrA:
undetectable
4oltB-1vbrA:
undetectable		 4oltA-1vbrA:
21.86
4oltB-1vbrA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		3 / 3 GLN A 771
SER A 801
ASP A 798
 None
 0.71A 4qwpA-1vbrA:
undetectable
4qwpB-1vbrA:
undetectable		 4qwpA-1vbrA:
22.39
4qwpB-1vbrA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		4 / 7 VAL A 601
TRP A 660
ILE A 664
TRP A 675
 None
 1.02A 4xo7B-1vbrA:
4.6		 4xo7B-1vbrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		5 / 12 LEU A 768
LEU A 760
GLY A 811
ALA A 813
LEU A 814
 None
 1.22A 5iktB-1vbrA:
1.1		 5iktB-1vbrA:
21.08