SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 321
ARG A 318
ILE A 269
 None
 0.84A 1a4gB-1vc2A:
undetectable		 1a4gB-1vc2A:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ASN A 311
TYR A 315
ASN A 152
TYR A 309
 NAD  A 336 (-3.8A)
NAD  A 336 (-3.5A)
None
None
 0.98A 1dssG-1vc2A:
49.0		 1dssG-1vc2A:
49.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 7 SER A 148
THR A 150
ASN A 152
TYR A 309
ASN A 311
TYR A 315
 None
None
None
None
NAD  A 336 (-3.8A)
NAD  A 336 (-3.5A)
 0.29A 1dssG-1vc2A:
49.0		 1dssG-1vc2A:
49.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ASN A 311
TYR A 315
ASN A 152
TYR A 309
 NAD  A 336 (-3.8A)
NAD  A 336 (-3.5A)
None
None
 0.97A 1dssR-1vc2A:
48.8		 1dssR-1vc2A:
49.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		7 / 8 SER A 148
THR A 150
ASN A 152
HIS A 176
TYR A 309
ASN A 311
TYR A 315
 None
None
None
None
None
NAD  A 336 (-3.8A)
NAD  A 336 (-3.5A)
 0.52A 1dssR-1vc2A:
48.8		 1dssR-1vc2A:
49.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 ARG A 247
ALA A 164
ALA A 257
GLU A 253
 None
 1.08A 1e7cA-1vc2A:
undetectable		 1e7cA-1vc2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 291
VAL A 160
GLY A 264
ALA A 262
LEU A 270
 None
 0.99A 1eqhA-1vc2A:
undetectable		 1eqhA-1vc2A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 THR A 150
LEU A 154
VAL A 157
LEU A 161
 None
 0.79A 1fbmD-1vc2A:
undetectable		 1fbmD-1vc2A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 THR A 150
LEU A 154
VAL A 157
LEU A 161
 None
 0.59A 1fbmE-1vc2A:
undetectable		 1fbmE-1vc2A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 VAL A  89
VAL A  91
SER A  93
ILE A  11
LEU A  19
 None
None
None
NAD  A 336 (-4.3A)
None
 1.32A 1igxA-1vc2A:
undetectable		 1igxA-1vc2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 VAL A 157
THR A 213
LEU A 217
VAL A 167
 None
 0.93A 1jgsA-1vc2A:
undetectable		 1jgsA-1vc2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ILE A  18
LEU A  19
VAL A  26
ALA A  85
 None
 0.90A 1mz9A-1vc2A:
undetectable		 1mz9A-1vc2A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 ILE A  18
LEU A  19
VAL A  26
ALA A  85
 None
 0.91A 1mz9C-1vc2A:
undetectable		 1mz9C-1vc2A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 LEU A 154
VAL A 157
LEU A 161
 None
 0.53A 1mz9B-1vc2A:
undetectable		 1mz9B-1vc2A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 VAL A 291
VAL A 160
ALA A 262
LEU A 270
 None
 0.85A 1pthA-1vc2A:
undetectable		 1pthA-1vc2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 VAL A 291
VAL A 160
ALA A 262
LEU A 270
 None
 0.86A 1pthB-1vc2A:
undetectable		 1pthB-1vc2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 SER A 289
SER A 153
THR A 150
SER A 239
VAL A 167
 None
 1.22A 2nniA-1vc2A:
undetectable		 2nniA-1vc2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 TRP A 308
TYR A 309
ILE A 282
SER A 177
 None
 1.30A 2xz5A-1vc2A:
undetectable
2xz5B-1vc2A:
undetectable		 2xz5A-1vc2A:
21.92
2xz5B-1vc2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ILE A 115
LEU A 144
TYR A 315
LEU A 129
 None
None
NAD  A 336 (-3.5A)
None
 0.91A 3ablN-1vc2A:
undetectable
3ablW-1vc2A:
undetectable		 3ablN-1vc2A:
20.31
3ablW-1vc2A:
10.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ASN A 311
TYR A 315
ASN A 152
TYR A 309
 NAD  A 336 (-3.8A)
NAD  A 336 (-3.5A)
None
None
 1.00A 3dmtC-1vc2A:
27.8		 3dmtC-1vc2A:
46.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		7 / 8 SER A 148
THR A 150
ASN A 152
HIS A 176
TYR A 309
ASN A 311
TYR A 315
 None
None
None
None
None
NAD  A 336 (-3.8A)
NAD  A 336 (-3.5A)
 0.43A 3dmtC-1vc2A:
27.8		 3dmtC-1vc2A:
46.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 291
VAL A 160
GLY A 264
ALA A 262
LEU A 270
 None
 0.98A 3pghC-1vc2A:
undetectable		 3pghC-1vc2A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ALA A 251
VAL A 254
LEU A 258
LEU A 295
 None
 0.43A 3roxA-1vc2A:
3.6		 3roxA-1vc2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 291
VAL A 160
GLY A 264
ALA A 262
LEU A 270
 None
 1.01A 3rr3A-1vc2A:
undetectable		 3rr3A-1vc2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 291
VAL A 160
GLY A 264
ALA A 262
LEU A 270
 None
 1.02A 3rr3B-1vc2A:
undetectable		 3rr3B-1vc2A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PRO A  77
ILE A  80
SER A 145
VAL A 319
ASN A   6
 None
None
None
None
NAD  A 336 ( 3.9A)
 1.21A 3v8vA-1vc2A:
4.1		 3v8vA-1vc2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 161
VAL A 157
ARG A 247
THR A 296
GLU A 253
 None
 1.28A 4fiaA-1vc2A:
undetectable		 4fiaA-1vc2A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 161
VAL A 157
ARG A 247
THR A 296
GLU A 253
 None
 1.28A 4fiaA-1vc2A:
undetectable		 4fiaA-1vc2A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 258
TYR A 272
VAL A 160
LEU A 295
 None
 0.97A 4l1xA-1vc2A:
undetectable		 4l1xA-1vc2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 VAL A 291
VAL A 160
GLY A 264
ALA A 262
LEU A 270
 None
 0.96A 4ph9A-1vc2A:
undetectable		 4ph9A-1vc2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 VAL A 291
VAL A 160
GLY A 264
ALA A 262
LEU A 270
 None
 0.96A 4ph9B-1vc2A:
undetectable		 4ph9B-1vc2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 325
LEU A 144
VAL A 331
HIS A 142
 None
 0.99A 4qknA-1vc2A:
0.0		 4qknA-1vc2A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 SER A 145
THR A 150
THR A 151
ALA A 118
THR A  98
 None
None
None
NAD  A 336 (-3.5A)
None
 1.45A 5bxnV-1vc2A:
undetectable
5bxnb-1vc2A:
undetectable		 5bxnV-1vc2A:
21.99
5bxnb-1vc2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 SER A 145
THR A 150
THR A 151
ALA A 118
THR A  98
 None
None
None
NAD  A 336 (-3.5A)
None
 1.46A 5bxnH-1vc2A:
undetectable
5bxnN-1vc2A:
undetectable		 5bxnH-1vc2A:
21.99
5bxnN-1vc2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 THR A 151
ALA A 147
ASN A 152
 None
 0.58A 5ersA-1vc2A:
2.1		 5ersA-1vc2A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ALA A 257
VAL A 254
ILE A 241
VAL A 167
ALA A 164
 None
 1.18A 5nukA-1vc2A:
undetectable		 5nukA-1vc2A:
18.14