SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		6 / 12 ALA A 232
ASP A 231
VAL A 177
GLY A 179
ILE A 180
ILE A  49
 None
 1.12A 1hshA-1vc4A:
undetectable		 1hshA-1vc4A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		4 / 4 GLY A 216
SER A 238
VAL A 233
LEU A 192
 SO4  A2001 (-3.8A)
None
None
None
 1.10A 1yajB-1vc4A:
undetectable		 1yajB-1vc4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 PHE A 230
LEU A 211
LEU A 178
GLU A 164
LEU A 167
 None
 1.23A 2bxfA-1vc4A:
undetectable		 2bxfA-1vc4A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 LEU A  28
LEU A  98
PHE A 119
 None
 0.60A 2pgrA-1vc4A:
5.5		 2pgrA-1vc4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		4 / 7 LEU A 133
ASP A 113
ILE A  15
GLU A 160
 None
 1.07A 2qqdA-1vc4A:
undetectable
2qqdE-1vc4A:
undetectable		 2qqdA-1vc4A:
13.45
2qqdE-1vc4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 232
ASP A 231
VAL A 177
GLY A 179
ILE A  49
 None
 0.86A 2rkgA-1vc4A:
undetectable		 2rkgA-1vc4A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 232
ASP A 231
VAL A 177
GLY A 179
ILE A  49
 None
 0.87A 2rkgB-1vc4A:
undetectable		 2rkgB-1vc4A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 8 LEU A 110
LEU A 133
ALA A 124
LEU A 121
ALA A 150
 None
 1.30A 2vcvF-1vc4A:
undetectable		 2vcvF-1vc4A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 11 LEU A 133
GLU A 160
LEU A 138
GLY A 144
LEU A 147
 None
 1.40A 3hm1B-1vc4A:
undetectable		 3hm1B-1vc4A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 234
GLU A 214
ASN A 181
SER A  83
 None
 1.39A 3i9jB-1vc4A:
undetectable		 3i9jB-1vc4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		4 / 5 VAL A 177
LEU A 158
ILE A  49
ALA A 232
 None
 0.91A 3n8yB-1vc4A:
undetectable		 3n8yB-1vc4A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 11 GLU A 160
ASN A 182
SER A 215
LEU A 158
LEU A 133
 None
None
SO4  A2001 (-3.5A)
None
None
 1.37A 3ndvA-1vc4A:
undetectable
3ndvB-1vc4A:
undetectable		 3ndvA-1vc4A:
23.85
3ndvB-1vc4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 11 LEU A 158
LEU A 133
GLU A 160
ASN A 182
SER A 215
 None
None
None
None
SO4  A2001 (-3.5A)
 1.37A 3ndvC-1vc4A:
undetectable
3ndvD-1vc4A:
undetectable		 3ndvC-1vc4A:
23.85
3ndvD-1vc4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 175
GLY A 179
ILE A 180
ASP A 184
LEU A 185
 None
 0.90A 3o7wA-1vc4A:
undetectable		 3o7wA-1vc4A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 232
ASP A 231
VAL A 177
GLY A 179
ILE A  49
 None
 0.83A 3s54B-1vc4A:
undetectable		 3s54B-1vc4A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		4 / 7 VAL A 177
ARG A  80
ILE A  49
ALA A  81
 None
SO4  A2002 (-3.8A)
None
None
 0.66A 4lv9A-1vc4A:
3.3		 4lv9A-1vc4A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		4 / 7 VAL A 177
ARG A  80
ILE A  49
ALA A  81
 None
SO4  A2002 (-3.8A)
None
None
 0.65A 4lv9B-1vc4A:
3.2		 4lv9B-1vc4A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A 178
GLY A 174
ALA A 173
ILE A 169
THR A 143
 None
 1.03A 4xdrA-1vc4A:
undetectable		 4xdrA-1vc4A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A 174
ALA A 175
ARG A 205
GLU A 172
GLU A 168
 None
 1.04A 4xt8A-1vc4A:
undetectable		 4xt8A-1vc4A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 173
LEU A 171
ALA A 175
LEU A 178
ALA A 145
 None
 0.85A 5jglA-1vc4A:
undetectable		 5jglA-1vc4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 232
ASP A 231
VAL A 177
GLY A 179
ILE A  49
 None
 0.87A 5t8hA-1vc4A:
undetectable		 5t8hA-1vc4A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Thermus
thermophilus) 		4 / 5 ILE A 135
PHE A 114
ARG A 183
THR A 187
 None
 1.17A 5z84N-1vc4A:
0.0
5z84W-1vc4A:
undetectable		 5z84N-1vc4A:
19.76
5z84W-1vc4A:
13.41