SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vcg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 ALA A 274
THR A  26
THR A 243
ILE A 247
GLY A 216
 None
None
None
None
FMN  A 501 ( 4.0A)
 1.16A 1c9sN-1vcgA:
undetectable
1c9sO-1vcgA:
undetectable		 1c9sN-1vcgA:
10.77
1c9sO-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 9 ALA A 274
THR A  26
THR A 243
ILE A 247
GLY A 216
 None
None
None
None
FMN  A 501 ( 4.0A)
 1.15A 1c9sQ-1vcgA:
undetectable
1c9sR-1vcgA:
undetectable		 1c9sQ-1vcgA:
10.77
1c9sR-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.17A 1c9sL-1vcgA:
undetectable
1c9sV-1vcgA:
undetectable		 1c9sL-1vcgA:
10.77
1c9sV-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 9 LEU A 277
ILE A 247
VAL A 265
GLY A 263
ALA A 261
 None
None
None
FMN  A 501 (-3.2A)
None
 1.28A 1e7aA-1vcgA:
undetectable		 1e7aA-1vcgA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 ALA A 246
GLY A 190
GLY A 213
LEU A 126
LEU A 206
 None
FMN  A 501 (-3.8A)
None
None
None
 0.97A 1eizA-1vcgA:
undetectable		 1eizA-1vcgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 ALA A 246
GLY A 190
GLY A 213
LEU A 126
LEU A 206
 None
FMN  A 501 (-3.8A)
None
None
None
 0.97A 1ej0A-1vcgA:
undetectable		 1ej0A-1vcgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		4 / 7 LEU A 129
PHE A 151
VAL A 153
VAL A 186
 None
 0.90A 1epbA-1vcgA:
undetectable		 1epbA-1vcgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		4 / 5 HIS A 233
GLU A 224
ALA A 159
HIS A 191
 None
 1.42A 1errA-1vcgA:
0.0
1errB-1vcgA:
0.0		 1errA-1vcgA:
22.22
1errB-1vcgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 9 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.12A 1gtfD-1vcgA:
undetectable
1gtfE-1vcgA:
undetectable		 1gtfD-1vcgA:
10.77
1gtfE-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.11A 1gtfJ-1vcgA:
undetectable
1gtfK-1vcgA:
undetectable		 1gtfJ-1vcgA:
10.77
1gtfK-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 9 ALA A 274
THR A  26
THR A 243
ILE A 247
GLY A 216
 None
None
None
None
FMN  A 501 ( 4.0A)
 1.18A 1gtfR-1vcgA:
undetectable
1gtfS-1vcgA:
undetectable		 1gtfR-1vcgA:
10.77
1gtfS-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 ALA A 279
LEU A 282
PRO A  60
ALA A 261
GLY A 263
 None
None
None
None
FMN  A 501 (-3.2A)
 1.31A 1mjqG-1vcgA:
undetectable
1mjqH-1vcgA:
undetectable		 1mjqG-1vcgA:
16.33
1mjqH-1vcgA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A  48
THR A  49
LEU A 281
LEU A 282
ILE A 303
 None
 0.92A 1qknA-1vcgA:
undetectable		 1qknA-1vcgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 8 ASP A 210
ALA A 212
GLY A 216
GLY A 264
ALA A  65
 None
FMN  A 501 ( 3.8A)
FMN  A 501 ( 4.0A)
FMN  A 501 (-4.3A)
FMN  A 501 (-3.3A)
 1.13A 1sguA-1vcgA:
undetectable		 1sguA-1vcgA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		4 / 7 LEU A 120
GLU A 145
LEU A  78
ALA A  81
 None
 1.06A 1sn0B-1vcgA:
undetectable
1sn0D-1vcgA:
undetectable		 1sn0B-1vcgA:
19.09
1sn0D-1vcgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 9 LEU A 307
VAL A 284
ALA A 285
LEU A  80
MET A  91
 None
FMN  A 501 ( 4.2A)
FMN  A 501 (-2.9A)
None
None
 1.27A 1tbfA-1vcgA:
undetectable		 1tbfA-1vcgA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 ALA A 274
THR A  26
THR A 243
ILE A 247
GLY A 216
 None
None
None
None
FMN  A 501 ( 4.0A)
 1.10A 1utdE-1vcgA:
undetectable
1utdF-1vcgA:
undetectable		 1utdE-1vcgA:
10.77
1utdF-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 ALA A 274
THR A  26
THR A 243
ILE A 247
GLY A 216
 None
None
None
None
FMN  A 501 ( 4.0A)
 1.10A 1utdH-1vcgA:
undetectable
1utdI-1vcgA:
undetectable		 1utdH-1vcgA:
10.77
1utdI-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 ALA A 274
THR A  26
THR A 243
ILE A 247
GLY A 216
 None
None
None
None
FMN  A 501 ( 4.0A)
 1.16A 1utdU-1vcgA:
undetectable
1utdV-1vcgA:
undetectable		 1utdU-1vcgA:
10.77
1utdV-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 ASP A 210
ALA A 212
GLY A 216
GLY A 264
VAL A 265
 None
FMN  A 501 ( 3.8A)
FMN  A 501 ( 4.0A)
FMN  A 501 (-4.3A)
None
 0.89A 2avsA-1vcgA:
undetectable		 2avsA-1vcgA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A  57
LEU A 282
LEU A 281
GLY A 271
LEU A 310
 None
 1.00A 2ouzA-1vcgA:
undetectable		 2ouzA-1vcgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 177
LEU A 174
LEU A 170
GLY A 133
LEU A 137
 None
 0.89A 2ouzA-1vcgA:
undetectable		 2ouzA-1vcgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		4 / 4 LEU A 282
ARG A 311
LEU A 314
ALA A  59
 None
 0.95A 3b9mA-1vcgA:
undetectable		 3b9mA-1vcgA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 268
ALA A 276
ALA A 325
LEU A 307
LEU A 314
 None
 1.09A 3mteA-1vcgA:
undetectable		 3mteA-1vcgA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 268
ALA A 276
ALA A 325
LEU A 307
LEU A 314
 None
 1.06A 3mteB-1vcgA:
undetectable		 3mteB-1vcgA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		6 / 12 VAL A 329
LEU A  33
LEU A 310
GLY A 271
ALA A 274
LEU A 277
 None
 1.45A 3n8zB-1vcgA:
undetectable		 3n8zB-1vcgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 268
ALA A 276
ALA A 325
LEU A 307
LEU A 314
 None
 1.04A 3p2kA-1vcgA:
undetectable		 3p2kA-1vcgA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A  33
GLY A 327
ALA A 319
LEU A 314
LEU A 277
 None
 1.15A 3p5nA-1vcgA:
undetectable		 3p5nA-1vcgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A  33
GLY A 327
ALA A 325
LEU A 314
LEU A 277
 None
 1.11A 3p5nA-1vcgA:
undetectable		 3p5nA-1vcgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A  33
GLY A 327
ALA A 319
LEU A 314
LEU A 277
 None
 1.15A 3p5nB-1vcgA:
undetectable		 3p5nB-1vcgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A  33
GLY A 327
ALA A 325
LEU A 314
LEU A 277
 None
 1.11A 3p5nB-1vcgA:
undetectable		 3p5nB-1vcgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		4 / 5 LEU A 281
ILE A 121
ALA A 208
MET A  92
 None
 0.83A 4dc3B-1vcgA:
undetectable		 4dc3B-1vcgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		4 / 7 LEU A 140
ALA A 146
ASP A 147
ILE A  63
 None
 0.91A 4eyrA-1vcgA:
undetectable		 4eyrA-1vcgA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 GLU A  74
LEU A  80
LEU A  99
ALA A 285
LEU A  11
 None
None
None
FMN  A 501 (-2.9A)
None
 1.23A 4retC-1vcgA:
undetectable		 4retC-1vcgA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 138
LEU A 204
VAL A 184
VAL A 186
LEU A 126
 None
 1.10A 4y0qA-1vcgA:
undetectable		 4y0qA-1vcgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 204
VAL A 184
VAL A 186
LEU A 126
PHE A 151
 None
 0.92A 4y0qA-1vcgA:
undetectable		 4y0qA-1vcgA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A 204
VAL A 184
VAL A 186
LEU A 126
PHE A 151
 None
 0.92A 4y0sA-1vcgA:
undetectable		 4y0sA-1vcgA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 PRO A 242
GLY A 264
GLY A 215
GLY A  27
LEU A  28
 None
FMN  A 501 (-4.3A)
None
None
None
 0.81A 5c0oE-1vcgA:
undetectable		 5c0oE-1vcgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		6 / 12 THR A  26
GLY A 190
GLY A 263
GLY A 264
GLU A 188
HIS A 191
 None
FMN  A 501 (-3.8A)
FMN  A 501 (-3.2A)
FMN  A 501 (-4.3A)
None
None
 1.33A 5c0oF-1vcgA:
undetectable		 5c0oF-1vcgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 PRO A 242
GLY A 264
GLY A 215
GLY A  27
LEU A  28
 None
FMN  A 501 (-4.3A)
None
None
None
 0.88A 5c0oG-1vcgA:
undetectable		 5c0oG-1vcgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 12 ALA A 246
PRO A 242
GLY A 190
GLY A 192
GLY A 240
 None
None
FMN  A 501 (-3.8A)
None
None
 0.94A 5c0oH-1vcgA:
undetectable		 5c0oH-1vcgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.09A 5eevA-1vcgA:
undetectable
5eevB-1vcgA:
undetectable		 5eevA-1vcgA:
10.77
5eevB-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.09A 5eewA-1vcgA:
undetectable
5eewB-1vcgA:
undetectable		 5eewA-1vcgA:
10.77
5eewB-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.09A 5eexA-1vcgA:
undetectable
5eexB-1vcgA:
undetectable		 5eexA-1vcgA:
10.77
5eexB-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.09A 5eeyA-1vcgA:
undetectable
5eeyB-1vcgA:
undetectable		 5eeyA-1vcgA:
10.77
5eeyB-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.09A 5eezA-1vcgA:
undetectable
5eezB-1vcgA:
undetectable		 5eezA-1vcgA:
10.77
5eezB-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.09A 5ef0A-1vcgA:
undetectable
5ef0B-1vcgA:
undetectable		 5ef0A-1vcgA:
10.77
5ef0B-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.09A 5ef1A-1vcgA:
undetectable
5ef1B-1vcgA:
undetectable		 5ef1A-1vcgA:
10.77
5ef1B-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.09A 5ef2A-1vcgA:
undetectable
5ef2B-1vcgA:
undetectable		 5ef2A-1vcgA:
10.77
5ef2B-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 GLY A 216
ALA A 274
THR A  26
THR A 243
ILE A 247
 FMN  A 501 ( 4.0A)
None
None
None
None
 1.09A 5ef3A-1vcgA:
undetectable
5ef3B-1vcgA:
undetectable		 5ef3A-1vcgA:
10.77
5ef3B-1vcgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		3 / 3 ILE A 247
MET A 185
ASP A 280
 None
 0.76A 5h2uA-1vcgA:
undetectable		 5h2uA-1vcgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		6 / 12 GLY A 271
LEU A 314
THR A 267
VAL A 265
ALA A 276
ALA A 244
 None
 1.34A 5kpcA-1vcgA:
undetectable		 5kpcA-1vcgA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		5 / 10 LEU A 254
GLU A 249
VAL A 211
LEU A 193
ALA A 198
 None
 1.20A 5o96E-1vcgA:
3.1
5o96F-1vcgA:
2.7		 5o96E-1vcgA:
21.31
5o96F-1vcgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Thermus
thermophilus) 		4 / 8 THR A 217
GLY A 216
GLY A 264
SER A 262
 FMN  A 501 (-3.7A)
FMN  A 501 ( 4.0A)
FMN  A 501 (-4.3A)
FMN  A 501 ( 3.8A)
 0.71A 5vw9A-1vcgA:
undetectable		 5vw9A-1vcgA:
21.58