SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 175
LEU A  17
VAL A  15
PHE A  37
LEU A  66
 None
 1.24A 3b0wA-1vchA:
undetectable		 3b0wA-1vchA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A  45
ALA A  41
LEU A  70
THR A  38
 None
 1.04A 3cfqA-1vchA:
undetectable
3cfqB-1vchA:
undetectable		 3cfqA-1vchA:
21.14
3cfqB-1vchA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A  45
ALA A  41
LEU A  70
THR A  38
 None
 1.07A 4ikiB-1vchA:
undetectable		 4ikiB-1vchA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A  45
ALA A  41
LEU A  70
THR A  38
 None
 1.05A 4ikjA-1vchA:
undetectable
4ikjB-1vchA:
undetectable		 4ikjA-1vchA:
21.14
4ikjB-1vchA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A  45
ALA A  41
LEU A  70
THR A  38
 None
 1.00A 4ikkA-1vchA:
undetectable
4ikkB-1vchA:
undetectable		 4ikkA-1vchA:
21.14
4ikkB-1vchA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A  68
VAL A  49
LEU A  56
 None
 0.74A 4m2vA-1vchA:
undetectable		 4m2vA-1vchA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN
(Thermus
thermophilus) 		3 / 3 ASP A 128
VAL A 126
LEU A  45
 None
 0.58A 5e5jB-1vchA:
undetectable		 5e5jB-1vchA:
19.54