SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vcn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 11 SER A 491
VAL A 490
LEU A 394
HIS A 471
GLU A 474
 None
 1.42A 1iolA-1vcnA:
3.4		 1iolA-1vcnA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 6 ARG A 137
ILE A 132
PHE A 171
GLU A 166
 None
 1.26A 1nsiA-1vcnA:
undetectable
1nsiB-1vcnA:
undetectable		 1nsiA-1vcnA:
21.91
1nsiB-1vcnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 6 ARG A 137
ILE A 132
PHE A 171
GLU A 166
 None
 1.28A 1nsiC-1vcnA:
0.2
1nsiD-1vcnA:
0.0		 1nsiC-1vcnA:
21.91
1nsiD-1vcnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 4 ALA A 402
VAL A 405
ALA A 406
HIS A 422
 None
 1.24A 1q23K-1vcnA:
undetectable		 1q23K-1vcnA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 517
LEU A 388
LEU A 459
ILE A 450
LEU A 394
 None
 1.20A 1tw4B-1vcnA:
0.0		 1tw4B-1vcnA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		3 / 3 GLN A 395
HIS A 471
ARG A 472
 None
 1.04A 1zlqA-1vcnA:
undetectable		 1zlqA-1vcnA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 11 GLY A 393
GLY A 363
GLN A 395
GLN A 520
ILE A 508
 None
 1.39A 2dr2A-1vcnA:
2.4		 2dr2A-1vcnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 7 THR A 420
ASP A 417
VAL A 374
LEU A 483
 None
 1.04A 2hdnE-1vcnA:
undetectable
2hdnF-1vcnA:
3.1
2hdnH-1vcnA:
3.6		 2hdnE-1vcnA:
6.20
2hdnF-1vcnA:
22.22
2hdnH-1vcnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 7 VAL A 374
LEU A 483
THR A 420
ASP A 417
 None
 1.04A 2hdnF-1vcnA:
3.1
2hdnG-1vcnA:
undetectable
2hdnH-1vcnA:
3.6		 2hdnF-1vcnA:
22.22
2hdnG-1vcnA:
6.20
2hdnH-1vcnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 4 LEU A 262
PRO A 259
LEU A  37
ARG A 269
 None
 1.43A 2qd2A-1vcnA:
2.7		 2qd2A-1vcnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 8 PRO A 523
SER A 521
ALA A 507
PRO A 535
 None
 0.92A 2v32A-1vcnA:
undetectable
2v32B-1vcnA:
undetectable		 2v32A-1vcnA:
18.05
2v32B-1vcnA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 8 PRO A 535
PRO A 523
SER A 521
ALA A 507
 None
 0.91A 2v32A-1vcnA:
undetectable
2v32B-1vcnA:
undetectable		 2v32A-1vcnA:
18.05
2v32B-1vcnA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 8 PRO A 523
SER A 521
ALA A 507
PRO A 535
 None
 0.89A 2v41G-1vcnA:
undetectable
2v41H-1vcnA:
undetectable		 2v41G-1vcnA:
18.05
2v41H-1vcnA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		3 / 3 PRO A 362
GLY A 307
TYR A 316
 None
 0.69A 2vouB-1vcnA:
undetectable		 2vouB-1vcnA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		3 / 3 PRO A 362
GLY A 307
TYR A 316
 None
 0.68A 2vouC-1vcnA:
undetectable		 2vouC-1vcnA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 12 VAL A 150
ALA A  47
ILE A  82
ILE A  50
THR A  46
 None
 1.02A 2w3vA-1vcnA:
4.5		 2w3vA-1vcnA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 4 GLY A 153
GLU A 151
ASP A  79
TYR A  53
 SO4  A 610 (-3.0A)
SO4  A 610 (-4.4A)
SO4  A 610 ( 4.7A)
None
 1.47A 2yvlC-1vcnA:
1.6		 2yvlC-1vcnA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 9 ALA A 411
SER A 413
LEU A 392
VAL A 361
ILE A 370
 None
 1.26A 3claA-1vcnA:
undetectable		 3claA-1vcnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 10 VAL A 150
ALA A  47
ILE A  82
ILE A  50
THR A  46
 None
 1.07A 3clbD-1vcnA:
4.2		 3clbD-1vcnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 11 VAL A 150
ALA A  47
ILE A  82
ILE A  50
THR A  46
 None
 1.06A 3hbbC-1vcnA:
3.5		 3hbbC-1vcnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 10 VAL A 150
ALA A  47
ILE A  82
ILE A  50
THR A  46
 None
 1.08A 3hbbD-1vcnA:
undetectable		 3hbbD-1vcnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 12 TYR A 182
LEU A 209
VAL A 152
GLY A 153
ILE A 132
 None
None
None
SO4  A 610 (-3.0A)
None
 1.10A 3ijdB-1vcnA:
undetectable		 3ijdB-1vcnA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 12 VAL A 150
ALA A  47
ILE A  82
ILE A  50
THR A  46
 None
 1.10A 3qfxA-1vcnA:
3.9		 3qfxA-1vcnA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 12 VAL A 150
ALA A  47
ILE A  82
ILE A  50
THR A  46
 None
 1.11A 3qfxB-1vcnA:
undetectable		 3qfxB-1vcnA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		3 / 3 LYS A 198
LYS A 200
PRO A 201
 SO4  A 630 (-2.9A)
SO4  A 630 (-4.0A)
None
 1.18A 4dv1L-1vcnA:
undetectable		 4dv1L-1vcnA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 6 ARG A 468
ASP A  92
ASP A  90
ARG A 528
 None
 1.38A 4kcnB-1vcnA:
undetectable		 4kcnB-1vcnA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 11 GLY A 363
GLY A 364
LEU A 392
HIS A 471
HIS A 522
 None
 0.51A 4l8fB-1vcnA:
18.7		 4l8fB-1vcnA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 11 GLY A 363
GLY A 364
LEU A 392
HIS A 471
HIS A 522
 None
 0.53A 4l8fD-1vcnA:
18.7		 4l8fD-1vcnA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 9 VAL A 220
LEU A 219
LEU A 267
GLY A  19
LEU A  30
 None
 1.03A 4rs0A-1vcnA:
undetectable		 4rs0A-1vcnA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 12 THR A 454
SER A 491
GLY A 461
GLY A 538
LEU A 517
 None
 1.11A 4uinH-1vcnA:
undetectable
4uinL-1vcnA:
undetectable		 4uinH-1vcnA:
17.74
4uinL-1vcnA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		6 / 12 ALA A 380
GLN A 378
ARG A 403
ILE A 396
LEU A 360
ILE A 370
 None
 1.47A 4uw0A-1vcnA:
undetectable		 4uw0A-1vcnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		3 / 3 VAL A 540
LEU A 544
VAL A 301
 None
 0.58A 4wq4A-1vcnA:
undetectable		 4wq4A-1vcnA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		4 / 8 TYR A 387
GLY A 389
TYR A 473
GLY A 363
 None
 0.87A 5albL-1vcnA:
undetectable		 5albL-1vcnA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LYS A 254
ALA A 326
SER A 527
ILE A 328
PRO A 529
 None
 1.39A 5mlmA-1vcnA:
3.3		 5mlmA-1vcnA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		3 / 3 GLU A 131
HIS A 127
VAL A 108
 None
 0.63A 5trqB-1vcnA:
0.0		 5trqB-1vcnA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		3 / 3 MET A 497
ASP A 445
ARG A  95
 None
 1.21A 5z6jA-1vcnA:
4.1		 5z6jA-1vcnA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		3 / 3 TYR A 460
ALA A 492
LEU A 519
 None
 0.69A 6d9kF-1vcnA:
4.5		 6d9kF-1vcnA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 1vcn CTP SYNTHETASE
(Thermus
thermophilus) 		5 / 12 LEU A 267
THR A 186
ALA A 274
ASP A 217
LEU A 181
 None
 1.32A 6ie8A-1vcnA:
0.0		 6ie8A-1vcnA:
16.64