SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vcv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 11 GLU A  82
ALA A 111
GLY A 112
ARG A 216
PHE A 144
 None
 1.44A 1l5rA-1vcvA:
undetectable		 1l5rA-1vcvA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		4 / 4 ILE A 137
LEU A 104
VAL A 107
ALA A  71
 None
 0.99A 1mz9A-1vcvA:
undetectable		 1mz9A-1vcvA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 12 ALA A  87
LEU A 104
VAL A 108
LEU A 185
ILE A 174
 None
 0.91A 1s9pA-1vcvA:
undetectable		 1s9pA-1vcvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 8 ALA A 142
GLY A 109
ILE A 105
PRO A  88
ALA A  87
 None
 1.19A 1sguA-1vcvA:
undetectable		 1sguA-1vcvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 12 GLU A 122
VAL A 187
MET A 189
ARG A 170
ALA A 171
 None
 1.16A 2jj8B-1vcvA:
0.3		 2jj8B-1vcvA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 11 ALA A 142
VAL A  85
ILE A 105
PRO A  88
VAL A 118
 None
 0.95A 2nnpB-1vcvA:
undetectable		 2nnpB-1vcvA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 10 TYR A 134
ILE A 145
TYR A 183
LEU A 104
VAL A 100
 None
 1.14A 2w98A-1vcvA:
undetectable		 2w98A-1vcvA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 12 ARG A 126
SER A 148
ILE A 137
ARG A  95
LEU A 133
 None
 1.37A 3iv6C-1vcvA:
undetectable		 3iv6C-1vcvA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 11 THR A 120
GLU A 122
LEU A 125
ASN A 162
LEU A 133
 None
 1.23A 3ndvA-1vcvA:
undetectable
3ndvB-1vcvA:
undetectable		 3ndvA-1vcvA:
22.04
3ndvB-1vcvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 11 LEU A 133
THR A 120
GLU A 122
LEU A 125
ASN A 162
 None
 1.23A 3ndvA-1vcvA:
undetectable
3ndvB-1vcvA:
undetectable		 3ndvA-1vcvA:
22.04
3ndvB-1vcvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 11 THR A 120
GLU A 122
LEU A 125
ASN A 162
LEU A 133
 None
 1.23A 3ndvC-1vcvA:
undetectable
3ndvD-1vcvA:
undetectable		 3ndvC-1vcvA:
22.04
3ndvD-1vcvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 11 LEU A 133
THR A 120
GLU A 122
LEU A 125
ASN A 162
 None
 1.25A 3ndvC-1vcvA:
0.0
3ndvD-1vcvA:
0.0		 3ndvC-1vcvA:
22.04
3ndvD-1vcvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 12 ALA A 190
GLY A 192
SER A 220
ASP A   6
SER A 148
 None
 1.06A 3pfgA-1vcvA:
2.8		 3pfgA-1vcvA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 10 ALA A 142
VAL A  85
PRO A  88
ALA A  87
VAL A 118
 None
 1.02A 3t3cB-1vcvA:
undetectable		 3t3cB-1vcvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		3 / 3 ARG A  95
ARG A  96
TRP A  97
 None
 1.20A 4cpzC-1vcvA:
undetectable		 4cpzC-1vcvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		3 / 3 ARG A  95
ARG A  96
TRP A  97
 None
 1.28A 4cpzE-1vcvA:
undetectable		 4cpzE-1vcvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		3 / 3 ARG A  95
ARG A  96
TRP A  97
 None
 1.17A 4cpzH-1vcvA:
undetectable		 4cpzH-1vcvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		5 / 12 GLY A 150
GLY A 191
ARG A 194
ILE A 119
LEU A   9
 None
 1.14A 5fa8A-1vcvA:
undetectable		 5fa8A-1vcvA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Pyrobaculum
aerophilum) 		4 / 7 VAL A  73
SER A  74
ALA A  77
GLY A 113
 None
 0.76A 5fpdB-1vcvA:
1.9		 5fpdB-1vcvA:
21.88