SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.06A 1v54A-1vczA:
undetectable
1v54J-1vczA:
undetectable		 1v54A-1vczA:
16.25
1v54J-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.04A 2dyrA-1vczA:
undetectable
2dyrJ-1vczA:
undetectable		 2dyrA-1vczA:
16.25
2dyrJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.04A 2dysA-1vczA:
undetectable
2dysJ-1vczA:
undetectable		 2dysA-1vczA:
16.25
2dysJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.05A 2eijA-1vczA:
undetectable
2eijJ-1vczA:
undetectable		 2eijA-1vczA:
16.25
2eijJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 7 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.03A 2eikA-1vczA:
undetectable
2eikJ-1vczA:
undetectable		 2eikA-1vczA:
16.25
2eikJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.06A 2eilA-1vczA:
undetectable
2eilJ-1vczA:
undetectable		 2eilA-1vczA:
16.25
2eilJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.07A 2eimJ-1vczA:
undetectable		 2eimJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.01A 2eimW-1vczA:
undetectable		 2eimW-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		3 / 3 ASP A   5
ASP A 177
ASP A   3
 None
 0.73A 2igtB-1vczA:
undetectable		 2igtB-1vczA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		5 / 9 ILE A 169
ILE A 157
PHE A  36
ALA A 146
LEU A 125
 None
 1.00A 2m9qA-1vczA:
undetectable		 2m9qA-1vczA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 7 ILE A 147
ARG A 116
PHE A  36
PHE A 201
 None
 1.15A 2qb4A-1vczA:
undetectable		 2qb4A-1vczA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.02A 2zxwA-1vczA:
undetectable
2zxwJ-1vczA:
undetectable		 2zxwA-1vczA:
16.25
2zxwJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 7 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.05A 3ablA-1vczA:
undetectable
3ablJ-1vczA:
undetectable		 3ablA-1vczA:
16.25
3ablJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.06A 3abmA-1vczA:
undetectable
3abmJ-1vczA:
undetectable		 3abmA-1vczA:
16.25
3abmJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.18A 3ag1J-1vczA:
undetectable		 3ag1J-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.04A 3ag2J-1vczA:
undetectable		 3ag2J-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.04A 3ag4J-1vczA:
undetectable		 3ag4J-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.04A 3asnA-1vczA:
undetectable
3asnJ-1vczA:
undetectable		 3asnA-1vczA:
16.25
3asnJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.03A 3asoA-1vczA:
undetectable
3asoJ-1vczA:
undetectable		 3asoA-1vczA:
16.25
3asoJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		3 / 3 GLN A  52
THR A  99
ASN A  53
 None
 0.68A 3v4tE-1vczA:
0.0		 3v4tE-1vczA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 8 ILE A 147
LEU A 125
ILE A 199
PHE A 201
 None
 0.83A 4hb8A-1vczA:
undetectable		 4hb8A-1vczA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.42A 4jksA-1vczA:
undetectable		 4jksA-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.42A 4jksB-1vczA:
undetectable		 4jksB-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.43A 4jkuA-1vczA:
undetectable		 4jkuA-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_2
(SUGAR KINASE)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.39A 4k8cB-1vczA:
undetectable		 4k8cB-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_2
(SUGAR KINASE)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.41A 4k8kA-1vczA:
undetectable		 4k8kA-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_2
(SUGAR KINASE)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.42A 4k8kB-1vczA:
undetectable		 4k8kB-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.43A 4kalA-1vczA:
undetectable		 4kalA-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.42A 4kalB-1vczA:
undetectable		 4kalB-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.41A 4lcaA-1vczA:
undetectable		 4lcaA-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 4 SER A 101
LEU A  60
TYR A 108
PRO A  51
 None
 1.40A 4lcaB-1vczA:
undetectable		 4lcaB-1vczA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 SER A 154
GLU A 148
GLY A 192
GLY A 194
 None
 0.81A 5cdpA-1vczA:
undetectable
5cdpB-1vczA:
undetectable		 5cdpA-1vczA:
17.76
5cdpB-1vczA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 6 THR A 179
ALA A 180
THR A 181
VAL A 176
 None
 0.94A 5ecoA-1vczA:
undetectable		 5ecoA-1vczA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 8 SER A  37
PHE A 204
PHE A  89
PRO A  27
 None
None
5GP  A 296 (-3.9A)
None
 1.08A 5vkqB-1vczA:
undetectable
5vkqC-1vczA:
undetectable		 5vkqB-1vczA:
7.56
5vkqC-1vczA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.20A 5w97J-1vczA:
undetectable		 5w97J-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.13A 5wauJ-1vczA:
0.0		 5wauJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.36A 5x19J-1vczA:
undetectable		 5x19J-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.48A 5x1bJ-1vczA:
undetectable		 5x1bJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.15A 5x1bW-1vczA:
undetectable		 5x1bW-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.08A 5x1fW-1vczA:
0.0		 5x1fW-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vcz RNASE NGR3
(Nicotiana
glutinosa) 		4 / 5 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.14A 6nknJ-1vczA:
undetectable		 6nknJ-1vczA:
15.54