SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vd6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		4 / 8 LEU A  32
ALA A  16
GLY A 213
ILE A 212
 None
None
None
GOL  A 300 ( 4.9A)
 0.79A 1d4sB-1vd6A:
undetectable		 1d4sB-1vd6A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		4 / 8 LEU A  32
ALA A  16
GLY A 213
ILE A 212
 None
None
None
GOL  A 300 ( 4.9A)
 0.70A 1d4yB-1vd6A:
undetectable		 1d4yB-1vd6A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		4 / 8 SER A 103
PHE A 104
GLY A 106
PHE A  51
 None
 0.92A 1fapB-1vd6A:
undetectable		 1fapB-1vd6A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		3 / 4 VAL A 189
TRP A 192
TRP A 182
 None
GOL  A 300 (-4.0A)
None
 1.21A 1gmkC-1vd6A:
undetectable
1gmkD-1vd6A:
undetectable		 1gmkC-1vd6A:
8.57
1gmkD-1vd6A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		4 / 4 ASP A  37
LEU A 211
LEU A 219
LEU A   9
 None
 1.31A 1u18A-1vd6A:
undetectable		 1u18A-1vd6A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		4 / 5 LEU A 211
VAL A  43
LEU A 101
ARG A 122
 None
 1.09A 2oiqA-1vd6A:
undetectable		 2oiqA-1vd6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		3 / 3 ASP A  42
THR A  59
PRO A  60
 GOL  A 300 ( 4.8A)
None
None
 0.67A 2pynB-1vd6A:
undetectable		 2pynB-1vd6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		3 / 3 ASP A  42
THR A  59
PRO A  60
 GOL  A 300 ( 4.8A)
None
None
 0.65A 2qakB-1vd6A:
undetectable		 2qakB-1vd6A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		3 / 3 GLU A 100
HIS A  13
GLU A  40
 GOL  A 300 (-3.0A)
GOL  A 300 (-3.9A)
GOL  A 300 (-3.4A)
 0.73A 2x45B-1vd6A:
undetectable		 2x45B-1vd6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		3 / 3 GLU A 100
HIS A  13
GLU A  40
 GOL  A 300 (-3.0A)
GOL  A 300 (-3.9A)
GOL  A 300 (-3.4A)
 0.74A 2x45C-1vd6A:
undetectable		 2x45C-1vd6A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		5 / 10 ALA A 111
LEU A 147
LEU A 135
SER A 103
LEU A 138
 None
 1.13A 2xn7A-1vd6A:
undetectable
2xn7B-1vd6A:
undetectable		 2xn7A-1vd6A:
20.17
2xn7B-1vd6A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		4 / 7 LEU A  32
ALA A  16
GLY A 213
ILE A 212
 None
None
None
GOL  A 300 ( 4.9A)
 0.78A 3spkB-1vd6A:
undetectable		 3spkB-1vd6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		5 / 10 LEU A 145
ASN A  98
VAL A  96
LEU A  11
LEU A   9
 None
 1.19A 4po0A-1vd6A:
undetectable		 4po0A-1vd6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		5 / 9 ALA A 111
LEU A 147
LEU A 115
LEU A 138
ARG A 139
 None
 1.36A 4x30A-1vd6A:
0.0		 4x30A-1vd6A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermus
thermophilus) 		5 / 10 LEU A  18
ALA A  20
LEU A  30
GLY A  12
HIS A  13
 None
None
None
None
GOL  A 300 (-3.9A)
 1.42A 5dxbA-1vd6A:
undetectable		 5dxbA-1vd6A:
22.18