SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vdc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		3 / 3 ILE A 112
LEU A 110
VAL A 108
 FAD  A 400 (-3.7A)
None
None
 0.44A 1mz9B-1vdcA:
undetectable		 1mz9B-1vdcA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 10 LEU A  43
ALA A  17
VAL A  49
GLN A 294
ASP A 286
 FAD  A 400 (-4.1A)
None
FAD  A 400 (-3.5A)
FAD  A 400 (-3.8A)
FAD  A 400 ( 2.8A)
 1.00A 1rlbE-1vdcA:
undetectable		 1rlbE-1vdcA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 HIS A  18
GLY A 285
GLY A 302
LEU A 110
PHE A  68
 None
FAD  A 400 ( 3.2A)
None
None
None
 0.95A 1zq9B-1vdcA:
4.7		 1zq9B-1vdcA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 PHE A 251
THR A 249
VAL A 287
VAL A 256
 FAD  A 400 ( 3.7A)
None
None
None
 1.07A 2cppA-1vdcA:
0.0		 2cppA-1vdcA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 THR A 276
THR A 274
THR A 273
GLY A 280
ALA A 309
 None
 1.11A 2f162-1vdcA:
undetectable		 2f162-1vdcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 THR A 276
THR A 274
THR A 273
GLY A 280
ALA A 309
 None
 1.11A 2f16N-1vdcA:
undetectable		 2f16N-1vdcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 10 PHE A 251
VAL A 108
VAL A 281
VAL A 287
ILE A 112
 FAD  A 400 ( 3.7A)
None
None
None
FAD  A 400 (-3.7A)
 1.13A 2qboA-1vdcA:
undetectable		 2qboA-1vdcA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 285
ASP A 289
ALA A 299
GLY A 300
ILE A 109
 FAD  A 400 ( 3.2A)
None
None
None
None
 0.95A 3ku1C-1vdcA:
4.6		 3ku1C-1vdcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ALA A 283
VAL A 278
VAL A 281
LEU A 110
 None
 0.76A 3o14A-1vdcA:
undetectable		 3o14A-1vdcA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 VAL A  11
PHE A 251
VAL A 287
PHE A  89
 FAD  A 400 (-4.8A)
FAD  A 400 ( 3.7A)
None
None
 1.12A 3soaA-1vdcA:
1.9		 3soaA-1vdcA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 VAL A  49
ASN A  51
ILE A 296
LEU A  64
PHE A  68
 FAD  A 400 (-3.5A)
FAD  A 400 ( 3.2A)
None
None
None
 1.10A 3t3rA-1vdcA:
undetectable		 3t3rA-1vdcA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 11 VAL A 204
PHE A 121
ILE A 243
GLY A 152
LEU A 239
 None
 1.16A 3t3rA-1vdcA:
undetectable		 3t3rA-1vdcA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 PRO A  53
LEU A  64
LEU A  43
ILE A 296
 None
None
FAD  A 400 (-4.1A)
None
 0.99A 3u5jA-1vdcA:
undetectable		 3u5jA-1vdcA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 8 PRO A  53
LEU A  64
LEU A  43
ILE A 296
 None
None
FAD  A 400 (-4.1A)
None
 0.89A 3u5kA-1vdcA:
undetectable		 3u5kA-1vdcA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 PHE A 251
LEU A  96
VAL A 108
VAL A  87
CYH A   9
 FAD  A 400 ( 3.7A)
None
None
None
None
 1.34A 3u9fJ-1vdcA:
undetectable
3u9fK-1vdcA:
undetectable		 3u9fJ-1vdcA:
20.57
3u9fK-1vdcA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 252
LEU A 110
ILE A 109
THR A 276
 None
 1.00A 4do3B-1vdcA:
undetectable		 4do3B-1vdcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		3 / 3 ARG A 144
TYR A 172
ASN A 193
 None
 0.73A 4ffwB-1vdcA:
undetectable		 4ffwB-1vdcA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 ILE A 112
ALA A  17
VAL A 278
LEU A 110
LEU A  96
 FAD  A 400 (-3.7A)
None
None
None
None
 1.19A 4qzuC-1vdcA:
undetectable		 4qzuC-1vdcA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.67A 5bs8A-1vdcA:
undetectable
5bs8C-1vdcA:
undetectable
5bs8D-1vdcA:
undetectable		 5bs8A-1vdcA:
20.90
5bs8C-1vdcA:
20.90
5bs8D-1vdcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.71A 5bs8A-1vdcA:
undetectable
5bs8B-1vdcA:
undetectable
5bs8C-1vdcA:
undetectable		 5bs8A-1vdcA:
20.90
5bs8B-1vdcA:
22.16
5bs8C-1vdcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.68A 5btaA-1vdcA:
0.0
5btaC-1vdcA:
0.0
5btaD-1vdcA:
undetectable		 5btaA-1vdcA:
20.90
5btaC-1vdcA:
20.90
5btaD-1vdcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.71A 5btaA-1vdcA:
undetectable
5btaB-1vdcA:
undetectable
5btaC-1vdcA:
undetectable		 5btaA-1vdcA:
20.90
5btaB-1vdcA:
22.16
5btaC-1vdcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.70A 5btcA-1vdcA:
undetectable
5btcC-1vdcA:
undetectable
5btcD-1vdcA:
undetectable		 5btcA-1vdcA:
20.90
5btcC-1vdcA:
20.90
5btcD-1vdcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.74A 5btcA-1vdcA:
undetectable
5btcB-1vdcA:
undetectable
5btcC-1vdcA:
undetectable		 5btcA-1vdcA:
20.90
5btcB-1vdcA:
22.16
5btcC-1vdcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.70A 5btdA-1vdcA:
undetectable
5btdB-1vdcA:
0.3
5btdC-1vdcA:
undetectable		 5btdA-1vdcA:
20.90
5btdB-1vdcA:
22.16
5btdC-1vdcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.67A 5btdA-1vdcA:
0.0
5btdC-1vdcA:
0.0
5btdD-1vdcA:
undetectable		 5btdA-1vdcA:
20.90
5btdC-1vdcA:
20.90
5btdD-1vdcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.70A 5btfA-1vdcA:
undetectable
5btfB-1vdcA:
undetectable
5btfC-1vdcA:
undetectable		 5btfA-1vdcA:
20.90
5btfB-1vdcA:
22.16
5btfC-1vdcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.67A 5btfA-1vdcA:
undetectable
5btfC-1vdcA:
undetectable
5btfD-1vdcA:
undetectable		 5btfA-1vdcA:
20.90
5btfC-1vdcA:
20.90
5btfD-1vdcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.75A 5btgA-1vdcA:
undetectable
5btgB-1vdcA:
undetectable
5btgC-1vdcA:
undetectable		 5btgA-1vdcA:
20.90
5btgB-1vdcA:
22.16
5btgC-1vdcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 7 ARG A  69
GLY A  40
THR A  81
GLU A  35
 None
 0.78A 5btgA-1vdcA:
undetectable
5btgC-1vdcA:
undetectable
5btgD-1vdcA:
undetectable		 5btgA-1vdcA:
20.90
5btgC-1vdcA:
20.90
5btgD-1vdcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		4 / 6 ARG A 293
ASP A 259
GLY A 261
ASP A 261
 None
 1.43A 5hp1C-1vdcA:
0.0		 5hp1C-1vdcA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 234
VAL A 226
LEU A 239
ILE A 151
ARG A 176
 None
 1.33A 5uahC-1vdcA:
0.0		 5uahC-1vdcA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE
(Arabidopsis
thaliana) 		3 / 3 LYS A 222
VAL A 231
ASP A 233
 None
 0.42A 6fgdA-1vdcA:
1.6		 6fgdA-1vdcA:
21.65