SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vdh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  14
GLY A  82
LEU A  79
ARG A 131
LEU A 114
 None
 0.93A 1eizA-1vdhA:
undetectable		 1eizA-1vdhA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A 172
SER A 223
ARG A 218
TYR A 145
 None
 1.19A 1eqbA-1vdhA:
undetectable
1eqbB-1vdhA:
undetectable		 1eqbA-1vdhA:
19.48
1eqbB-1vdhA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A 145
HIS A 172
SER A 223
ARG A 218
 None
 1.18A 1eqbA-1vdhA:
undetectable
1eqbB-1vdhA:
undetectable		 1eqbA-1vdhA:
19.48
1eqbB-1vdhA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A 172
SER A 223
ARG A 218
TYR A 145
 None
 1.18A 1eqbC-1vdhA:
undetectable
1eqbD-1vdhA:
undetectable		 1eqbC-1vdhA:
19.48
1eqbD-1vdhA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A 145
HIS A 172
SER A 223
ARG A 218
 None
 1.18A 1eqbC-1vdhA:
undetectable
1eqbD-1vdhA:
undetectable		 1eqbC-1vdhA:
19.48
1eqbD-1vdhA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 8 ILE A 187
VAL A 214
MET A 217
SER A 223
 None
 1.10A 1kb9A-1vdhA:
0.0
1kb9C-1vdhA:
0.0
1kb9D-1vdhA:
0.0
1kb9E-1vdhA:
0.0		 1kb9A-1vdhA:
20.50
1kb9C-1vdhA:
19.85
1kb9D-1vdhA:
23.05
1kb9E-1vdhA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A 145
HIS A 172
SER A 223
ARG A 218
 None
 1.23A 2vmyA-1vdhA:
undetectable
2vmyB-1vdhA:
undetectable		 2vmyA-1vdhA:
22.44
2vmyB-1vdhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 SER A 110
PRO A 134
VAL A 112
LEU A 114
ILE A 187
 None
 1.36A 2xrlA-1vdhA:
undetectable		 2xrlA-1vdhA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		3 / 3 TYR A  62
TYR A 237
GLU A  56
 None
 0.90A 3pfgA-1vdhA:
undetectable		 3pfgA-1vdhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  67
PHE A 233
GLY A 235
VAL A 142
PHE A 144
 None
 0.43A 4bvaA-1vdhA:
undetectable		 4bvaA-1vdhA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  67
PHE A 233
GLY A 235
VAL A 142
PHE A 144
 None
 0.48A 4bvaB-1vdhA:
undetectable		 4bvaB-1vdhA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 6 GLU A 113
THR A  11
GLN A 191
LEU A 193
 None
 1.41A 4qzuC-1vdhA:
undetectable		 4qzuC-1vdhA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		4 / 7 VAL A 136
ILE A  64
TRP A  51
LEU A  86
 None
 1.22A 4xo7B-1vdhA:
undetectable		 4xo7B-1vdhA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		3 / 3 VAL A 183
TYR A 179
GLN A 180
 None
 0.75A 5qgkA-1vdhA:
undetectable		 5qgkA-1vdhA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A 186
GLY A 189
VAL A 112
GLU A 197
TYR A 106
 None
 1.24A 5x7fA-1vdhA:
undetectable		 5x7fA-1vdhA:
22.79