SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vdk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 12 LYS A 216
THR A 369
SER A 372
ILE A 373
LEU A 156
 None
 0.77A 1ddrA-1vdkA:
undetectable		 1ddrA-1vdkA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		4 / 4 ILE A 373
LEU A 376
VAL A 380
ALA A 388
 None
 0.92A 1mz9A-1vdkA:
undetectable		 1mz9A-1vdkA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		4 / 5 ILE A 373
LEU A 376
VAL A 380
ALA A 388
 None
 0.98A 1mz9C-1vdkA:
undetectable		 1mz9C-1vdkA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 12 LYS A 216
THR A 369
SER A 372
ILE A 373
LEU A 156
 None
 0.82A 1rg7A-1vdkA:
undetectable		 1rg7A-1vdkA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		4 / 7 THR A 170
VAL A 380
VAL A 295
ILE A 291
 None
 0.91A 1t87B-1vdkA:
undetectable		 1t87B-1vdkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		4 / 8 THR A 170
VAL A 380
VAL A 295
ILE A 291
 None
 0.78A 2a1mB-1vdkA:
undetectable		 2a1mB-1vdkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_2
(NEURAMINIDASE)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		4 / 4 ASP A 294
TRP A 297
ILE A 306
ARG A 186
 None
 1.48A 2htqA-1vdkA:
undetectable		 2htqA-1vdkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 8 ILE A 111
ILE A  46
ASN A 135
VAL A 134
ALA A 128
 None
 1.40A 2nniA-1vdkA:
undetectable		 2nniA-1vdkA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		4 / 8 THR A 170
VAL A 380
VAL A 295
ILE A 291
 None
 0.82A 2qbmA-1vdkA:
undetectable		 2qbmA-1vdkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		3 / 3 MET A 365
GLU A 273
ASN A 263
 None
 0.97A 3a27A-1vdkA:
undetectable		 3a27A-1vdkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 11 GLN A  83
LEU A 250
VAL A 150
ALA A 153
THR A 254
 None
 1.35A 3n23C-1vdkA:
undetectable		 3n23C-1vdkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 12 ALA A 231
LEU A 236
GLY A 229
ALA A  56
ASN A 237
 None
 1.30A 3tm4A-1vdkA:
undetectable		 3tm4A-1vdkA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		4 / 5 LEU A  66
ALA A  56
PHE A 242
ASN A 108
 None
 1.44A 3uq6A-1vdkA:
undetectable		 3uq6A-1vdkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		4 / 4 LEU A  66
ALA A  56
PHE A 242
ASN A 108
 None
 1.47A 3vaqA-1vdkA:
undetectable		 3vaqA-1vdkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		4 / 4 LEU A  66
ALA A  56
PHE A 242
ASN A 108
 None
 1.45A 3vasA-1vdkA:
undetectable		 3vasA-1vdkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 12 LYS A 216
THR A 369
SER A 372
ILE A 373
LEU A 156
 None
 0.78A 4dfrA-1vdkA:
undetectable		 4dfrA-1vdkA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 12 ASP A 142
VAL A 246
ALA A 247
GLY A 137
PHE A 242
 None
 1.20A 4mm8A-1vdkA:
undetectable		 4mm8A-1vdkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 9 ASP A 142
VAL A 246
ALA A 247
GLY A 137
PHE A 242
 None
 1.30A 4mmbA-1vdkA:
undetectable		 4mmbA-1vdkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 9 ASP A 142
VAL A 246
ALA A 247
GLY A 137
PHE A 242
 None
 1.23A 4mmeA-1vdkA:
undetectable		 4mmeA-1vdkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 9 ASP A 142
VAL A 246
ALA A 247
GLY A 137
PHE A 242
 None
 1.18A 4mmeB-1vdkA:
undetectable		 4mmeB-1vdkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 9 ASP A 142
VAL A 246
ALA A 247
GLY A 137
PHE A 242
 None
 1.20A 4mmfA-1vdkA:
undetectable		 4mmfA-1vdkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 9 ASP A 142
VAL A 246
ALA A 247
GLY A 137
PHE A 242
 None
 1.19A 4mmfB-1vdkA:
1.0		 4mmfB-1vdkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 10 ASN A 359
VAL A 275
LEU A 274
MET A 148
PHE A 144
 None
 1.48A 4r3aB-1vdkA:
undetectable		 4r3aB-1vdkA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 11 ALA A 381
GLU A 165
LEU A 208
LEU A 284
LEU A 288
 None
 1.12A 4wg0K-1vdkA:
undetectable
4wg0L-1vdkA:
undetectable
4wg0M-1vdkA:
undetectable		 4wg0K-1vdkA:
2.16
4wg0L-1vdkA:
2.16
4wg0M-1vdkA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 11 GLY A 137
ASP A 132
ASN A  60
LYS A  53
ILE A  74
 None
 0.98A 4ypeB-1vdkA:
undetectable		 4ypeB-1vdkA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		3 / 3 ARG A 339
TYR A 367
GLU A 371
 None
 0.67A 4zzbE-1vdkA:
2.5		 4zzbE-1vdkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		3 / 3 ARG A  58
LYS A 248
GLU A 252
 None
 0.77A 5d0yA-1vdkA:
1.7		 5d0yA-1vdkA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 12 ALA A 128
ALA A  78
ILE A  75
LYS A  53
ALA A  57
 None
 1.01A 5eypB-1vdkA:
undetectable		 5eypB-1vdkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 10 GLU A  44
LEU A 358
ALA A 366
THR A  97
PRO A  42
 None
 1.28A 5mm4B-1vdkA:
undetectable		 5mm4B-1vdkA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 10 PRO A 130
HIS A 129
GLY A 228
ILE A 227
ALA A  56
 None
 1.25A 5vyhA-1vdkA:
undetectable		 5vyhA-1vdkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		5 / 12 TYR A 161
LEU A 212
HIS A 157
LEU A 256
LEU A 222
 None
 1.48A 5y2oA-1vdkA:
1.8		 5y2oA-1vdkA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		3 / 3 THR A 211
ALA A 287
LYS A 290
 None
 0.74A 6fgcA-1vdkA:
undetectable		 6fgcA-1vdkA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1vdk FUMARATE HYDRATASE
CLASS II
(Thermus
thermophilus) 		3 / 3 THR A 211
ALA A 287
LYS A 290
 None
 0.75A 6fgdA-1vdkA:
undetectable		 6fgdA-1vdkA:
24.22