SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 11 ALA A 238
VAL A 224
ILE A 202
GLY A 205
ILE A 208
 None
 0.94A 1n49B-1vdwA:
undetectable		 1n49B-1vdwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 11 ALA A 238
VAL A 224
ILE A 202
GLY A 205
ILE A 208
 None
 0.93A 1n49C-1vdwA:
undetectable		 1n49C-1vdwA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 11 THR A 169
GLY A 159
THR A 155
VAL A 191
ILE A 151
 None
EDO  A1003 (-3.8A)
EDO  A1003 ( 4.5A)
None
None
 1.07A 1phgA-1vdwA:
undetectable		 1phgA-1vdwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
ILE A 175
ALA A 176
ASP A 192
TYR A 196
 None
EDO  A1002 (-4.0A)
None
None
None
 1.13A 1ri4A-1vdwA:
undetectable		 1ri4A-1vdwA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 11 ALA A  50
ILE A  53
VAL A 101
PHE A 115
ILE A  14
 None
 1.11A 2h42A-1vdwA:
undetectable		 2h42A-1vdwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		6 / 12 LEU A 244
ILE A 193
GLY A 159
ILE A 163
ALA A 189
ILE A 248
 None
None
EDO  A1003 (-3.8A)
None
None
None
 1.23A 2nmzA-1vdwA:
undetectable		 2nmzA-1vdwA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 11 ALA A 238
VAL A 224
ILE A 202
GLY A 205
ILE A 208
 None
 1.05A 2nnpB-1vdwA:
undetectable		 2nnpB-1vdwA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 12 ALA A 239
ASP A 188
ILE A 151
ILE A 236
LEU A 249
 None
 0.97A 2o4nA-1vdwA:
undetectable		 2o4nA-1vdwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		4 / 7 TYR A 113
ILE A 128
GLY A 127
LEU A 135
 None
 0.97A 2vctD-1vdwA:
1.1		 2vctD-1vdwA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 9 ALA A 238
VAL A 224
ILE A 202
GLY A 205
ILE A 208
 None
 1.15A 3el4B-1vdwA:
undetectable		 3el4B-1vdwA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 12 ALA A 238
VAL A 224
ILE A 202
GLY A 205
ILE A 208
 None
 1.10A 3mwsB-1vdwA:
undetectable		 3mwsB-1vdwA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 12 ILE A 226
VAL A 234
ALA A 238
ILE A 175
PHE A 153
 None
None
None
EDO  A1002 (-4.0A)
None
 0.99A 3w67C-1vdwA:
undetectable		 3w67C-1vdwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		4 / 8 GLY A 127
GLY A 205
LEU A 179
LEU A 182
 None
 0.72A 4mwzB-1vdwA:
0.1		 4mwzB-1vdwA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		4 / 6 THR A 247
ASN A 240
LEU A 182
GLU A 178
 None
 1.21A 4nc3A-1vdwA:
undetectable		 4nc3A-1vdwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 12 ALA A 238
VAL A 224
ILE A 202
GLY A 205
ILE A 208
 None
 1.05A 4njuA-1vdwA:
undetectable		 4njuA-1vdwA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 12 ALA A 238
VAL A 224
ILE A 202
GLY A 205
ILE A 208
 None
 1.05A 4njuC-1vdwA:
undetectable		 4njuC-1vdwA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 12 ALA A 238
VAL A 224
ILE A 202
GLY A 205
ILE A 208
 None
 1.11A 4njvD-1vdwA:
undetectable		 4njvD-1vdwA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 9 ALA A 214
ILE A 208
GLY A 205
ILE A 202
VAL A 142
 None
 1.15A 4nptA-1vdwA:
undetectable		 4nptA-1vdwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		5 / 12 ALA A 104
ILE A  55
GLU A  51
VAL A  65
ILE A  70
 None
 1.12A 4uw0A-1vdwA:
undetectable		 4uw0A-1vdwA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		4 / 4 ASN A 240
SER A 150
ALA A 189
VAL A 190
 None
 1.23A 4x1kC-1vdwA:
undetectable		 4x1kC-1vdwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		3 / 3 LEU A 172
ASP A  87
ILE A 151
 None
EDO  A1002 (-2.8A)
None
 0.58A 4xi3D-1vdwA:
undetectable		 4xi3D-1vdwA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		4 / 7 ARG A 123
TYR A 125
GLU A 118
LEU A 187
 None
 1.04A 5umwB-1vdwA:
0.0
5umwE-1vdwA:
0.0		 5umwB-1vdwA:
14.17
5umwE-1vdwA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1vdw HYPOTHETICAL PROTEIN
PH1897
(Pyrococcus
horikoshii) 		4 / 4 LEU A 145
LEU A 244
SER A 150
ALA A 189
 None
 1.06A 5uunA-1vdwA:
undetectable		 5uunA-1vdwA:
24.53