SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ve1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 SER A 264
GLY A 261
LEU A 300
GLY A 266
PHE A 217
 None
 1.20A 1fduC-1ve1A:
3.4		 1fduC-1ve1A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 11 SER A 264
GLY A 261
LEU A 300
GLY A 266
PHE A 217
 None
 1.25A 1iolA-1ve1A:
3.8		 1iolA-1ve1A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 LEU A 233
VAL A 148
TYR A 152
GLY A 178
 None
None
None
PLP  A 413 (-3.9A)
 1.03A 1lweA-1ve1A:
0.0		 1lweA-1ve1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 MET A  96
ASN A  72
GLN A 141
 None
PLP  A 413 (-3.6A)
None
 0.73A 1xoqB-1ve1A:
undetectable		 1xoqB-1ve1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 11 GLY A 173
SER A 174
LEU A 229
ILE A 238
ALA A 270
 None
PLP  A 413 ( 3.9A)
None
None
None
 1.18A 2a58A-1ve1A:
2.3
2a58E-1ve1A:
2.4		 2a58A-1ve1A:
22.70
2a58E-1ve1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 238
ALA A 270
GLY A 173
SER A 174
LEU A 229
 None
None
None
PLP  A 413 ( 3.9A)
None
 1.20A 2a58A-1ve1A:
2.3
2a58B-1ve1A:
2.4		 2a58A-1ve1A:
22.70
2a58B-1ve1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 238
ALA A 270
GLY A 173
SER A 174
LEU A 229
 None
None
None
PLP  A 413 ( 3.9A)
None
 1.20A 2a58B-1ve1A:
2.4
2a58C-1ve1A:
2.4		 2a58B-1ve1A:
22.70
2a58C-1ve1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 11 ILE A 238
ALA A 270
GLY A 173
SER A 174
LEU A 229
 None
None
None
PLP  A 413 ( 3.9A)
None
 1.18A 2a58C-1ve1A:
2.4
2a58D-1ve1A:
2.4		 2a58C-1ve1A:
22.70
2a58D-1ve1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 238
ALA A 270
GLY A 173
SER A 174
LEU A 229
 None
None
None
PLP  A 413 ( 3.9A)
None
 1.20A 2a58D-1ve1A:
2.4
2a58E-1ve1A:
2.4		 2a58D-1ve1A:
22.70
2a58E-1ve1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 11 GLU A 200
ALA A 198
PRO A 201
ALA A 270
ASP A 235
 None
 1.27A 2admA-1ve1A:
2.0		 2admA-1ve1A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 11 GLU A 200
ALA A 198
PRO A 201
ALA A 270
ASP A 235
 None
 1.29A 2admB-1ve1A:
2.0		 2admB-1ve1A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 GLY A 265
PHE A 246
PRO A 247
ASP A 244
 None
 1.02A 2aouB-1ve1A:
2.8		 2aouB-1ve1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 GLU A   4
ILE A  80
GLU A  52
ILE A  48
 None
 0.94A 2j9dJ-1ve1A:
0.0
2j9dK-1ve1A:
undetectable
2j9dL-1ve1A:
0.0		 2j9dJ-1ve1A:
18.67
2j9dK-1ve1A:
18.67
2j9dL-1ve1A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ALA A 127
THR A  91
ALA A 109
ALA A  78
LEU A  57
 None
 1.16A 2nyrA-1ve1A:
2.8		 2nyrA-1ve1A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 LEU A  88
ALA A 136
LEU A 130
ALA A 127
 None
 0.90A 2vcvB-1ve1A:
undetectable		 2vcvB-1ve1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 LEU A  88
ALA A 136
LEU A 130
ALA A 127
 None
 0.90A 2vcvF-1ve1A:
undetectable		 2vcvF-1ve1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 LEU A  88
ALA A 136
LEU A 130
ALA A 127
 None
 0.82A 2vcvK-1ve1A:
undetectable		 2vcvK-1ve1A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 8 LEU A  88
ILE A  65
LEU A  77
THR A  69
LEU A  90
 None
 1.27A 2xfhA-1ve1A:
undetectable		 2xfhA-1ve1A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 207
SER A 174
ILE A 225
LEU A 231
ASP A 230
 None
PLP  A 413 ( 3.9A)
None
None
None
 1.23A 3ko0G-1ve1A:
0.0
3ko0H-1ve1A:
undetectable
3ko0I-1ve1A:
0.0
3ko0J-1ve1A:
0.0		 3ko0G-1ve1A:
16.56
3ko0H-1ve1A:
16.56
3ko0I-1ve1A:
16.56
3ko0J-1ve1A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 234
GLY A 173
PRO A 201
GLY A 177
ILE A  39
 None
None
None
PLP  A 413 (-3.8A)
None
 0.93A 3ku1A-1ve1A:
5.0		 3ku1A-1ve1A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 234
GLY A 173
PRO A 201
GLY A 177
ILE A  39
 None
None
None
PLP  A 413 (-3.8A)
None
 0.90A 3ku1C-1ve1A:
2.1		 3ku1C-1ve1A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 234
GLY A 173
PRO A 201
GLY A 177
ILE A  39
 None
None
None
PLP  A 413 (-3.8A)
None
 0.89A 3ku1G-1ve1A:
2.6		 3ku1G-1ve1A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 9 GLY A 108
ILE A  89
GLY A  74
ILE A  75
LEU A 111
 None
 0.93A 3ogpB-1ve1A:
undetectable		 3ogpB-1ve1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 5 GLY A 221
GLU A 200
GLY A 223
PRO A 201
 None
 1.03A 3onnA-1ve1A:
2.3		 3onnA-1ve1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 GLY A 175
GLY A 177
THR A 179
 PLP  A 413 (-3.5A)
PLP  A 413 (-3.8A)
PLP  A 413 (-3.5A)
 0.31A 3si7B-1ve1A:
undetectable		 3si7B-1ve1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 9 PHE A 259
GLY A 266
GLY A 261
HIS A 215
GLN A 218
 None
 1.18A 4l8wI-1ve1A:
1.4		 4l8wI-1ve1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 SER A 288
SER A  38
GLU A  99
TYR A 301
GLY A 292
 None
PLP  A 413 ( 4.8A)
None
None
None
 1.49A 4qb9E-1ve1A:
undetectable		 4qb9E-1ve1A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 10 GLY A  60
TYR A  86
SER A  83
ARG A   2
GLU A   4
 None
 1.37A 5hwkA-1ve1A:
undetectable		 5hwkA-1ve1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 10 GLY A  60
TYR A  86
SER A  83
ARG A   2
GLU A   4
 None
 1.36A 5hwkB-1ve1A:
undetectable		 5hwkB-1ve1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 167
THR A  10
GLU A  31
ALA A 275
ILE A 180
 None
 1.25A 5iwuA-1ve1A:
undetectable		 5iwuA-1ve1A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ALA A  78
PHE A 246
TYR A 301
GLY A 265
THR A  73
 None
 1.33A 5jlcA-1ve1A:
undetectable		 5jlcA-1ve1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 GLU A 255
LEU A 252
ARG A 250
ARG A 251
 None
 1.29A 5l6eA-1ve1A:
1.5
5l6eB-1ve1A:
undetectable		 5l6eA-1ve1A:
23.55
5l6eB-1ve1A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 ARG A  84
ILE A  80
SER A  83
 None
 0.72A 5zw2A-1ve1A:
undetectable		 5zw2A-1ve1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 5 ASN A  72
TYR A 172
VAL A 199
SER A 288
 PLP  A 413 (-3.6A)
PLP  A 413 (-4.4A)
None
None
 1.23A 6a7pA-1ve1A:
undetectable		 6a7pA-1ve1A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 9 GLU A 200
VAL A 237
GLY A 175
SER A 174
LEU A 229
 None
None
PLP  A 413 (-3.5A)
PLP  A 413 ( 3.9A)
None
 1.34A 6cdqA-1ve1A:
0.1		 6cdqA-1ve1A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 GLY A 177
LEU A 229
VAL A 206
LEU A 207
 PLP  A 413 (-3.8A)
None
None
None
 0.82A 6czmD-1ve1A:
undetectable
6czmF-1ve1A:
undetectable		 6czmD-1ve1A:
21.87
6czmF-1ve1A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 1ve1 O-ACETYLSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 9 THR A 179
GLY A 182
GLY A 184
VAL A 194
GLU A 158
 PLP  A 413 (-3.5A)
None
None
None
None
 1.47A 6gnfA-1ve1A:
3.4		 6gnfA-1ve1A:
21.39