SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ve3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		3 / 3 ASP A  67
ASP A  71
ASP A  93
 SAM  A 302 (-2.8A)
None
SAM  A 302 (-3.4A)
 0.67A 1eizA-1ve3A:
11.8		 1eizA-1ve3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		3 / 3 ASP A  67
ASP A  71
ASP A  93
 SAM  A 302 (-2.8A)
None
SAM  A 302 (-3.4A)
 0.68A 1ej0A-1ve3A:
11.6		 1ej0A-1ve3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 9 VAL A 128
VAL A  66
LEU A  43
ALA A  94
LEU A  97
 None
None
None
SAM  A 302 (-3.3A)
None
 1.21A 1eqgA-1ve3A:
undetectable		 1eqgA-1ve3A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 10 VAL A 124
VAL A  64
VAL A  66
ILE A  68
LEU A  97
 None
None
None
SAM  A 302 (-3.7A)
None
 1.01A 1fe2A-1ve3A:
undetectable		 1fe2A-1ve3A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 8 VAL A 124
VAL A  64
VAL A  66
ILE A  68
LEU A  97
 None
None
None
SAM  A 302 (-3.7A)
None
 0.96A 1igxA-1ve3A:
undetectable		 1igxA-1ve3A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
SER A  69
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.74A 1kiaA-1ve3A:
17.8		 1kiaA-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		4 / 5 ARG A  24
ASP A  67
SER A  69
SER A 112
 SAM  A 302 (-3.1A)
SAM  A 302 (-2.8A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
 0.81A 1kiaB-1ve3A:
17.7		 1kiaB-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		4 / 6 ARG A  24
ASP A  67
SER A  69
SER A 112
 SAM  A 302 (-3.1A)
SAM  A 302 (-2.8A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
 0.79A 1kiaC-1ve3A:
19.1		 1kiaC-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
SER A  69
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.75A 1kiaD-1ve3A:
17.4		 1kiaD-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
SER A  69
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.71A 1nbhA-1ve3A:
19.0		 1nbhA-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
SER A  69
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.72A 1nbhC-1ve3A:
20.0		 1nbhC-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
SER A  69
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.71A 1nbhD-1ve3A:
20.0		 1nbhD-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
SER A  69
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.91A 1nbiC-1ve3A:
18.3		 1nbiC-1ve3A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
SER A  69
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.89A 1nbiD-1ve3A:
18.4		 1nbiD-1ve3A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  50
GLY A  51
ILE A  68
ASP A  93
ARG A  95
 None
None
SAM  A 302 (-3.7A)
SAM  A 302 (-3.4A)
None
 0.45A 1sqfA-1ve3A:
12.8		 1sqfA-1ve3A:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		6 / 12 ALA A  46
ILE A  68
SER A  69
ALA A  94
ARG A  95
ILE A 108
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
None
None
 1.30A 1ve3A-1ve3A:
41.4		 1ve3A-1ve3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		12 / 12 TYR A   7
TYR A  13
ALA A  46
GLY A  48
ILE A  68
SER A  69
ALA A  94
ARG A  95
ILE A 110
SER A 112
HIS A 115
PHE A 116
 SAM  A 302 (-4.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
None
SAM  A 302 (-3.8A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
SAM  A 302 (-4.4A)
 0.02A 1ve3A-1ve3A:
41.4		 1ve3A-1ve3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		4 / 4 TYR A  21
ARG A  24
ASP A  67
ASP A  93
 SAM  A 302 (-4.7A)
SAM  A 302 (-3.1A)
SAM  A 302 (-2.8A)
SAM  A 302 (-3.4A)
 0.03A 1ve3A-1ve3A:
41.4		 1ve3A-1ve3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		6 / 12 ALA A  46
ILE A  68
SER A  69
ALA A  94
ARG A  95
ILE A 108
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
None
None
 1.27A 1ve3B-1ve3A:
35.3		 1ve3B-1ve3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		12 / 12 TYR A   7
TYR A  13
ALA A  46
GLY A  48
ILE A  68
SER A  69
ALA A  94
ARG A  95
ILE A 110
SER A 112
HIS A 115
PHE A 116
 SAM  A 302 (-4.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.3A)
None
SAM  A 302 (-3.8A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
SAM  A 302 (-4.4A)
 0.49A 1ve3B-1ve3A:
35.3		 1ve3B-1ve3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VE3_B_SAMB301_1
(HYPOTHETICAL PROTEIN
PH0226)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		4 / 4 TYR A  21
ARG A  24
ASP A  67
ASP A  93
 SAM  A 302 (-4.7A)
SAM  A 302 (-3.1A)
SAM  A 302 (-2.8A)
SAM  A 302 (-3.4A)
 0.10A 1ve3B-1ve3A:
35.3		 1ve3B-1ve3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		3 / 3 ASN A 225
TYR A 106
SER A 135
 None
 0.87A 2gvcB-1ve3A:
1.8		 2gvcB-1ve3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		3 / 3 ASN A 225
TYR A 106
SER A 135
 None
 0.85A 2gvcE-1ve3A:
1.8		 2gvcE-1ve3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 7 ALA A  46
GLY A  48
ASP A  67
ASP A  93
ARG A  95
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-2.8A)
SAM  A 302 (-3.4A)
None
 0.59A 2uyqA-1ve3A:
12.2		 2uyqA-1ve3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 TYR A  13
GLY A  48
ILE A  68
ASP A  93
PHE A 116
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.4A)
SAM  A 302 (-4.4A)
 1.41A 2zznB-1ve3A:
16.0		 2zznB-1ve3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		3 / 3 GLY A  48
ASP A  67
SER A  69
 SAM  A 302 (-3.6A)
SAM  A 302 (-2.8A)
SAM  A 302 (-4.7A)
 0.71A 3brfA-1ve3A:
undetectable		 3brfA-1ve3A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		6 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
ARG A  95
SER A 112
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
None
SAM  A 302 (-3.3A)
 0.53A 3bxoA-1ve3A:
19.9		 3bxoA-1ve3A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		6 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
ARG A  95
SER A 112
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
None
SAM  A 302 (-3.3A)
 0.76A 3bxoB-1ve3A:
19.4		 3bxoB-1ve3A:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		3 / 3 ASP A  67
ASP A  71
ASP A  93
 SAM  A 302 (-2.8A)
None
SAM  A 302 (-3.4A)
 0.62A 3douA-1ve3A:
11.9		 3douA-1ve3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
ASP A  93
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
 0.64A 3ou6A-1ve3A:
17.3		 3ou6A-1ve3A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
ASP A  93
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
 0.64A 3ou7A-1ve3A:
17.2		 3ou7A-1ve3A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		3 / 3 GLY A  48
ASP A  67
ASP A  93
 SAM  A 302 (-3.6A)
SAM  A 302 (-2.8A)
SAM  A 302 (-3.4A)
 0.42A 3ou7C-1ve3A:
17.2		 3ou7C-1ve3A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
ASP A  93
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
 0.65A 3ou7D-1ve3A:
17.2		 3ou7D-1ve3A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 TYR A   7
ALA A  46
GLY A  48
SER A  69
MET A  72
 SAM  A 302 (-4.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
 1.23A 3ou7D-1ve3A:
17.2		 3ou7D-1ve3A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		7 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
ASP A  93
SER A 112
HIS A 115
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.61A 3pfgA-1ve3A:
8.0		 3pfgA-1ve3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 TYR A   7
GLY A  48
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-4.6A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 1.12A 3pfgA-1ve3A:
8.0		 3pfgA-1ve3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		6 / 12 GLY A  48
ILE A  68
MET A  72
ASP A  93
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.78A 4iv0B-1ve3A:
19.3		 4iv0B-1ve3A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 TYR A   7
GLY A  48
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-4.6A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.90A 4iv0B-1ve3A:
19.3		 4iv0B-1ve3A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		6 / 12 GLY A  48
ASP A  67
ILE A  68
MET A  72
ASP A  93
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-2.8A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.8A)
 0.77A 4iv8A-1ve3A:
19.3		 4iv8A-1ve3A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		6 / 12 GLY A  48
ASP A  67
ILE A  68
MET A  72
ASP A  93
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-2.8A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.8A)
 0.83A 4iv8B-1ve3A:
19.2		 4iv8B-1ve3A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 LEU A  28
MET A  36
ILE A 110
ILE A 108
LEU A  55
 None
None
SAM  A 302 (-3.8A)
None
None
 1.08A 4j24B-1ve3A:
undetectable		 4j24B-1ve3A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		3 / 3 LYS A 133
PRO A 134
SER A 135
 None
 0.43A 4k50I-1ve3A:
undetectable		 4k50I-1ve3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
SER A  69
ASP A  93
ALA A  94
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.61A 4krhA-1ve3A:
18.9		 4krhA-1ve3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
ILE A  68
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.76A 4mwzA-1ve3A:
19.8		 4mwzA-1ve3A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 TYR A   7
GLY A  48
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-4.6A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.89A 4mwzA-1ve3A:
19.8		 4mwzA-1ve3A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 TYR A   7
ALA A  46
ILE A  68
MET A  72
PHE A 116
 SAM  A 302 (-4.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-4.4A)
 1.16A 4obwA-1ve3A:
7.6		 4obwA-1ve3A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 TYR A   7
ALA A  46
ILE A  68
MET A  72
PHE A 116
 SAM  A 302 (-4.6A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-4.4A)
 1.23A 4obwD-1ve3A:
18.1		 4obwD-1ve3A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
ILE A  68
SER A  69
MET A  72
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.8A)
 0.73A 4qdjA-1ve3A:
19.1		 4qdjA-1ve3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
ILE A  68
SER A  69
MET A  72
ILE A 110
 SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.8A)
 0.53A 4qtuB-1ve3A:
20.0		 4qtuB-1ve3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
ILE A  68
SER A  69
MET A  72
ILE A 110
 SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.8A)
 0.49A 4qtuD-1ve3A:
20.3		 4qtuD-1ve3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		4 / 6 LYS A 133
LEU A 132
ASN A 225
PRO A 226
 None
 1.41A 4yv5B-1ve3A:
undetectable		 4yv5B-1ve3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		4 / 6 LYS A 133
LEU A 132
ASN A 225
PRO A 226
 None
 1.40A 4yv5A-1ve3A:
undetectable		 4yv5A-1ve3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		4 / 4 ASP A  44
GLY A  48
ASP A  67
ASP A  93
 SAM  A 302 ( 4.8A)
SAM  A 302 (-3.6A)
SAM  A 302 (-2.8A)
SAM  A 302 (-3.4A)
 0.60A 5e72A-1ve3A:
17.2		 5e72A-1ve3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 ALA A  46
GLY A  48
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.94A 5gwxA-1ve3A:
20.3		 5gwxA-1ve3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 ALA A  46
GLY A  48
PHE A  52
MET A  72
HIS A 115
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 ( 4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.8A)
 1.00A 5gwxA-1ve3A:
20.3		 5gwxA-1ve3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 ALA A  46
GLY A  48
PHE A  52
SER A  69
MET A  72
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 ( 4.7A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
 0.94A 5gwxA-1ve3A:
20.3		 5gwxA-1ve3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 ALA A  46
GLY A  48
SER A  69
MET A  72
SER A 112
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
 0.41A 5gwxA-1ve3A:
20.3		 5gwxA-1ve3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 ARG A  24
GLY A  48
SER A  69
MET A  72
ASP A  93
 SAM  A 302 (-3.1A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
 1.10A 5hikA-1ve3A:
20.6		 5hikA-1ve3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		5 / 12 GLY A  48
MET A  72
ASP A  93
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.96A 5hikA-1ve3A:
20.6		 5hikA-1ve3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		6 / 12 GLY A  48
SER A  69
MET A  72
ASP A  93
ARG A  95
SER A 112
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
None
SAM  A 302 (-3.3A)
 0.86A 5hikA-1ve3A:
20.6		 5hikA-1ve3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		7 / 12 ALA A  46
GLY A  51
SER A  69
ASP A  93
ALA A  94
ARG A  95
PHE A 116
 SAM  A 302 (-3.4A)
None
SAM  A 302 (-4.7A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
None
SAM  A 302 (-4.4A)
 1.21A 5zvgA-1ve3A:
13.3		 5zvgA-1ve3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1ve3 HYPOTHETICAL PROTEIN
PH0226
(Pyrococcus
horikoshii) 		7 / 12 ALA A  46
GLY A  51
SER A  69
ASP A  93
ALA A  94
ARG A  95
PHE A 116
 SAM  A 302 (-3.4A)
None
SAM  A 302 (-4.7A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
None
SAM  A 302 (-4.4A)
 1.20A 5zvgB-1ve3A:
13.3		 5zvgB-1ve3A:
22.68