SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ve4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 7 TYR A 115
GLU A  85
SER A 175
VAL A 154
 None
 1.15A 1tv8A-1ve4A:
undetectable		 1tv8A-1ve4A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 8 TYR A 115
GLU A  85
SER A 175
VAL A 154
 None
 1.15A 2fb2A-1ve4A:
undetectable		 2fb2A-1ve4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 7 TYR A 115
GLU A  85
SER A 175
VAL A 154
 None
 1.13A 2fb2B-1ve4A:
undetectable		 2fb2B-1ve4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 7 GLY A  72
ASP A  74
VAL A  75
ASP A 153
 None
 0.81A 2uyqA-1ve4A:
undetectable		 2uyqA-1ve4A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 5 ASP A 104
ARG A 110
ILE A 108
VAL A 152
 None
 1.08A 3eigA-1ve4A:
undetectable		 3eigA-1ve4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 12 LEU A  30
LEU A  23
VAL A  87
VAL A 192
GLU A  67
 None
 1.38A 3w1wB-1ve4A:
undetectable		 3w1wB-1ve4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 9 GLY A  72
VAL A  71
SER A 175
ASP A  74
VAL A  75
 None
 1.36A 4da6A-1ve4A:
undetectable		 4da6A-1ve4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		5 / 9 LEU A  23
ARG A 178
SER A 204
LEU A 200
ILE A 197
 None
 1.32A 4ubsA-1ve4A:
undetectable		 4ubsA-1ve4A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 6 ASP A  78
ALA A 120
THR A 113
TYR A 115
 None
 1.48A 4w5qA-1ve4A:
undetectable		 4w5qA-1ve4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 6 ASP A  78
ALA A 120
THR A 113
TYR A 115
 None
 1.49A 4z4cA-1ve4A:
undetectable		 4z4cA-1ve4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 6 ASP A  78
ALA A 120
THR A 113
TYR A 115
 None
 1.48A 4z4fA-1ve4A:
undetectable		 4z4fA-1ve4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Thermus
thermophilus) 		4 / 5 ASP A  78
ALA A 120
THR A 113
TYR A 115
 None
 1.49A 4z4gA-1ve4A:
undetectable		 4z4gA-1ve4A:
12.15