SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ve5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 8 ALA A 138
LEU A  68
LEU A  62
ALA A  59
LYS A  58
 None
 1.17A 1e7cA-1ve5A:
undetectable		 1e7cA-1ve5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 8 PHE A 243
THR A 242
ASP A 144
ILE A 219
 None
 0.96A 1ei6C-1ve5A:
undetectable		 1ei6C-1ve5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 7 VAL A 256
LEU A 302
ALA A 264
LEU A 261
 None
 0.79A 1pthA-1ve5A:
undetectable		 1pthA-1ve5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 7 VAL A 256
LEU A 302
ALA A 264
LEU A 261
 None
 0.79A 1pthB-1ve5A:
undetectable		 1pthB-1ve5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 8 GLY A 178
GLY A 180
GLY A 181
LEU A 183
 PLP  A 413 (-3.3A)
PLP  A 413 (-3.5A)
PLP  A 413 (-3.2A)
None
 0.60A 1qzzA-1ve5A:
2.8		 1qzzA-1ve5A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 8 GLY A 185
GLY A 181
GLY A 180
LEU A 182
 None
PLP  A 413 (-3.2A)
PLP  A 413 (-3.5A)
PLP  A 413 (-4.5A)
 0.66A 1qzzA-1ve5A:
2.8		 1qzzA-1ve5A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 LEU A 198
ALA A 172
LEU A 294
ALA A 286
ALA A 175
 None
 1.08A 1sa1A-1ve5A:
undetectable
1sa1B-1ve5A:
undetectable		 1sa1A-1ve5A:
20.30
1sa1B-1ve5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 LEU A 198
ALA A 172
LEU A 294
ALA A 286
ALA A 175
 None
 1.06A 1sa1C-1ve5A:
undetectable
1sa1D-1ve5A:
undetectable		 1sa1C-1ve5A:
20.30
1sa1D-1ve5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 ALA A 285
ALA A 286
LEU A 261
ALA A 260
LEU A 301
 None
 0.97A 2aclA-1ve5A:
undetectable
2aclE-1ve5A:
undetectable		 2aclA-1ve5A:
21.91
2aclE-1ve5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 7 LEU A  68
GLY A 151
ILE A  14
VAL A  80
ILE A 140
 None
 1.15A 2aojB-1ve5A:
undetectable		 2aojB-1ve5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 VAL A 177
PHE A  50
GLY A 185
ALA A 184
LEU A 246
 PLP  A 413 ( 4.4A)
PLP  A 413 (-4.6A)
None
None
None
 1.06A 2aylA-1ve5A:
0.9		 2aylA-1ve5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 10 ALA A  55
ALA A  59
LEU A  62
LEU A  68
ALA A 138
 None
 1.02A 2bxeA-1ve5A:
undetectable		 2bxeA-1ve5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 10 ALA A 187
THR A 188
ALA A 189
VAL A 250
GLY A 181
 None
None
None
None
PLP  A 413 (-3.2A)
 1.01A 2f16K-1ve5A:
undetectable
2f16L-1ve5A:
undetectable		 2f16K-1ve5A:
21.09
2f16L-1ve5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 10 ALA A 187
THR A 188
ALA A 189
VAL A 250
GLY A 181
 None
None
None
None
PLP  A 413 (-3.2A)
 1.01A 2f16Y-1ve5A:
undetectable
2f16Z-1ve5A:
undetectable		 2f16Y-1ve5A:
21.09
2f16Z-1ve5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 11 THR A 235
GLY A 178
GLY A 232
PHE A  50
PRO A 142
 None
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.7A)
PLP  A 413 (-4.6A)
None
 0.93A 2y7kA-1ve5A:
undetectable		 2y7kA-1ve5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 THR A 235
GLY A 178
GLY A 232
PHE A  50
PRO A 142
 None
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.7A)
PLP  A 413 (-4.6A)
None
 1.00A 2y7kC-1ve5A:
undetectable		 2y7kC-1ve5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 THR A 235
GLY A 178
GLY A 232
PHE A  50
PRO A 142
 None
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.7A)
PLP  A 413 (-4.6A)
None
 1.00A 2y7kD-1ve5A:
undetectable		 2y7kD-1ve5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 10 THR A 235
GLY A 178
GLY A 232
PHE A  50
PRO A 142
 None
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.7A)
PLP  A 413 (-4.6A)
None
 0.97A 2y7pA-1ve5A:
undetectable		 2y7pA-1ve5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 GLY A 153
GLY A 156
ALA A 187
LEU A   7
LEU A   4
 None
 0.96A 2yqzA-1ve5A:
2.1		 2yqzA-1ve5A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 GLY A 153
GLY A 156
ALA A 187
LEU A   7
LEU A   4
 None
 0.96A 2yqzB-1ve5A:
2.0		 2yqzB-1ve5A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 GLY A 185
GLY A 151
LEU A 238
ALA A 150
VAL A 148
 None
 1.09A 3av6A-1ve5A:
3.5		 3av6A-1ve5A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 LEU A 246
GLY A 178
GLY A 180
PHE A 243
LEU A 282
 None
PLP  A 413 (-3.3A)
PLP  A 413 (-3.5A)
None
None
 1.03A 3dh0A-1ve5A:
2.4		 3dh0A-1ve5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 LEU A 246
GLY A 178
GLY A 180
PHE A 243
LEU A 282
 None
PLP  A 413 (-3.3A)
PLP  A 413 (-3.5A)
None
None
 1.06A 3dh0B-1ve5A:
2.6		 3dh0B-1ve5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 7 ILE A 245
GLY A 181
VAL A 199
LEU A   7
 None
PLP  A 413 (-3.2A)
None
None
 0.90A 3elzA-1ve5A:
undetectable		 3elzA-1ve5A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 7 GLU A 203
LEU A 238
ASP A 209
THR A 235
 CA  A2001 (-3.6A)
None
CA  A2001 (-2.9A)
None
 0.91A 3mbgA-1ve5A:
undetectable
3mbgB-1ve5A:
undetectable		 3mbgA-1ve5A:
16.72
3mbgB-1ve5A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 GLY A 180
ASP A 209
ALA A 210
VAL A 177
GLU A  42
 PLP  A 413 (-3.5A)
CA  A2001 (-2.9A)
CA  A2001 ( 4.4A)
PLP  A 413 ( 4.4A)
None
 1.09A 3nvkI-1ve5A:
2.3		 3nvkI-1ve5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 8 LEU A 182
ARG A  53
ALA A  52
GLY A 280
PRO A 176
 PLP  A 413 (-4.5A)
None
None
None
PLP  A 413 (-4.4A)
 1.47A 3ny4A-1ve5A:
undetectable		 3ny4A-1ve5A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 8 THR A 242
GLY A 179
GLY A 178
VAL A 177
 None
PLP  A 413 (-3.6A)
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.4A)
 0.84A 4qvvK-1ve5A:
undetectable
4qvvL-1ve5A:
undetectable		 4qvvK-1ve5A:
21.41
4qvvL-1ve5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 8 THR A 242
GLY A 179
GLY A 178
VAL A 177
 None
PLP  A 413 (-3.6A)
PLP  A 413 (-3.3A)
PLP  A 413 ( 4.4A)
 0.84A 4qvvY-1ve5A:
undetectable
4qvvZ-1ve5A:
undetectable		 4qvvY-1ve5A:
21.41
4qvvZ-1ve5A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 12 LEU A 182
GLY A  48
LEU A  44
LYS A  51
ASN A  75
 PLP  A 413 (-4.5A)
None
None
PLP  A 413 (-1.3A)
PLP  A 413 (-3.9A)
 1.40A 5emlA-1ve5A:
2.7		 5emlA-1ve5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 7 GLY A  74
VAL A 114
ASP A 116
VAL A  93
 None
 0.81A 5ik1A-1ve5A:
undetectable		 5ik1A-1ve5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		3 / 3 VAL A 199
ARG A 241
PRO A 244
 None
 0.86A 5koxA-1ve5A:
undetectable		 5koxA-1ve5A:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		5 / 7 GLY A 151
GLY A  54
SER A 303
THR A 154
ALA A 155
 None
None
PLP  A 413 (-2.8A)
None
None
 1.37A 5o96C-1ve5A:
2.2		 5o96C-1ve5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		3 / 3 ARG A 218
ARG A 212
ARG A 221
 None
 0.66A 5vcgA-1ve5A:
undetectable		 5vcgA-1ve5A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 1ve5 THREONINE DEAMINASE
(Thermus
thermophilus) 		4 / 4 PRO A 226
LEU A 222
VAL A 233
ARG A 234
 None
 1.43A 6fgdA-1ve5A:
2.8		 6fgdA-1ve5A:
23.29