SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		3 / 3 PHE A 269
LEU A 126
LEU A 264
 None
 0.65A 1mx1E-1vecA:
undetectable		 1mx1E-1vecA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		5 / 12 ILE A 232
ILE A 215
ILE A 248
LEU A 254
VAL A 229
 None
 1.20A 3fpjB-1vecA:
4.2		 3fpjB-1vecA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		4 / 4 SER A 170
ASP A 197
ASP A 217
ALA A 210
 None
 1.45A 3uj6A-1vecA:
3.5		 3uj6A-1vecA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		3 / 3 LYS A 239
LYS A 135
ALA A 267
 None
 1.35A 4ot2A-1vecA:
undetectable		 4ot2A-1vecA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		4 / 5 LEU A 140
ALA A 156
VAL A 160
ILE A 159
 None
 0.89A 4xe3A-1vecA:
undetectable		 4xe3A-1vecA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		4 / 5 LEU A 140
ALA A 156
VAL A 160
ILE A 159
 None
 0.95A 4xe3B-1vecA:
undetectable		 4xe3B-1vecA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		4 / 4 LEU A 126
ARG A 123
ILE A 125
ILE A 118
 None
 1.22A 5dzk2-1vecA:
undetectable
5dzkM-1vecA:
undetectable
5dzkN-1vecA:
undetectable		 5dzk2-1vecA:
13.33
5dzkM-1vecA:
21.55
5dzkN-1vecA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		3 / 3 GLY A 132
GLN A 168
LYS A 135
 None
 0.57A 5imsB-1vecA:
3.5		 5imsB-1vecA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		4 / 5 TYR A 139
GLU A 236
GLY A 132
SER A 136
 None
 1.32A 5jhdJ-1vecA:
0.0		 5jhdJ-1vecA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens) 		4 / 4 PRO A 142
MET A 180
GLY A 182
VAL A 176
 None
 1.50A 6ak3A-1vecA:
undetectable		 6ak3A-1vecA:
18.85