SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ARG A 212
PHE A 240
LEU A 222
PRO A 247
LEU A 104
 None
 1.14A 1og5B-1vefA:
undetectable		 1og5B-1vefA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 LYS A 218
GLU A 217
ALA A 220
VAL A 189
 None
 0.94A 1sn5A-1vefA:
undetectable		 1sn5A-1vefA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ALA A 120
THR A 251
PHE A 133
 None
 0.67A 2c6nB-1vefA:
undetectable		 2c6nB-1vefA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 PHE A 108
ARG A  89
GLY A 281
THR A 282
 None
 1.22A 2f7fA-1vefA:
undetectable		 2f7fA-1vefA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A 376
ARG A 303
GLU A 241
ARG A 237
 None
 1.06A 2jn3A-1vefA:
undetectable		 2jn3A-1vefA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LEU A 100
PRO A 101
LEU A 104
 None
 0.44A 2qd5B-1vefA:
2.3		 2qd5B-1vefA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 MET A  88
LEU A 262
ASN A 287
THR A  95
 None
 1.45A 2qk8A-1vefA:
1.4		 2qk8A-1vefA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 PHE A 372
LEU A 394
ALA A 389
ALA A 362
 None
 0.85A 2vcvB-1vefA:
undetectable		 2vcvB-1vefA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 PHE A 372
LEU A 394
ALA A 389
ALA A 362
 None
 0.78A 2vcvK-1vefA:
undetectable		 2vcvK-1vefA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A600_1
(ORF12)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 THR A 144
SER A 147
ALA A 116
GLY A 113
SER A 112
 None
None
None
PLP  A 513 (-3.2A)
PLP  A 513 ( 4.0A)
 1.13A 2xf3A-1vefA:
undetectable		 2xf3A-1vefA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B600_1
(ORF12)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 THR A 144
SER A 147
ALA A 116
GLY A 113
SER A 112
 None
None
None
PLP  A 513 (-3.2A)
PLP  A 513 ( 4.0A)
 1.14A 2xf3B-1vefA:
undetectable		 2xf3B-1vefA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 TYR A  54
ASN A  25
GLU A  16
VAL A  51
LEU A 361
 None
 1.37A 3cb8A-1vefA:
1.5		 3cb8A-1vefA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 THR A 114
SER A 112
PHE A 108
 PLP  A 513 (-3.8A)
PLP  A 513 ( 4.0A)
None
 0.90A 3d4sA-1vefA:
undetectable		 3d4sA-1vefA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 TYR A 156
GLY A 198
THR A 151
GLU A 226
 None
 1.05A 3fpjA-1vefA:
2.9		 3fpjA-1vefA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 SER A 112
GLY A 113
THR A 114
 PLP  A 513 ( 4.0A)
PLP  A 513 (-3.2A)
PLP  A 513 (-3.8A)
 0.21A 3k9wA-1vefA:
undetectable		 3k9wA-1vefA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 376
GLY A  60
HIS A  61
ALA A 293
ASN A  58
 None
 1.25A 3tm4A-1vefA:
2.9		 3tm4A-1vefA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 PRO A 193
LEU A 208
ILE A 245
ARG A 212
 None
 1.34A 3w1wA-1vefA:
undetectable		 3w1wA-1vefA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LEU A 100
PRO A 101
LEU A 104
 None
 0.47A 3w1wB-1vefA:
2.9		 3w1wB-1vefA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 VAL A 189
LEU A 191
ALA A 211
THR A 215
VAL A 182
 None
 1.13A 4e0fA-1vefA:
undetectable		 4e0fA-1vefA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 GLU A 342
ARG A 322
GLY A 334
ARG A 333
 None
 1.03A 4fgzA-1vefA:
undetectable
4fgzB-1vefA:
undetectable		 4fgzA-1vefA:
20.83
4fgzB-1vefA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 257
GLY A 294
ALA A  69
ASN A 287
GLY A 286
 None
 0.95A 4n09D-1vefA:
3.2		 4n09D-1vefA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 GLU A 192
ARG A 333
GLY A 199
GLY A 196
 PLP  A 513 (-3.9A)
None
None
None
 0.84A 4rdxA-1vefA:
undetectable		 4rdxA-1vefA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 GLY A 366
GLY A 199
THR A 368
ALA A 347
 None
 0.69A 5o96C-1vefA:
undetectable		 5o96C-1vefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 MET A 231
ALA A 255
LEU A 306
ARG A 303
VAL A  66
 None
 1.27A 5vlmD-1vefA:
undetectable		 5vlmD-1vefA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 MET A 231
ALA A 255
LEU A 306
ARG A 303
VAL A  66
 None
 1.35A 5vlmE-1vefA:
undetectable		 5vlmE-1vefA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 VAL A 175
LEU A 178
LEU A 191
GLN A 195
THR A 204
 None
 1.28A 6czmA-1vefA:
undetectable
6czmB-1vefA:
undetectable		 6czmA-1vefA:
22.71
6czmB-1vefA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 VAL A 175
LEU A 178
LEU A 191
GLN A 195
THR A 204
 None
 1.26A 6czmB-1vefA:
undetectable
6czmC-1vefA:
undetectable		 6czmB-1vefA:
22.71
6czmC-1vefA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 LEU A 191
GLN A 195
THR A 204
VAL A 175
LEU A 178
 None
 1.22A 6czmD-1vefA:
undetectable
6czmF-1vefA:
undetectable		 6czmD-1vefA:
22.71
6czmF-1vefA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 VAL A  39
GLU A  46
ILE A  31
 None
 0.61A 6f7lB-1vefA:
undetectable		 6f7lB-1vefA:
23.82