SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1vfd LACTOFERRIN
(Homo
sapiens) 		4 / 7 ILE A  49
LEU A  59
ILE A 267
ASP A  55
 None
 0.96A 1yc2E-1vfdA:
undetectable		 1yc2E-1vfdA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1vfd LACTOFERRIN
(Homo
sapiens) 		4 / 8 SER A 252
TYR A  92
TYR A 192
HIS A 253
 None
FE  A 400 (-4.1A)
CO3  A 401 (-3.8A)
FE  A 400 (-3.1A)
 1.35A 2bteA-1vfdA:
undetectable		 2bteA-1vfdA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1vfd LACTOFERRIN
(Homo
sapiens) 		4 / 8 SER A 252
TYR A  92
TYR A 192
HIS A 253
 None
FE  A 400 (-4.1A)
CO3  A 401 (-3.8A)
FE  A 400 (-3.1A)
 1.29A 2v0gA-1vfdA:
undetectable		 2v0gA-1vfdA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1vfd LACTOFERRIN
(Homo
sapiens) 		3 / 3 TYR A 192
GLU A 121
THR A  58
 CO3  A 401 (-3.8A)
CO3  A 401 ( 3.7A)
None
 0.98A 2y7hB-1vfdA:
undetectable		 2y7hB-1vfdA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 1vfd LACTOFERRIN
(Homo
sapiens) 		3 / 3 ASP A  55
ASN A  52
SER A   5
 None
 0.90A 3lslA-1vfdA:
5.3
3lslD-1vfdA:
5.9		 3lslA-1vfdA:
21.30
3lslD-1vfdA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 1vfd LACTOFERRIN
(Homo
sapiens) 		3 / 3 PRO A 251
TYR A 319
GLY A 321
 None
 0.39A 4g2zA-1vfdA:
39.4		 4g2zA-1vfdA:
41.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 1vfd LACTOFERRIN
(Homo
sapiens) 		5 / 12 GLY A 124
GLY A 118
ILE A 209
ALA A 195
ALA A  94
 CO3  A 401 (-4.5A)
None
None
None
None
 1.18A 4kicA-1vfdA:
undetectable		 4kicA-1vfdA:
24.21