SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 ASN A  24
ILE A  20
SER A  70
THR A 113
 None
 1.24A 1h7xB-1vffA:
6.4		 1h7xB-1vffA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 ASN A  24
ILE A  20
SER A  70
THR A 113
 None
 1.27A 1h7xC-1vffA:
2.9		 1h7xC-1vffA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 ASN A  24
ILE A  20
SER A  70
THR A 113
 None
 1.27A 1h7xD-1vffA:
6.2		 1h7xD-1vffA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 TYR A 361
TRP A 362
GLY A 373
TRP A 169
 None
 1.26A 1mxgA-1vffA:
6.7		 1mxgA-1vffA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 138
VAL A 140
ALA A 191
PHE A 153
PHE A 124
 None
 1.32A 1nw3A-1vffA:
undetectable		 1nw3A-1vffA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 PHE A 118
ARG A  75
ASN A  27
 None
 0.93A 1xzxX-1vffA:
undetectable		 1xzxX-1vffA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 294
ASP A 221
ASP A 289
 None
 0.87A 2br4D-1vffA:
undetectable		 2br4D-1vffA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 5 TYR A 359
TYR A 399
ILE A 402
GLY A 358
 None
 1.33A 2du8J-1vffA:
undetectable		 2du8J-1vffA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		5 / 11 ASN A 154
GLU A 155
TYR A 267
GLU A 324
TRP A 362
 None
 0.85A 2v3dB-1vffA:
16.0		 2v3dB-1vffA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 TYR A 399
ALA A  14
LEU A 106
ALA A  66
 None
 1.12A 2vcvA-1vffA:
0.0		 2vcvA-1vffA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 TRP A 299
THR A 268
VAL A 285
PHE A 232
ASN A 233
 None
 1.46A 2y03B-1vffA:
undetectable		 2y03B-1vffA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 151
ILE A 209
PRO A 210
ILE A 262
THR A 152
 None
 1.17A 3clbD-1vffA:
undetectable		 3clbD-1vffA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 310
VAL A 206
GLY A 263
THR A 323
LEU A 106
 None
 0.88A 3dh0A-1vffA:
undetectable		 3dh0A-1vffA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 PHE A 364
ILE A 339
TYR A 399
GLY A  12
 None
 0.99A 3gssA-1vffA:
undetectable		 3gssA-1vffA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 151
ILE A 209
PRO A 210
ILE A 262
THR A 152
 None
 1.18A 3hbbD-1vffA:
undetectable		 3hbbD-1vffA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 372
GLU A 369
TRP A 299
 None
 0.83A 3hrdA-1vffA:
undetectable
3hrdE-1vffA:
undetectable
3hrdF-1vffA:
undetectable		 3hrdA-1vffA:
20.88
3hrdE-1vffA:
20.88
3hrdF-1vffA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 6 GLU A 271
ASP A 221
ASP A 217
LYS A 218
 None
 1.30A 3pocB-1vffA:
8.2		 3pocB-1vffA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A  66
ASN A 265
ILE A 322
GLU A 324
THR A  15
 None
 1.09A 3rukC-1vffA:
0.0		 3rukC-1vffA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 THR A 268
TRP A 299
HIS A 342
ASN A 325
 None
 1.45A 4a3uA-1vffA:
12.5		 4a3uA-1vffA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 THR A 268
TRP A 299
HIS A 342
ASN A 325
 None
 1.39A 4a3uB-1vffA:
13.5		 4a3uB-1vffA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 379
VAL A 346
TYR A 359
ASN A 325
HIS A 342
 None
 1.42A 4ffwA-1vffA:
undetectable		 4ffwA-1vffA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 324
TRP A 362
LYS A 207
 None
 1.37A 4k7aA-1vffA:
undetectable		 4k7aA-1vffA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		3 / 3 ASN A 154
PHE A 360
TYR A  67
 None
 0.70A 4u15A-1vffA:
undetectable		 4u15A-1vffA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 322
LEU A 320
ALA A 309
ILE A 306
 None
 0.74A 4y03A-1vffA:
undetectable		 4y03A-1vffA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 PRO A 170
THR A 113
TYR A  32
TRP A 362
 None
 1.12A 5x2sI-1vffA:
undetectable
5x2sJ-1vffA:
undetectable
5x2sK-1vffA:
undetectable		 5x2sI-1vffA:
16.14
5x2sJ-1vffA:
17.75
5x2sK-1vffA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1vff BETA-GLUCOSIDASE
(Pyrococcus
horikoshii) 		4 / 8 GLU A  21
PHE A 118
MET A 119
LEU A 130
 None
 1.01A 5y2tB-1vffA:
undetectable		 5y2tB-1vffA:
undetectable