SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vfg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 PHE A 106
ASN A 109
PHE A 159
 None
 1.02A 2zbuD-1vfgA:
undetectable		 2zbuD-1vfgA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 GLU A 252
HIS A 245
THR A 322
 None
 0.86A 3hkuA-1vfgA:
undetectable		 3hkuA-1vfgA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 GLU A  81
ASP A 100
ASP A 105
 None
None
APC  A 500 (-3.6A)
 0.60A 3jb2A-1vfgA:
undetectable		 3jb2A-1vfgA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 221
LEU A 154
ALA A 199
MET A 280
 None
 0.86A 3r9tB-1vfgA:
undetectable		 3r9tB-1vfgA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 213
ARG A 216
TRP A 227
 None
 1.11A 4b7nA-1vfgA:
undetectable		 4b7nA-1vfgA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 213
ARG A 216
TRP A 227
 None
 1.05A 4cpzC-1vfgA:
undetectable		 4cpzC-1vfgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 213
ARG A 216
TRP A 227
 None
 1.04A 4cpzE-1vfgA:
undetectable		 4cpzE-1vfgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 213
ARG A 216
TRP A 227
 None
 1.07A 4cpzF-1vfgA:
undetectable		 4cpzF-1vfgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 213
ARG A 216
TRP A 227
 None
 1.04A 4cpzG-1vfgA:
undetectable		 4cpzG-1vfgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 213
ARG A 216
TRP A 227
 None
 1.04A 4cpzH-1vfgA:
undetectable		 4cpzH-1vfgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 8 GLU A 172
ALA A 156
LEU A 154
VAL A 140
 None
 0.98A 4ik6B-1vfgA:
undetectable		 4ik6B-1vfgA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 7 LEU A 154
VAL A 151
PRO A 150
TYR A 215
 None
 1.07A 4lb2A-1vfgA:
0.4		 4lb2A-1vfgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 6 TYR A 341
GLU A 252
THR A 322
LEU A 345
 None
 1.30A 4qzuC-1vfgA:
undetectable		 4qzuC-1vfgA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 10 PHE A 276
LEU A 209
LEU A 261
LEU A 264
PHE A 225
 None
 1.34A 4zmeB-1vfgA:
undetectable		 4zmeB-1vfgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 4 VAL A  35
ILE A  15
ASN A 116
VAL A   2
 None
 1.33A 5ajqA-1vfgA:
undetectable		 5ajqA-1vfgA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 PHE A 276
LEU A 218
ILE A 153
ALA A 199
LEU A 157
 None
 1.35A 5ienA-1vfgA:
undetectable		 5ienA-1vfgA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 304
ILE A 338
ILE A 254
TYR A 256
LEU A 259
 None
 1.06A 5y2tB-1vfgA:
undetectable		 5y2tB-1vfgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1vfg POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ASP A 100
ARG A  79
ASP A  33
 None
None
APC  A 500 ( 4.8A)
 0.89A 5zvgB-1vfgA:
undetectable		 5zvgB-1vfgA:
24.71