SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		3 / 3 TRP A  84
VAL A 102
TRP A 166
 DCS  A 401 ( 3.9A)
None
KCX  A 129 ( 3.4A)
 0.83A 1c4dA-1vftA:
undetectable
1c4dB-1vftA:
undetectable		 1c4dA-1vftA:
11.20
1c4dB-1vftA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 7 HIS A  44
GLY A  43
ALA A  41
TYR A  42
 None
None
None
DCS  A 401 (-4.6A)
 0.83A 1dmaA-1vftA:
undetectable		 1dmaA-1vftA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		5 / 12 VAL A 303
ILE A 338
ILE A 293
ILE A 316
VAL A 323
 None
 0.98A 1qhsA-1vftA:
undetectable		 1qhsA-1vftA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		5 / 12 VAL A 303
ILE A 338
ILE A 293
ILE A 316
VAL A 323
 None
 0.97A 1qhyA-1vftA:
undetectable		 1qhyA-1vftA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		6 / 12 ASP A  13
ALA A 249
GLY A 378
LEU A 379
CYH A  49
TYR A 375
 None
 1.43A 1rjdA-1vftA:
undetectable		 1rjdA-1vftA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		6 / 12 ASP A  13
ALA A 249
GLY A 378
LEU A 379
CYH A  49
TYR A 375
 None
 1.46A 1rjdB-1vftA:
undetectable		 1rjdB-1vftA:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 8 LYS A  38
TYR A  42
ARG A 136
TYR A 361
 DCS  A 401 (-2.8A)
DCS  A 401 (-4.6A)
KCX  A 129 (-3.9A)
DCS  A 401 (-4.5A)
 0.45A 1xqlA-1vftA:
43.0
1xqlB-1vftA:
42.9		 1xqlA-1vftA:
35.38
1xqlB-1vftA:
35.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 8 LYS A  38
TYR A  42
ARG A 136
TYR A 361
 DCS  A 401 (-2.8A)
DCS  A 401 (-4.6A)
KCX  A 129 (-3.9A)
DCS  A 401 (-4.5A)
 0.46A 1xqlA-1vftA:
43.0
1xqlB-1vftA:
42.9		 1xqlA-1vftA:
35.38
1xqlB-1vftA:
35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 7 PRO A 234
LEU A 244
GLY A 245
LEU A 213
 None
 0.90A 1ya4B-1vftA:
undetectable		 1ya4B-1vftA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		3 / 3 THR A 212
PRO A 210
THR A 214
 None
DCS  A 401 (-4.9A)
None
 0.78A 209dC-1vftA:
undetectable		 209dC-1vftA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		5 / 12 VAL A 259
LEU A 256
VAL A 285
VAL A 303
ARG A 310
 None
 1.12A 2cbrA-1vftA:
undetectable		 2cbrA-1vftA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		3 / 3 VAL A 102
VAL A 104
TRP A  86
 None
 0.91A 3l8lA-1vftA:
undetectable
3l8lB-1vftA:
undetectable		 3l8lA-1vftA:
11.20
3l8lB-1vftA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		5 / 11 VAL A 104
ILE A  96
ALA A 154
ALA A 117
THR A 159
 None
 1.07A 3mdtB-1vftA:
undetectable		 3mdtB-1vftA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 8 LEU A 222
ALA A 211
THR A 212
GLY A  62
 None
 0.92A 3ny4A-1vftA:
undetectable		 3ny4A-1vftA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 7 ARG A 373
ALA A  10
VAL A   8
LEU A 252
 None
 0.79A 3o14A-1vftA:
undetectable		 3o14A-1vftA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		5 / 9 GLY A 340
ASP A  13
ILE A  12
GLY A 231
ILE A 367
 None
 1.01A 3s53A-1vftA:
undetectable		 3s53A-1vftA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 6 ILE A 206
ILE A  81
TRP A  60
TRP A  84
 None
None
None
DCS  A 401 ( 3.9A)
 1.44A 3weoA-1vftA:
2.9		 3weoA-1vftA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 6 HIS A  44
GLY A  43
ALA A  41
TYR A  42
 None
None
None
DCS  A 401 (-4.6A)
 0.99A 4ae1A-1vftA:
undetectable		 4ae1A-1vftA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 4 LEU A 134
ILE A 206
GLY A 133
PHE A 169
 KCX  A 129 ( 4.4A)
None
None
None
 1.12A 4dc3A-1vftA:
undetectable		 4dc3A-1vftA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 6 PHE A 169
ALA A 172
PRO A 216
THR A 214
 None
 1.06A 4dtzB-1vftA:
undetectable		 4dtzB-1vftA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 8 ALA A 228
SER A 233
LEU A 213
TYR A 361
 None
None
None
DCS  A 401 (-4.5A)
 0.98A 4ijiF-1vftA:
undetectable		 4ijiF-1vftA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 8 ILE A 293
ILE A 367
ALA A  10
VAL A 303
 None
 0.70A 4jltA-1vftA:
undetectable		 4jltA-1vftA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		3 / 3 GLU A 327
THR A 261
HIS A 281
 None
 0.87A 4q15A-1vftA:
undetectable		 4q15A-1vftA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		5 / 12 ALA A 356
GLY A 301
ALA A 290
GLY A 292
GLU A 362
 None
 1.19A 4r29C-1vftA:
undetectable		 4r29C-1vftA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 6 GLY A 340
GLU A 346
ASP A 351
ASP A 341
 None
 1.05A 4uckB-1vftA:
undetectable		 4uckB-1vftA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		3 / 3 GLU A 327
THR A 261
HIS A 281
 None
 0.82A 4ydqB-1vftA:
undetectable		 4ydqB-1vftA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		4 / 7 LEU A 238
THR A 214
PRO A 175
ILE A 180
 None
 1.06A 5fxtA-1vftA:
undetectable		 5fxtA-1vftA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		3 / 3 ARG A  80
ARG A 122
ARG A  73
 None
 0.80A 6bplA-1vftA:
undetectable
6bplB-1vftA:
undetectable		 6bplA-1vftA:
12.63
6bplB-1vftA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1vft ALANINE RACEMASE
(Streptomyces
lavendulae) 		5 / 11 VAL A 102
TRP A  92
TRP A 108
THR A 159
ALA A 124
 None
 1.50A 6dk1C-1vftA:
0.1		 6dk1C-1vftA:
20.73