SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		4 / 4 ILE A 119
LEU A 158
VAL A 144
ILE A 192
 None
 0.75A 1fm6D-1vfwA:
0.0		 1fm6D-1vfwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		4 / 6 LEU A 246
LYS A 243
ILE A 224
ARG A 169
 None
 1.08A 1opjB-1vfwA:
undetectable		 1opjB-1vfwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		5 / 12 MET A  81
ALA A 326
LYS A   7
ALA A   9
ILE A  93
 None
 1.13A 3ut5D-1vfwA:
undetectable		 3ut5D-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		5 / 12 ARG A  11
ALA A 326
ILE A 119
VAL A  73
ILE A  77
 ANP  A 500 (-3.7A)
None
None
None
None
 0.94A 4dqbA-1vfwA:
undetectable		 4dqbA-1vfwA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		3 / 3 HIS A 218
VAL A 178
LEU A 314
 None
 0.77A 4m2vA-1vfwA:
undetectable		 4m2vA-1vfwA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		5 / 12 MET A  81
ALA A 326
VAL A 328
LYS A   7
ALA A   9
 None
 1.15A 4x1iB-1vfwA:
undetectable		 4x1iB-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		5 / 12 MET A  81
ALA A 326
LYS A   7
ALA A   9
ILE A  93
 None
 1.11A 4x1iD-1vfwA:
undetectable		 4x1iD-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		6 / 12 MET A  81
ALA A 326
VAL A 328
LYS A   7
ALA A   9
ILE A  93
 None
 1.04A 4x1kD-1vfwA:
undetectable		 4x1kD-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		6 / 12 MET A  81
ALA A 326
VAL A 328
LYS A   7
ALA A   9
ILE A  93
 None
 1.07A 4x1yD-1vfwA:
undetectable		 4x1yD-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		5 / 11 MET A  81
ALA A 326
VAL A 328
LYS A   7
ILE A  93
 None
 1.10A 4x20D-1vfwA:
undetectable		 4x20D-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		5 / 12 ILE A 354
VAL A   8
ALA A 330
ALA A 329
GLY A 251
 None
None
None
None
ANP  A 500 (-3.4A)
 1.02A 5igjA-1vfwA:
undetectable		 5igjA-1vfwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		5 / 12 ILE A 354
VAL A   8
ALA A 330
ALA A 329
GLY A 251
 None
None
None
None
ANP  A 500 (-3.4A)
 1.00A 5igtA-1vfwA:
undetectable		 5igtA-1vfwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG
(Mus
musculus) 		4 / 7 TYR A 347
TYR A  96
GLN A 353
ASP A 349
 None
 1.44A 5ov9B-1vfwA:
undetectable		 5ov9B-1vfwA:
21.00