SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vg0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 8 CYH A 385
HIS A  36
GLY A  17
GLY A  44
 None
 0.87A 1ekjA-1vg0A:
undetectable
1ekjB-1vg0A:
undetectable		 1ekjA-1vg0A:
17.00
1ekjB-1vg0A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 7 CYH A 385
HIS A  36
GLY A  17
GLY A  44
 None
 0.81A 1ekjE-1vg0A:
undetectable
1ekjF-1vg0A:
undetectable		 1ekjE-1vg0A:
17.00
1ekjF-1vg0A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 8 CYH A 385
HIS A  36
GLY A  17
GLY A  44
 None
 0.81A 1ekjG-1vg0A:
undetectable
1ekjH-1vg0A:
undetectable		 1ekjG-1vg0A:
17.00
1ekjH-1vg0A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 11 GLY A 574
PRO A 575
GLU A 432
GLY A  15
ASP A  38
 None
 1.26A 1jzsA-1vg0A:
undetectable		 1jzsA-1vg0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		3 / 3 THR A 285
LEU A 284
VAL A 278
 None
 0.60A 1mz9E-1vg0A:
undetectable		 1mz9E-1vg0A:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 8 LEU A 321
TYR A 320
LEU A 296
LEU A 359
 None
None
GER  A 952 ( 4.9A)
GER  A 952 ( 4.8A)
 0.94A 2bfpC-1vg0A:
4.0		 2bfpC-1vg0A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 10 ILE A 338
ALA A 339
ILE A 471
PRO A 272
ILE A 260
 None
None
None
GER  A 952 (-4.2A)
None
 1.25A 2dm6A-1vg0A:
undetectable
2dm6B-1vg0A:
undetectable		 2dm6A-1vg0A:
19.40
2dm6B-1vg0A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 LEU A 380
LEU A 238
GLY A 237
VAL A 585
ALA A 584
 None
 1.23A 2kceB-1vg0A:
undetectable		 2kceB-1vg0A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		3 / 3 ARG A  40
ASP A 433
ASN A  46
 None
 0.60A 2zzmA-1vg0A:
undetectable		 2zzmA-1vg0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 5 ILE A 240
SER A 235
PHE A 370
PRO A 369
 None
 1.36A 3bjwC-1vg0A:
undetectable		 3bjwC-1vg0A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		3 / 3 PRO A 475
PHE A 317
LYS A 343
 None
 1.24A 3bjwG-1vg0A:
undetectable		 3bjwG-1vg0A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 8 ASP A  38
SER A  39
ASP A  92
ASP A 433
 None
 1.25A 3havA-1vg0A:
undetectable		 3havA-1vg0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		3 / 3 ARG A 485
ASP A 553
GLN A 587
 None
 0.91A 3lcvB-1vg0A:
undetectable		 3lcvB-1vg0A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 LEU A 404
ALA A  85
GLU A  84
ARG A 411
ILE A 431
 None
 1.17A 3olsB-1vg0A:
undetectable		 3olsB-1vg0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 7 LEU A 517
ASP A 516
SER A 450
GLU A 343
 None
 1.31A 4aq7A-1vg0A:
2.4		 4aq7A-1vg0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 MET A 551
PHE A 549
ASP A  92
ASP A  38
GLY A  44
 None
 1.24A 4djeA-1vg0A:
undetectable		 4djeA-1vg0A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 MET A 551
PHE A 549
ASP A  92
ASP A  38
GLY A  44
 None
 1.19A 4djeB-1vg0A:
undetectable		 4djeB-1vg0A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 8 PHE A 370
ILE A 487
GLY A 578
ASN A 581
 None
 0.88A 4fgjA-1vg0A:
2.1
4fgjB-1vg0A:
undetectable		 4fgjA-1vg0A:
19.38
4fgjB-1vg0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		3 / 3 ASP A 433
ASN A  46
SER A 437
 None
 0.80A 4obwA-1vg0A:
undetectable		 4obwA-1vg0A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 LEU A  55
VAL A  98
LEU A 547
PHE A 549
MET A 551
 None
 0.94A 4y0sA-1vg0A:
undetectable		 4y0sA-1vg0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 VAL A 271
ALA A 262
PHE A 370
ILE A 471
THR A 473
 GER  A 952 ( 4.8A)
None
None
None
None
 0.74A 5hieB-1vg0A:
undetectable		 5hieB-1vg0A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 ALA A 339
PHE A 358
THR A 355
PHE A 317
LEU A 321
 None
 1.09A 5k9dA-1vg0A:
0.0		 5k9dA-1vg0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 4 THR A 456
ASP A 457
ARG A 542
LEU A 543
 None
 1.43A 5tdmA-1vg0A:
0.3		 5tdmA-1vg0A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 VAL A 390
PRO A 606
TYR A 251
ALA A 389
GLY A 392
 None
 1.36A 5tzoA-1vg0A:
undetectable		 5tzoA-1vg0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		5 / 12 VAL A 390
PRO A 606
TYR A 251
ALA A 389
GLY A 392
 None
 1.35A 5tzoC-1vg0A:
undetectable		 5tzoC-1vg0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		6 / 12 PRO A 575
GLY A  45
SER A 573
LEU A  18
GLY A  17
PRO A  19
 None
 1.45A 5zhmB-1vg0A:
undetectable		 5zhmB-1vg0A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 7 ASP A 277
GLN A 270
GLY A 363
SER A 274
 None
 0.97A 6ekzA-1vg0A:
undetectable		 6ekzA-1vg0A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 6 ASP A  92
TYR A 435
GLU A 432
ASP A 433
 None
 1.49A 6mn5A-1vg0A:
0.1		 6mn5A-1vg0A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1
(Rattus
norvegicus) 		4 / 6 ASP A  92
TYR A 435
GLU A 432
ASP A 433
 None
 1.37A 6mn5C-1vg0A:
undetectable		 6mn5C-1vg0A:
9.05