SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vgm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 10 HIS A 219
ALA A 223
THR A 313
HIS A 184
ALA A 222
SO4  A 411 ( 3.8A)
GOL  A 401 (-3.1A)
None
None
GOL  A 401 (-3.2A)
1.46A 1gtnO-1vgmA:
undetectable
1gtnP-1vgmA:
undetectable
1gtnO-1vgmA:
11.76
1gtnP-1vgmA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 8 LEU A  19
LEU A  48
TYR A  45
SER A 338
None
1.24A 1hk2A-1vgmA:
0.1
1hk2A-1vgmA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
3 / 3 HIS A 184
ASP A  35
ASN A  41
None
0.72A 1wg8B-1vgmA:
undetectable
1wg8B-1vgmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 6 LEU A  19
LEU A  39
LEU A 341
ILE A  36
None
1.00A 1z95A-1vgmA:
undetectable
1z95A-1vgmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 6 ALA A 223
ASP A 314
GLU A 224
MET A 174
GOL  A 401 (-3.1A)
GOL  A 401 ( 4.5A)
GOL  A 401 (-4.2A)
None
1.45A 2ouzA-1vgmA:
undetectable
2ouzA-1vgmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 12 ILE A 347
ALA A 210
THR A 128
LEU A 344
LEU A 104
None
1.16A 2rctA-1vgmA:
undetectable
2rctA-1vgmA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 10 ILE A 135
ALA A 133
ILE A 207
LEU A 211
THR A 161
None
1.25A 2w3aB-1vgmA:
undetectable
2w3aB-1vgmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 12 ILE A  69
ALA A 121
LEU A 341
GLN A  62
LEU A  63
None
0.99A 2w3mB-1vgmA:
undetectable
2w3mB-1vgmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 9 GLY A 318
ILE A 233
PHE A 315
GLY A 256
PHE A 257
None
1.35A 3ko0A-1vgmA:
0.4
3ko0C-1vgmA:
0.3
3ko0A-1vgmA:
13.14
3ko0C-1vgmA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 9 GLY A 318
ILE A 292
PHE A 315
GLY A 256
PHE A 257
None
1.42A 3ko0A-1vgmA:
0.4
3ko0C-1vgmA:
0.3
3ko0A-1vgmA:
13.14
3ko0C-1vgmA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 10 GLY A 318
ILE A 233
PHE A 315
GLY A 256
PHE A 257
None
1.34A 3ko0R-1vgmA:
0.2
3ko0T-1vgmA:
undetectable
3ko0R-1vgmA:
13.14
3ko0T-1vgmA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 10 GLY A 318
ILE A 292
PHE A 315
GLY A 256
PHE A 257
None
1.44A 3ko0R-1vgmA:
0.2
3ko0T-1vgmA:
undetectable
3ko0R-1vgmA:
13.14
3ko0T-1vgmA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 9 THR A 191
ALA A 192
LEU A 194
ALA A 196
SER A 197
None
1.45A 3kp6B-1vgmA:
undetectable
3kp6B-1vgmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 9 ILE A 171
ALA A 159
LEU A 158
LEU A 178
ALA A 176
None
1.02A 3ozvB-1vgmA:
undetectable
3ozvB-1vgmA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 8 ILE A 207
VAL A 340
THR A 128
ILE A 131
None
0.81A 3p4wC-1vgmA:
undetectable
3p4wC-1vgmA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 8 ASP A 109
ALA A 105
SER A 205
SER A 201
None
0.99A 3rodA-1vgmA:
undetectable
3rodA-1vgmA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 6 LEU A 158
PHE A 326
THR A 132
LEU A 178
None
0.71A 3t3zA-1vgmA:
undetectable
3t3zA-1vgmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 6 LEU A 158
PHE A 326
THR A 132
LEU A 178
None
0.76A 3t3zB-1vgmA:
undetectable
3t3zB-1vgmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 6 LEU A 158
PHE A 326
THR A 132
LEU A 178
None
0.76A 3t3zD-1vgmA:
undetectable
3t3zD-1vgmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 12 THR A 313
GLY A 256
GLY A 258
HIS A 259
PHE A 272
None
1.05A 3tkaA-1vgmA:
undetectable
3tkaA-1vgmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 7 TYR A 310
ASP A 314
GLY A 256
PHE A 257
None
GOL  A 401 ( 4.5A)
None
None
0.77A 4iqqA-1vgmA:
undetectable
4iqqA-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 7 TYR A 310
ASP A 314
GLY A 256
PHE A 257
None
GOL  A 401 ( 4.5A)
None
None
0.77A 4iqqB-1vgmA:
undetectable
4iqqB-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 7 TYR A 310
ASP A 314
GLY A 256
PHE A 257
None
GOL  A 401 ( 4.5A)
None
None
0.81A 4iqqC-1vgmA:
undetectable
4iqqC-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 8 TYR A 310
ASP A 314
GLY A 256
PHE A 257
None
GOL  A 401 ( 4.5A)
None
None
0.77A 4iqqD-1vgmA:
undetectable
4iqqD-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB305_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 4 SER A 306
THR A 303
PHE A 304
LYS A 307
None
1.47A 4m93B-1vgmA:
undetectable
4m93B-1vgmA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 7 LEU A  19
LEU A  39
LEU A 341
ILE A  36
None
1.04A 4okwA-1vgmA:
undetectable
4okwA-1vgmA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 8 ILE A  69
LEU A 104
VAL A 340
LEU A 344
ILE A 207
None
1.44A 4r38D-1vgmA:
undetectable
4r38D-1vgmA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 8 ALA A  93
ILE A  94
GLU A 224
PHE A 335
LEU A 214
None
None
GOL  A 401 (-4.2A)
GOL  A 401 (-3.6A)
None
1.41A 4v1fA-1vgmA:
undetectable
4v1fB-1vgmA:
undetectable
4v1fA-1vgmA:
13.23
4v1fB-1vgmA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 8 ILE A  69
SER A 156
LEU A 178
ILE A 125
None
0.99A 4xtaB-1vgmA:
undetectable
4xtaB-1vgmA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
3 / 3 ASN A 134
LEU A 104
PHE A  74
None
0.73A 5dsgA-1vgmA:
2.4
5dsgA-1vgmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 8 ILE A 207
VAL A 340
THR A 128
ILE A 131
None
0.88A 5mzrE-1vgmA:
undetectable
5mzrE-1vgmA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 7 TYR A 310
ASP A 314
GLY A 256
PHE A 257
None
GOL  A 401 ( 4.5A)
None
None
0.78A 5nooA-1vgmA:
undetectable
5nooA-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 7 TYR A 310
ASP A 314
GLY A 256
PHE A 257
None
GOL  A 401 ( 4.5A)
None
None
0.79A 5nooB-1vgmA:
undetectable
5nooB-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 6 TYR A 310
ASP A 314
GLY A 256
PHE A 257
None
GOL  A 401 ( 4.5A)
None
None
0.81A 5nooC-1vgmA:
undetectable
5nooC-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 8 TYR A 310
ASP A 314
GLY A 256
PHE A 257
None
GOL  A 401 ( 4.5A)
None
None
0.81A 5nooD-1vgmA:
undetectable
5nooD-1vgmA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 11 MET A 174
ASP A 175
ILE A 179
LEU A 337
ILE A  70
None
1.22A 6fgdA-1vgmA:
0.0
6fgdA-1vgmA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 9 ILE A 131
ILE A 135
GLU A  75
VAL A  80
ILE A  84
None
1.27A 6hloA-1vgmA:
undetectable
6hloA-1vgmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
4 / 5 HIS A 184
ARG A 268
PHE A 335
ARG A 339
None
None
GOL  A 401 (-3.6A)
None
0.51A 6hxiB-1vgmA:
14.8
6hxiB-1vgmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii)
5 / 5 HIS A 184
ARG A 268
ASP A 314
PHE A 335
ARG A 339
None
None
GOL  A 401 ( 4.5A)
GOL  A 401 (-3.6A)
None
0.67A 6hxiD-1vgmA:
16.3
6hxiD-1vgmA:
22.34