SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A 129
ILE A 118
PHE A 326
LEU A 120
LEU A  95
 None
 1.40A 1eiiA-1vgpA:
0.0		 1eiiA-1vgpA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		3 / 3 ASN A 152
TYR A  73
SER A 122
 None
 0.93A 2gvcE-1vgpA:
0.0		 2gvcE-1vgpA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		3 / 3 HIS A 149
ILE A 178
LEU A  51
 None
 0.76A 2kceA-1vgpA:
undetectable		 2kceA-1vgpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 12 PHE A 322
SER A 333
HIS A 149
ILE A  94
LEU A 174
 None
 1.35A 2xkwA-1vgpA:
0.0		 2xkwA-1vgpA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 12 ASP A 106
GLY A 117
ILE A 118
PRO A 125
THR A 126
 None
 0.83A 3el4A-1vgpA:
undetectable		 3el4A-1vgpA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		4 / 4 LEU A  68
MET A 170
ILE A 203
ASP A 179
 None
 1.13A 3hecA-1vgpA:
0.0		 3hecA-1vgpA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 11 LEU A 274
LEU A 157
PHE A 322
PRO A 162
ALA A 169
 None
 1.31A 4hwkB-1vgpA:
0.0		 4hwkB-1vgpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 274
LEU A 157
PHE A 322
PRO A 162
ALA A 169
 None
 1.32A 4hwkC-1vgpA:
undetectable		 4hwkC-1vgpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 11 LEU A 274
LEU A 157
PHE A 322
PRO A 162
ALA A 169
 None
 1.33A 4hwkD-1vgpA:
undetectable		 4hwkD-1vgpA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		4 / 7 TYR A 306
ASP A 310
GLY A 251
PHE A 252
 None
 0.88A 4iqqA-1vgpA:
undetectable		 4iqqA-1vgpA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		4 / 8 TYR A 306
ASP A 310
GLY A 251
PHE A 252
 None
 0.89A 4iqqD-1vgpA:
undetectable		 4iqqD-1vgpA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  27
GLY A 216
GLY A 217
ASN A 219
GLY A 251
 None
 0.93A 4n09B-1vgpA:
undetectable		 4n09B-1vgpA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  27
GLY A 216
GLY A 217
ASN A 219
GLY A 251
 None
 0.91A 4n09C-1vgpA:
undetectable		 4n09C-1vgpA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  27
GLY A 216
GLY A 217
ASN A 219
GLY A 251
 None
 0.91A 4n09D-1vgpA:
undetectable		 4n09D-1vgpA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 11 ASP A 106
GLY A 117
ILE A 118
PRO A 125
THR A 126
 None
 0.88A 4njvB-1vgpA:
undetectable		 4njvB-1vgpA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		4 / 6 ARG A 248
GLN A 247
LEU A 300
PHE A 252
 None
 1.17A 5b1bC-1vgpA:
2.4
5b1bJ-1vgpA:
undetectable		 5b1bC-1vgpA:
19.90
5b1bJ-1vgpA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		3 / 3 SER A 314
LEU A 154
MET A 170
 None
 0.88A 5ikrB-1vgpA:
undetectable		 5ikrB-1vgpA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		4 / 6 TYR A 306
ASP A 310
GLY A 251
PHE A 252
 None
 0.92A 5nooC-1vgpA:
undetectable		 5nooC-1vgpA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		4 / 8 TYR A 306
ASP A 310
GLY A 251
PHE A 252
 None
 0.91A 5nooD-1vgpA:
undetectable		 5nooD-1vgpA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		4 / 4 ARG A 263
ILE A  34
TYR A  29
ILE A 178
 None
 1.44A 5odhG-1vgpA:
0.0		 5odhG-1vgpA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 267
VAL A 337
ARG A 263
ILE A 178
ASP A 179
 None
 1.24A 6bxnA-1vgpA:
undetectable		 6bxnA-1vgpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 267
VAL A 337
ARG A 263
ILE A 178
ASP A 179
 None
 1.21A 6bxnB-1vgpA:
undetectable		 6bxnB-1vgpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		4 / 5 HIS A 180
ARG A 263
PHE A 331
ARG A 335
 None
 0.56A 6hxiB-1vgpA:
13.2		 6hxiB-1vgpA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE
(Sulfurisphaera
tokodaii) 		5 / 5 HIS A 180
ARG A 263
ASP A 310
PHE A 331
ARG A 335
 None
 0.79A 6hxiD-1vgpA:
14.7		 6hxiD-1vgpA:
22.17