SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		5 / 12 GLU A 411
ILE A  70
ILE A  36
MET A  86
ARG A  68
 None
 1.48A 1ki3A-1vgqA:
0.0		 1ki3A-1vgqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		5 / 12 GLU A 411
ILE A  70
ILE A  36
MET A  86
ALA A  90
 None
 1.13A 1ki7B-1vgqA:
undetectable		 1ki7B-1vgqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 6 ARG A 192
ILE A 112
TRP A 109
GLU A 110
 None
 1.21A 1nsiC-1vgqA:
undetectable
1nsiD-1vgqA:
undetectable		 1nsiC-1vgqA:
22.01
1nsiD-1vgqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 5 GLU A 311
ARG A 217
LYS A 211
ASP A 214
 None
 1.45A 1rrjA-1vgqA:
0.0		 1rrjA-1vgqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 6 LEU A 207
ALA A 203
LEU A 167
VAL A 198
 None
 1.00A 1sn5A-1vgqA:
undetectable		 1sn5A-1vgqA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 8 THR A 152
LEU A 205
VAL A 208
VAL A 251
 None
 0.67A 1t86A-1vgqA:
undetectable		 1t86A-1vgqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 7 VAL A  55
ARG A 376
LEU A  58
HIS A 379
 None
 1.02A 2f78B-1vgqA:
undetectable		 2f78B-1vgqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 6 VAL A  55
ARG A 376
LEU A  58
HIS A 379
 None
 1.17A 2f8dA-1vgqA:
undetectable		 2f8dA-1vgqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 6 THR A 405
ARG A  46
LEU A  72
ASP A  43
 None
 1.06A 2wm3A-1vgqA:
6.7		 2wm3A-1vgqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 8 THR A  45
TYR A  59
ARG A 376
ASP A  43
 None
 1.07A 2xytE-1vgqA:
undetectable		 2xytE-1vgqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 8 THR A  45
TYR A  59
ARG A 376
ASP A  43
 None
 1.04A 2xytH-1vgqA:
undetectable		 2xytH-1vgqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		3 / 3 ARG A  38
VAL A 427
THR A  76
 CAO  A 429 (-3.1A)
None
None
 0.80A 3pwrA-1vgqA:
undetectable		 3pwrA-1vgqA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 7 ARG A 313
LEU A 317
ALA A 257
GLY A 260
 None
 0.70A 3spkB-1vgqA:
undetectable		 3spkB-1vgqA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		3 / 3 LYS A   3
PRO A   4
LEU A   5
 None
 0.81A 3tpxE-1vgqA:
undetectable		 3tpxE-1vgqA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		5 / 12 ASN A 256
PRO A 346
GLY A 348
GLU A 338
MET A 295
 None
 1.23A 3v3oB-1vgqA:
5.1		 3v3oB-1vgqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		5 / 12 PHE A 282
GLY A 264
PRO A 346
ALA A 341
MET A 295
 None
 1.24A 3v3oB-1vgqA:
5.1		 3v3oB-1vgqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		3 / 3 HIS A 404
GLU A 411
ASN A  32
 None
 0.95A 4bupB-1vgqA:
undetectable		 4bupB-1vgqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 7 TRP A 109
GLU A 110
ARG A 192
ILE A 112
 None
 1.29A 4nosA-1vgqA:
undetectable
4nosB-1vgqA:
undetectable		 4nosA-1vgqA:
21.63
4nosB-1vgqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 7 ARG A 192
ILE A 112
TRP A 109
GLU A 110
 None
 1.30A 4nosC-1vgqA:
undetectable
4nosD-1vgqA:
undetectable		 4nosC-1vgqA:
21.63
4nosD-1vgqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 6 TRP A 109
GLU A 110
ARG A 192
ILE A 112
 None
 1.26A 4nosC-1vgqA:
undetectable
4nosD-1vgqA:
undetectable		 4nosC-1vgqA:
21.63
4nosD-1vgqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 7 LEU A  83
MET A  74
MET A  86
ALA A  90
 None
CAO  A 429 (-4.5A)
None
None
 1.01A 4rjdB-1vgqA:
undetectable		 4rjdB-1vgqA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		3 / 3 ASP A  12
ARG A 376
ARG A  46
 None
 0.98A 4x5iA-1vgqA:
0.0		 4x5iA-1vgqA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		4 / 8 ILE A  87
LEU A  83
MET A  74
LEU A  72
 None
None
CAO  A 429 (-4.5A)
None
 1.06A 5u4sB-1vgqA:
6.2		 5u4sB-1vgqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		5 / 12 ILE A  70
PHE A  97
GLY A  79
THR A  76
MET A 105
 None
CAO  A 429 (-3.8A)
None
None
CAO  A 429 (-3.7A)
 1.11A 5v5zA-1vgqA:
0.0		 5v5zA-1vgqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		5 / 12 MET A 288
ALA A 286
ILE A 320
TYR A 281
ASP A 315
 None
 1.47A 5vlmA-1vgqA:
undetectable		 5vlmA-1vgqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		3 / 3 HIS A 404
GLU A 411
ASN A  32
 None
 0.95A 5wbvA-1vgqA:
undetectable		 5wbvA-1vgqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		3 / 3 HIS A 404
GLU A 411
ASN A  32
 None
 0.95A 5wbvB-1vgqA:
undetectable		 5wbvB-1vgqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		5 / 12 GLY A  42
VAL A  16
GLY A 402
SER A  69
ALA A 398
 None
CAO  A 429 (-4.1A)
None
None
None
 1.11A 6c2mB-1vgqA:
undetectable		 6c2mB-1vgqA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1vgq FORMYL-COENZYME A
TRANSFERASE
(Oxalobacter
formigenes) 		5 / 12 GLY A  42
VAL A  16
ILE A 375
SER A  69
ALA A 398
 None
CAO  A 429 (-4.1A)
None
None
None
 1.04A 6c2mB-1vgqA:
undetectable		 6c2mB-1vgqA:
14.13