SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 173
ALA A 172
ASP A 103
ILE A   6
ILE A 105
 None
 0.86A 1hshA-1vgwA:
undetectable		 1hshA-1vgwA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		3 / 3 ARG A  82
VAL A 194
GLY A 173
 None
 0.62A 2avvE-1vgwA:
undetectable		 2avvE-1vgwA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 173
ALA A 172
ASP A 103
ILE A   6
ILE A 105
 None
 0.85A 2hs1A-1vgwA:
undetectable		 2hs1A-1vgwA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 10 VAL A  54
GLY A  78
VAL A 107
ASN A  88
GLY A  89
 None
 1.16A 3km6A-1vgwA:
undetectable		 3km6A-1vgwA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 9 VAL A  54
GLY A  78
VAL A 107
ASN A  88
GLY A  89
 None
 1.18A 3kmoA-1vgwA:
undetectable		 3kmoA-1vgwA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 9 GLY A 173
ALA A 172
ASP A 103
ILE A   6
ILE A 105
 None
 0.82A 3nu4B-1vgwA:
undetectable		 3nu4B-1vgwA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		3 / 3 ALA A 141
VAL A 140
GLN A 163
 None
 0.71A 3of4B-1vgwA:
0.0		 3of4B-1vgwA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 11 GLY A 173
ALA A 172
ASP A 103
ILE A   6
ILE A 105
 None
 0.85A 3s45B-1vgwA:
undetectable		 3s45B-1vgwA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		3 / 3 ASN A 104
LEU A  94
PHE A 170
 None
 0.79A 4dajB-1vgwA:
undetectable		 4dajB-1vgwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 8 ILE A 124
PRO A 167
PHE A  42
LEU A 115
 None
 0.84A 4qopC-1vgwA:
undetectable		 4qopC-1vgwA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  93
LEU A   8
HIS A 176
LEU A 175
ILE A 105
 None
 0.91A 4x1fA-1vgwA:
undetectable		 4x1fA-1vgwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  93
LEU A   8
HIS A 176
LEU A 175
ILE A 105
 None
 0.95A 4x1gA-1vgwA:
undetectable		 4x1gA-1vgwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 8 LEU A  93
GLY A  89
VAL A  90
ALA A 172
GLY A  97
 None
 1.28A 4zauA-1vgwA:
undetectable		 4zauA-1vgwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 173
ALA A 172
ASP A 103
ILE A   6
ILE A 105
 None
 0.82A 5e5kA-1vgwA:
undetectable		 5e5kA-1vgwA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 124
GLY A 128
HIS A  45
PHE A  42
ALA A   7
 None
 1.24A 5igyA-1vgwA:
undetectable		 5igyA-1vgwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		3 / 3 GLY A  89
THR A  85
ASN A  77
 None
 0.66A 5odiG-1vgwA:
3.3		 5odiG-1vgwA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		3 / 3 VAL A  74
VAL A  53
GLN A  25
 None
 0.71A 5qglA-1vgwA:
undetectable		 5qglA-1vgwA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 173
ALA A 172
ASP A 103
ILE A   6
ILE A 105
 None
 0.82A 5t8hA-1vgwA:
undetectable		 5t8hA-1vgwA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE
(Neisseria
gonorrhoeae) 		4 / 7 ARG A 112
ALA A 208
ILE A 221
LEU A 225
 None
 0.83A 5te8C-1vgwA:
undetectable		 5te8C-1vgwA:
17.96