SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A 104
ALA A  37
GLN A 227
ASN A 115
LEU A 126
 None
 1.27A 1u70A-1vh1A:
undetectable		 1u70A-1vh1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 9 LEU A 212
LEU A 215
ILE A 221
PHE A 155
TYR A 185
 None
 1.16A 2f78A-1vh1A:
undetectable		 2f78A-1vh1A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 ASP A 100
ILE A 104
VAL A   5
THR A  76
 None
 1.22A 3eigA-1vh1A:
1.6		 3eigA-1vh1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A 166
PRO A 161
PHE A 167
 None
 1.02A 3thrC-1vh1A:
undetectable		 3thrC-1vh1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 8 PRO A 230
LEU A 182
VAL A 223
VAL A 112
 None
 1.03A 4pwdA-1vh1A:
undetectable		 4pwdA-1vh1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Escherichia
coli) 		4 / 5 ALA A 124
THR A 125
TYR A 185
HIS A 222
 None
 1.30A 5ecmA-1vh1A:
undetectable		 5ecmA-1vh1A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 8 VAL A  58
ILE A  30
ALA A   9
THR A  49
VAL A  65
 None
 1.43A 5l94A-1vh1A:
undetectable		 5l94A-1vh1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1vh1 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE
(Escherichia
coli) 		5 / 8 VAL A 112
ILE A 108
ALA A 106
VAL A   5
VAL A  95
 None
 1.50A 5l94A-1vh1A:
undetectable		 5l94A-1vh1A:
21.99