SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		4 / 4 ILE A 123
LEU A 156
VAL A 132
ILE A 129
 None
 0.73A 1fm6D-1vhcA:
0.0		 1fm6D-1vhcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 11 ILE A   9
LYS A  11
LEU A  12
THR A 112
PHE A  90
 None
 1.38A 1tw4A-1vhcA:
undetectable		 1tw4A-1vhcA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		4 / 6 LEU A  59
ALA A  62
SER A  86
SER A  85
 None
 1.02A 1tz8C-1vhcA:
undetectable
1tz8D-1vhcA:
undetectable		 1tz8C-1vhcA:
22.62
1tz8D-1vhcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		4 / 8 LEU A  36
ILE A  21
ILE A 200
ILE A 192
 None
 0.82A 2bu8A-1vhcA:
undetectable		 2bu8A-1vhcA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.94A 2ieoA-1vhcA:
undetectable		 2ieoA-1vhcA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.89A 2q63A-1vhcA:
undetectable		 2q63A-1vhcA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.84A 2qakA-1vhcA:
undetectable		 2qakA-1vhcA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		4 / 8 PHE A  90
VAL A  18
ASP A  89
ILE A   8
 None
 0.82A 2qbmA-1vhcA:
undetectable		 2qbmA-1vhcA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.84A 3bvbB-1vhcA:
undetectable		 3bvbB-1vhcA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		4 / 6 GLY A 165
TYR A 172
GLY A 183
ASN A 168
 None
 1.10A 3e9rC-1vhcA:
undetectable		 3e9rC-1vhcA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 9 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.90A 3ektA-1vhcA:
undetectable		 3ektA-1vhcA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 9 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.91A 3gguB-1vhcA:
undetectable		 3gguB-1vhcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		4 / 8 ILE A  21
ARG A  64
PHE A  67
ALA A  37
 None
 0.93A 3hrdA-1vhcA:
undetectable
3hrdB-1vhcA:
undetectable		 3hrdA-1vhcA:
18.96
3hrdB-1vhcA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.86A 3k4vA-1vhcA:
undetectable		 3k4vA-1vhcA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.84A 3ndtA-1vhcA:
undetectable		 3ndtA-1vhcA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.85A 3s54B-1vhcA:
undetectable		 3s54B-1vhcA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 9 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.92A 4dqcB-1vhcA:
undetectable		 4dqcB-1vhcA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 11 THR A 112
CYH A 104
ALA A  71
GLY A  72
THR A  73
 None
 0.94A 4qvvH-1vhcA:
undetectable		 4qvvH-1vhcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 11 THR A 112
CYH A 104
ALA A  71
GLY A  72
THR A  73
 None
 0.94A 4qvvV-1vhcA:
undetectable		 4qvvV-1vhcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 11 THR A 112
CYH A 104
ALA A  71
GLY A  72
THR A  73
 None
 0.95A 4qvyH-1vhcA:
undetectable		 4qvyH-1vhcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		4 / 6 ASN A  39
ASP A 198
PRO A  19
VAL A 204
 None
 1.02A 4yoaA-1vhcA:
undetectable		 4yoaA-1vhcA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 11 THR A 112
CYH A 104
ALA A  71
GLY A  72
THR A  73
 None
 0.95A 5d0xV-1vhcA:
undetectable		 5d0xV-1vhcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 1vhc PUTATIVE KHG/KDPG
ALDOLASE
(Haemophilus
influenzae) 		5 / 12 LEU A  82
GLY A  87
ALA A  88
ASP A  89
ILE A  29
 None
 0.83A 5e5kA-1vhcA:
undetectable		 5e5kA-1vhcA:
18.10