SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ALA A 283
ALA A 286
ILE A 358
HIS A 272
LEU A 315
 None
 0.94A 1fm6U-1vheA:
undetectable		 1fm6U-1vheA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ILE A 324
ILE A 240
GLU A 214
ALA A  66
THR A 318
 None
None
ZN  A 372 ( 3.9A)
None
None
 1.27A 1jtxA-1vheA:
undetectable		 1jtxA-1vheA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLN A 229
ALA A 309
VAL A 312
GLY A 311
ILE A 347
 None
 1.17A 1kxhA-1vheA:
undetectable		 1kxhA-1vheA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1870_0
(FPRA)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 4 HIS A 202
PRO A 203
LYS A 348
ILE A 347
 None
 1.28A 1lqtA-1vheA:
3.0		 1lqtA-1vheA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 9 GLY A  92
PRO A 163
GLU A  71
GLY A  73
ASP A 182
 None
None
None
None
ZN  A 372 (-2.5A)
 0.98A 1mxdA-1vheA:
undetectable		 1mxdA-1vheA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 11 GLY A  92
PRO A 163
GLU A  71
GLY A  73
ASP A 182
 None
None
None
None
ZN  A 372 (-2.5A)
 0.97A 1mxgA-1vheA:
undetectable		 1mxgA-1vheA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 4 HIS A  68
ASP A 266
SER A 271
ASP A 237
 ZN  A 372 (-3.5A)
None
None
ZN  A 372 (-1.9A)
 1.43A 1n2xA-1vheA:
0.2		 1n2xA-1vheA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ILE A 240
GLY A 299
ALA A 304
SER A 302
HIS A  68
 None
None
None
None
ZN  A 372 (-3.5A)
 1.18A 1nbhA-1vheA:
undetectable		 1nbhA-1vheA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ILE A 240
GLY A 299
ALA A 304
SER A 302
HIS A  68
 None
None
None
None
ZN  A 372 (-3.5A)
 1.18A 1nbhC-1vheA:
undetectable		 1nbhC-1vheA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ILE A 240
GLY A 299
ALA A 304
SER A 302
HIS A  68
 None
None
None
None
ZN  A 372 (-3.5A)
 1.18A 1nbhD-1vheA:
undetectable		 1nbhD-1vheA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 VAL A 346
ILE A 347
ILE A  63
VAL A 279
LEU A 275
 None
 0.87A 1qhsA-1vheA:
2.3		 1qhsA-1vheA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 VAL A 346
ILE A 347
ILE A  63
VAL A 279
LEU A 275
 None
 0.95A 1qhyA-1vheA:
2.3		 1qhyA-1vheA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 6 ALA A 241
SER A 254
ILE A 295
ASP A 293
 None
 0.98A 1yc2A-1vheA:
undetectable		 1yc2A-1vheA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		6 / 12 GLY A 235
LEU A  69
GLY A 210
ILE A  35
ASN A 183
LEU A  14
 None
None
None
None
ZN  A 372 ( 4.7A)
None
 1.27A 2nxeA-1vheA:
undetectable		 2nxeA-1vheA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 297
GLY A 239
GLY A 299
THR A 318
ASP A 335
 None
 0.89A 2pxcA-1vheA:
undetectable		 2pxcA-1vheA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ASP A 266
ASP A 182
ILE A 324
ALA A  66
HIS A  68
 None
ZN  A 372 (-2.5A)
None
None
ZN  A 372 (-3.5A)
 1.36A 2qmjA-1vheA:
undetectable		 2qmjA-1vheA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 5 PRO A 245
ILE A 247
ARG A 322
ASP A 243
 None
 1.44A 2rhmB-1vheA:
3.2		 2rhmB-1vheA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 235
ILE A 347
VAL A 206
GLY A 208
ILE A 343
 None
 0.86A 2rkgA-1vheA:
undetectable		 2rkgA-1vheA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 186
ILE A 319
ASP A 182
THR A 211
GLU A 214
 None
None
ZN  A 372 (-2.5A)
None
ZN  A 372 ( 3.9A)
 1.25A 2vdvE-1vheA:
undetectable		 2vdvE-1vheA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 11 GLY A 186
ILE A 319
ASP A 182
THR A 211
GLU A 214
 None
None
ZN  A 372 (-2.5A)
None
ZN  A 372 ( 3.9A)
 1.26A 2vdvF-1vheA:
undetectable		 2vdvF-1vheA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 8 GLN A 261
TYR A 323
ARG A 322
THR A 326
 None
 1.45A 2vxaF-1vheA:
undetectable
2vxaG-1vheA:
undetectable
2vxaI-1vheA:
undetectable		 2vxaF-1vheA:
12.77
2vxaG-1vheA:
12.77
2vxaI-1vheA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ALA A 144
VAL A  76
ASP A 159
GLY A 143
ILE A 142
 None
 1.48A 3a65A-1vheA:
0.0		 3a65A-1vheA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 9 LEU A 350
ILE A 305
GLY A 235
ILE A 317
ILE A 232
 None
 1.18A 3d1yB-1vheA:
undetectable		 3d1yB-1vheA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 9 ILE A 305
GLY A 235
ILE A 317
VAL A 206
ILE A  63
 None
 1.26A 3ekyB-1vheA:
undetectable		 3ekyB-1vheA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 8 GLY A  67
ALA A  66
ASP A 301
LEU A  50
VAL A 206
 None
 1.07A 3em6A-1vheA:
undetectable		 3em6A-1vheA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 10 GLY A 235
ILE A 347
VAL A 206
GLY A 208
ILE A 343
 None
 0.90A 3s43B-1vheA:
undetectable		 3s43B-1vheA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 8 VAL A 206
LEU A 194
LEU A 197
ILE A 343
 None
 0.84A 3u5kD-1vheA:
undetectable		 3u5kD-1vheA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 5 ARG A 276
LEU A 315
PRO A 313
ASP A 277
 None
 0.96A 3ufnA-1vheA:
undetectable
3ufnB-1vheA:
undetectable		 3ufnA-1vheA:
15.14
3ufnB-1vheA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ASP A 182
ASP A  45
CYH A 187
ASP A  70
GLU A 215
 ZN  A 372 (-2.5A)
None
None
None
ZN  A 372 ( 4.5A)
 1.42A 4feuA-1vheA:
undetectable
4feuB-1vheA:
0.0		 4feuA-1vheA:
22.25
4feuB-1vheA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 10 ASP A 182
ASP A  45
CYH A 187
ASP A  70
GLU A 215
 ZN  A 372 (-2.5A)
None
None
None
ZN  A 372 ( 4.5A)
 1.44A 4feuC-1vheA:
0.0		 4feuC-1vheA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 7 ASP A 182
GLU A 215
HIS A 325
GLU A 214
 ZN  A 372 (-2.5A)
ZN  A 372 ( 4.5A)
None
ZN  A 372 ( 3.9A)
 1.01A 4hvrA-1vheA:
undetectable		 4hvrA-1vheA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		8 / 11 HIS A  68
ASP A 182
GLU A 214
GLU A 215
GLY A 297
GLY A 298
ILE A 324
HIS A 325
 ZN  A 372 (-3.5A)
ZN  A 372 (-2.5A)
ZN  A 372 ( 3.9A)
ZN  A 372 ( 4.5A)
None
None
None
None
 0.92A 4pqaA-1vheA:
22.8		 4pqaA-1vheA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 7 ILE A 343
PHE A 234
VAL A 236
ILE A 185
 None
 0.72A 5bmvC-1vheA:
3.7		 5bmvC-1vheA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ALA A  52
PHE A 234
GLY A 235
GLY A 210
LEU A  50
 None
 1.03A 5i71A-1vheA:
0.4		 5i71A-1vheA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 297
GLY A 239
GLY A 299
THR A 318
ASP A 335
 None
 0.86A 5ikmA-1vheA:
undetectable		 5ikmA-1vheA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 9 LEU A 350
ILE A 305
GLY A 235
ILE A 317
ILE A 232
 None
 1.10A 5kr2D-1vheA:
undetectable		 5kr2D-1vheA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 235
ILE A 347
VAL A 206
GLY A 208
ILE A 343
 None
 0.86A 5t8hA-1vheA:
undetectable		 5t8hA-1vheA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 297
GLY A 239
GLY A 299
THR A 318
ASP A 335
 None
 0.93A 5wz1A-1vheA:
undetectable		 5wz1A-1vheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 297
GLY A 239
GLY A 299
THR A 318
ASP A 335
 None
 0.95A 5wz1C-1vheA:
undetectable		 5wz1C-1vheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 297
GLY A 239
GLY A 299
THR A 318
ASP A 335
 None
 0.94A 5wz1D-1vheA:
undetectable		 5wz1D-1vheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 297
GLY A 239
GLY A 299
THR A 318
ASP A 335
 None
 0.96A 5wz1E-1vheA:
undetectable		 5wz1E-1vheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 297
GLY A 239
GLY A 299
THR A 318
ASP A 335
 None
 0.96A 5wz1F-1vheA:
undetectable		 5wz1F-1vheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 297
GLY A 239
GLY A 299
THR A 318
ASP A 335
 None
 0.95A 5wz1G-1vheA:
undetectable		 5wz1G-1vheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 GLY A 297
GLY A 239
GLY A 299
THR A 318
ASP A 335
 None
 0.94A 5wz1H-1vheA:
undetectable		 5wz1H-1vheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 11 GLY A 186
ALA A 188
ALA A 190
ILE A  65
VAL A 236
 None
 1.21A 5yk2A-1vheA:
undetectable		 5yk2A-1vheA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ALA A 283
ALA A 286
ILE A 358
HIS A 272
LEU A 315
 None
 0.89A 6a5zL-1vheA:
undetectable		 6a5zL-1vheA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		5 / 12 ALA A 283
ALA A 286
ILE A 358
HIS A 272
LEU A 315
 None
 0.96A 6a60D-1vheA:
undetectable		 6a60D-1vheA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		3 / 3 LEU A 176
LEU A   8
ARG A 333
 None
 0.68A 6fgdA-1vheA:
3.7		 6fgdA-1vheA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 6 ASP A  45
GLU A  24
ASP A  70
GLU A 214
 None
None
None
ZN  A 372 ( 3.9A)
 1.12A 6mn5A-1vheA:
0.0		 6mn5A-1vheA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG
(Bacillus
subtilis) 		4 / 6 ASP A  45
GLU A  24
ASP A  70
GLU A 214
 None
None
None
ZN  A 372 ( 3.9A)
 1.24A 6mn5C-1vheA:
undetectable		 6mn5C-1vheA:
16.44