SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vhh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		5 / 12 LEU A 107
ASN A 108
LEU A 110
ALA A 111
MET A  99
 None
 1.14A 1ya3C-1vhhA:
undetectable		 1ya3C-1vhhA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		5 / 12 LEU A 107
ASN A 108
LEU A 110
ALA A 111
MET A  99
 None
 1.16A 2aa6A-1vhhA:
undetectable		 2aa6A-1vhhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		3 / 3 ASP A  96
ASP A 130
ASN A  92
 None
 0.67A 2bm9D-1vhhA:
undetectable		 2bm9D-1vhhA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		3 / 3 GLU A  54
LEU A 140
LEU A 107
 None
 0.67A 3ohtA-1vhhA:
undetectable		 3ohtA-1vhhA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		3 / 3 GLU A  54
LEU A 140
LEU A 107
 None
 0.64A 3ohtB-1vhhA:
undetectable		 3ohtB-1vhhA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		3 / 3 HIS A 141
SER A  60
GLU A  54
 ZN  A 400 ( 3.2A)
None
None
 0.67A 3s8pA-1vhhA:
undetectable		 3s8pA-1vhhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		4 / 5 THR A  68
ILE A  67
LYS A  66
GLU A 143
 None
 1.46A 4ac9C-1vhhA:
undetectable		 4ac9C-1vhhA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		4 / 5 THR A  68
ILE A  67
LYS A  66
GLU A 143
 None
 1.45A 4acaC-1vhhA:
undetectable		 4acaC-1vhhA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		4 / 5 THR A  68
ILE A  67
LYS A  66
GLU A 143
 None
 1.50A 4acbC-1vhhA:
undetectable		 4acbC-1vhhA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		5 / 12 LEU A 107
ASN A 108
LEU A 110
ALA A 111
MET A  99
 None
 1.11A 4fn9B-1vhhA:
undetectable		 4fn9B-1vhhA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		4 / 7 ASP A  96
THR A 126
ARG A 124
PHE A  87
 None
SO4  A 401 (-3.7A)
SO4  A 401 (-2.7A)
None
 1.45A 4o4dA-1vhhA:
undetectable		 4o4dA-1vhhA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		3 / 3 ASP A 148
GLY A 128
ASP A  96
 ZN  A 400 ( 2.1A)
None
None
 0.60A 4xdtA-1vhhA:
undetectable		 4xdtA-1vhhA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1vhh SONIC HEDGEHOG
(Mus
musculus) 		5 / 6 SER A  71
GLU A  72
GLY A 128
ASP A 130
GLY A 144
 None
 1.46A 5cdnA-1vhhA:
undetectable
5cdnB-1vhhA:
undetectable		 5cdnA-1vhhA:
16.74
5cdnB-1vhhA:
21.74