SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1vhn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 202
ALA A 201
PHE A 229
LEU A 230
ILE A 226
 None
 0.95A 1g5yB-1vhnA:
undetectable		 1g5yB-1vhnA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 LEU A  23
VAL A 294
LEU A 297
LEU A 254
LEU A 253
 None
 1.06A 1mx1A-1vhnA:
2.7		 1mx1A-1vhnA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 PRO A  70
GLY A  67
VAL A  37
SER A  38
ALA A  76
 SO4  A 320 (-4.1A)
None
None
None
None
 1.13A 1sg9C-1vhnA:
2.0		 1sg9C-1vhnA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		3 / 3 VAL A 188
VAL A 212
TRP A 174
 None
 0.88A 1w5uA-1vhnA:
undetectable
1w5uB-1vhnA:
undetectable		 1w5uA-1vhnA:
3.00
1w5uB-1vhnA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 ASN A 140
THR A 133
ILE A 159
LEU A 177
THR A 186
 None
 0.98A 3bexC-1vhnA:
undetectable
3bexD-1vhnA:
undetectable		 3bexC-1vhnA:
23.46
3bexD-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 10 LEU A 177
THR A 186
ASN A 140
THR A 133
ILE A 159
 None
 0.98A 3bexC-1vhnA:
undetectable
3bexD-1vhnA:
undetectable		 3bexC-1vhnA:
23.46
3bexD-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 10 ASN A 140
THR A 133
ILE A 159
LEU A 177
THR A 186
 None
 1.00A 3bexE-1vhnA:
undetectable
3bexF-1vhnA:
undetectable		 3bexE-1vhnA:
23.46
3bexF-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 LEU A 177
THR A 186
ASN A 140
THR A 133
ILE A 159
 None
 0.98A 3bexE-1vhnA:
undetectable
3bexF-1vhnA:
undetectable		 3bexE-1vhnA:
23.46
3bexF-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 ASN A 140
THR A 133
ILE A 159
LEU A 177
THR A 186
 None
 1.03A 3bf1A-1vhnA:
undetectable
3bf1B-1vhnA:
undetectable		 3bf1A-1vhnA:
23.46
3bf1B-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 177
THR A 186
ASN A 140
THR A 133
ILE A 159
 None
 1.01A 3bf1A-1vhnA:
undetectable
3bf1B-1vhnA:
undetectable		 3bf1A-1vhnA:
23.46
3bf1B-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 ASN A 140
THR A 133
ILE A 159
LEU A 177
THR A 186
 None
 1.00A 3bf1C-1vhnA:
undetectable
3bf1D-1vhnA:
undetectable		 3bf1C-1vhnA:
23.46
3bf1D-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 LEU A 177
THR A 186
ASN A 140
THR A 133
ILE A 159
 None
 0.97A 3bf1C-1vhnA:
undetectable
3bf1D-1vhnA:
undetectable		 3bf1C-1vhnA:
23.46
3bf1D-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 ASN A 140
THR A 133
ILE A 159
LEU A 177
THR A 186
 None
 1.01A 3bf1E-1vhnA:
undetectable
3bf1F-1vhnA:
undetectable		 3bf1E-1vhnA:
23.46
3bf1F-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 11 LEU A 177
THR A 186
ASN A 140
THR A 133
ILE A 159
 None
 0.98A 3bf1E-1vhnA:
undetectable
3bf1F-1vhnA:
undetectable		 3bf1E-1vhnA:
23.46
3bf1F-1vhnA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  73
ALA A  62
GLY A  92
ALA A  91
LEU A 107
 None
None
SO4  A 319 (-3.6A)
None
None
 1.09A 3ln1D-1vhnA:
undetectable		 3ln1D-1vhnA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 10 ALA A 106
LEU A  89
ILE A 117
VAL A 154
VAL A 157
 None
 1.31A 3r9cA-1vhnA:
undetectable		 3r9cA-1vhnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 8 ALA A  24
PHE A 223
PHE A  31
ALA A  32
 None
 0.89A 3t3sD-1vhnA:
undetectable		 3t3sD-1vhnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 7 PHE A  33
GLY A   8
THR A  16
PHE A  25
 None
 1.12A 3vnsA-1vhnA:
undetectable		 3vnsA-1vhnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 9 ILE A 145
GLY A 136
VAL A 131
THR A 133
GLY A  92
 None
None
None
None
SO4  A 319 (-3.6A)
 1.32A 4acaB-1vhnA:
2.6
4acaC-1vhnA:
2.2		 4acaB-1vhnA:
23.53
4acaC-1vhnA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 7 LEU A  23
ALA A  29
ASP A  30
ILE A 192
 None
None
None
FMN  A 322 (-4.7A)
 0.87A 4eyrA-1vhnA:
undetectable		 4eyrA-1vhnA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 ASN A 140
LEU A 149
ILE A 159
LEU A 177
THR A 186
 None
 1.12A 4o5fA-1vhnA:
undetectable
4o5fB-1vhnA:
undetectable		 4o5fA-1vhnA:
23.14
4o5fB-1vhnA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 ASN A 140
THR A 133
ILE A 159
LEU A 177
THR A 186
 None
 0.99A 4o5fA-1vhnA:
undetectable
4o5fB-1vhnA:
undetectable		 4o5fA-1vhnA:
23.14
4o5fB-1vhnA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 177
THR A 186
ASN A 140
LEU A 149
ILE A 159
 None
 1.11A 4o5fA-1vhnA:
undetectable
4o5fB-1vhnA:
undetectable		 4o5fA-1vhnA:
23.14
4o5fB-1vhnA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 177
THR A 186
ASN A 140
THR A 133
ILE A 159
 None
 0.98A 4o5fA-1vhnA:
undetectable
4o5fB-1vhnA:
undetectable		 4o5fA-1vhnA:
23.14
4o5fB-1vhnA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		4 / 5 GLU A 266
LYS A 258
ASP A  17
GLU A  35
 None
 1.02A 5a06A-1vhnA:
2.0		 5a06A-1vhnA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 ASN A 140
LEU A 149
ILE A 159
LEU A 177
THR A 186
 None
 1.09A 5b8hA-1vhnA:
1.0
5b8hB-1vhnA:
undetectable		 5b8hA-1vhnA:
22.82
5b8hB-1vhnA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 ASN A 140
THR A 133
ILE A 159
LEU A 177
THR A 186
 None
 0.97A 5b8hA-1vhnA:
1.0
5b8hB-1vhnA:
undetectable		 5b8hA-1vhnA:
22.82
5b8hB-1vhnA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 177
THR A 186
ASN A 140
LEU A 149
ILE A 159
 None
 1.13A 5b8hA-1vhnA:
undetectable
5b8hB-1vhnA:
undetectable		 5b8hA-1vhnA:
22.82
5b8hB-1vhnA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A 177
THR A 186
ASN A 140
THR A 133
ILE A 159
 None
 1.02A 5b8hA-1vhnA:
undetectable
5b8hB-1vhnA:
undetectable		 5b8hA-1vhnA:
22.82
5b8hB-1vhnA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 12 LEU A  73
ALA A  62
GLY A  92
ALA A  91
LEU A 107
 None
None
SO4  A 319 (-3.6A)
None
None
 1.10A 5jw1B-1vhnA:
0.0		 5jw1B-1vhnA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		3 / 3 VAL A 188
SER A 189
TRP A 174
 None
FMN  A 322 (-3.0A)
None
 1.05A 5jwaA-1vhnA:
undetectable		 5jwaA-1vhnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		5 / 9 LEU A 210
ILE A 192
GLY A 190
LEU A 202
ALA A 201
 None
FMN  A 322 (-4.7A)
FMN  A 322 (-3.5A)
None
None
 0.98A 5o96A-1vhnA:
undetectable
5o96B-1vhnA:
3.3		 5o96A-1vhnA:
20.13
5o96B-1vhnA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE
(Thermotoga
maritima) 		3 / 3 ARG A 162
PHE A 193
ARG A 214
 FMN  A 322 ( 4.8A)
None
FMN  A 322 (-3.7A)
 1.19A 5y9yA-1vhnA:
0.0		 5y9yA-1vhnA:
23.46